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Acyl-CoA dehydrogenase
From Proteopedia
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| - | + | *Short chain ACDH | |
| - | [[1jqi]] - SCAD + acetoacetyl-CoA + FAD – rat<BR /> | + | **[[1jqi]] - SCAD + acetoacetyl-CoA + FAD – rat<BR /> |
| - | [[2dvl]], [[2z1q]] - TtSCAD + FAD – ''Thermus thermophilus''<BR /> | + | **[[2dvl]], [[2z1q]] - TtSCAD + FAD – ''Thermus thermophilus''<BR /> |
| - | [[2jif]], [[2vig]] - hSCAD + CoA persulfide + FAD – human | + | **[[2jif]], [[2vig]] - hSCAD + CoA persulfide + FAD – human |
| - | + | *Medium chain ACDH | |
| - | [[1ws9]], [[2cx9]] - TtMCAD <BR /> | + | **[[1ws9]], [[2cx9]] - TtMCAD <BR /> |
| - | [[3mdd]] – pMCAD + FAD – pig<BR /> | + | **[[3mdd]] – pMCAD + FAD – pig<BR /> |
| - | [[1egd]], [[1ege]] - hMCAD (mutant) + FAD<BR /> | + | **[[1egd]], [[1ege]] - hMCAD (mutant) + FAD<BR /> |
| - | [[1ukw]], [[2d29]] - TtMCAD + FAD<BR /> | + | **[[1ukw]], [[2d29]] - TtMCAD + FAD<BR /> |
| - | [[1egc]] - hMCAD (mutant) + octanoyl-CoA + FAD<BR /> | + | **[[1egc]] - hMCAD (mutant) + octanoyl-CoA + FAD<BR /> |
| - | [[3mde]] - pMCAD + octanoyl-CoA + FAD<BR /> | + | **[[3mde]] - pMCAD + octanoyl-CoA + FAD<BR /> |
| - | [[1udy]] - pMCAD + thiaoctanoyl-CoA + FAD<BR /> | + | **[[1udy]] - pMCAD + thiaoctanoyl-CoA + FAD<BR /> |
| - | [[1t9g]] - hMCAD + electron transfer flavoprotein + AMP + FAD<BR /> | + | **[[1t9g]] - hMCAD + electron transfer flavoprotein + AMP + FAD<BR /> |
| - | [[2a1t]] - hMCAD + electron transfer flavoprotein (mutant) + AMP + FAD<BR /> | + | **[[2a1t]] - hMCAD + electron transfer flavoprotein (mutant) + AMP + FAD<BR /> |
| - | + | *Very long chain ACDH | |
| - | [[2uxw]] - hVLCAD + tetradecanoyl CoA + FAD<BR /> | + | **[[2uxw]] - hVLCAD + tetradecanoyl CoA + FAD<BR /> |
| - | [[3b96]] - hVLCAD + trans-δ2-palmitenoyl CoA + FAD<BR /> | + | **[[3b96]] - hVLCAD + trans-δ2-palmitenoyl CoA + FAD<BR /> |
| - | + | *Unspecified length ACDH | |
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| + | **[[2oku]] – ACDH C terminal – ''Porphyromonas gingivalis''<BR /> | ||
| + | **[[2pg0]] - ACDH + FAD – ''Geobacillus kaustophilus''<BR /> | ||
| + | **[[2wbi]] – hACDH 11 + FAD<BR /> | ||
| + | **[[3nf4]], [[3pfd]] – ACHD + FAD – ''Mycobacterium thermoresistibile''<BR /> | ||
| + | **[[3oib]] - ACHD + FAD – ''Mycobacterium smegmatis''<br /> | ||
| + | **[[4m9a]] – ACDH + FAD – ''Burkholderia thailandensis''<br /> | ||
| + | **[[3owa]] - ACDH + FAD – ''Bacillus anthracis'' | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:57, 12 November 2014
Acyl-CoA dehydrogenase (ACDH) catalyzes the introduction of a double bond between C2 and C3 of the thio-ester CoA substrate. This is the first reaction in fatty acid metabolism which produces acetyl-CoA. FAD is the cofactor of ACDH activity. ACDH is classified according to the length of its substrates as short- (SCAD), medium- (MCAD), very- and very long-chain (VLCAD) ACDH. Impairment of the activity of ACDH causes a variety of diseases associated with lack of fatty acid metabolism.
3D structures of acyl-CoA dehydrogenase
Updated on 12-November-2014
