Caspase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===CASP-1===
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*CASP-1
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[[3e4c]] – hpro-CASP (mutant) - human<br />
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**[[3e4c]] – hpro-CASP (mutant) - human<br />
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[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br />
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**[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br />
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[[1sc1]], [[1sc4]] - hCASP (mutant) <br />
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**[[1sc1]], [[1sc4]] - hCASP (mutant) <br />
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[[1sc3]] - hCASP (mutant) + malonate<br />
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**[[1sc3]] - hCASP (mutant) + malonate<br />
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[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br />
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**[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br />
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[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br />
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**[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br />
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[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br />
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**[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br />
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[[1ice]] – hCASP + tetrapeptide aldehyde<br />
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**[[1ice]] – hCASP + tetrapeptide aldehyde<br />
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[[1m72]] – SfCASP + polypeptide inhibitor<br />
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**[[1m72]] – SfCASP + polypeptide inhibitor<br />
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===CASP-2===
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*CASP-2
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[[2p2c]] – hCASP<br />
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**[[2p2c]] – hCASP<br />
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[[3r7s]] - hCASP subunits P12, P18<br />
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**[[3r7s]] - hCASP subunits P12, P18<br />
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[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br />
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**[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br />
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===CASP-3===
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*CASP-3
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[[1qx3]] - hCASP<br />
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**[[1qx3]] - hCASP<br />
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[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
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**[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
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[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
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**[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
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[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br />
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**[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br />
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[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]] – hCASP subunits P12, P17 + polypeptide inhibitor<br />
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**[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]] – hCASP subunits P12, P17 + polypeptide inhibitor<br />
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[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br />
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**[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br />
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[[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br />
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**[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br />
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[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br />
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**[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
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[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
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**[[1i3o]] - hCASP (mutant) + XIAP-BIR2
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[[1i3o]] - hCASP (mutant) + XIAP-BIR2
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===CASP-6===
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*CASP-6
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[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br />
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**[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br />
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[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]] – hCASP (mutant) <br />
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**[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]] – hCASP (mutant) <br />
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[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
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**[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
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[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
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**[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
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[[4fxo]] - hCASP subunit P11 + P18 + Zn<br />
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**[[4fxo]] - hCASP subunit P11 + P18 + Zn<br />
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[[4hva]] - hCASP subunit P11 + P18 + VEID inhibitor<br />
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**[[4hva]] - hCASP subunit P11 + P18 + VEID inhibitor<br />
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[[4n5d]] - hCASP subunit P11 + P18 + inhibitor<br />
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**[[4n5d]] - hCASP subunit P11 + P18 + inhibitor<br />
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[[4n6g]], [[4n7j]], [[4n7m]], [[4nbk]], [[4nbl]], [[4nbn]] - hCASP subunit P11 + P18 (mutant) + inhibitor<br />
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**[[4n6g]], [[4n7j]], [[4n7m]], [[4nbk]], [[4nbl]], [[4nbn]] - hCASP subunit P11 + P18 (mutant) + inhibitor<br />
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===CASP-7===
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*CASP-7
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[[3rk5]], [[4fdi]] - hCASP<br />
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**[[3rk5]], [[4fdi]] - hCASP<br />
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[[3ibf]] – hCASP P20 subunit<br />
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**[[3ibf]] – hCASP P20 subunit<br />
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[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
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**[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
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[[1k86]], [[1gqf]] – hCASP catalytic domain<br />
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**[[1k86]], [[1gqf]] – hCASP catalytic domain<br />
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[[1k88]] – hpro-CASP (mutant) <br />
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**[[1k88]] – hpro-CASP (mutant) <br />
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[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br />
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**[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br />
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[[1f1j]] - hCASP + polypeptide inhibitor<br />
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**[[1f1j]] - hCASP + polypeptide inhibitor<br />
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[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
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**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
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[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
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**[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
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[[4fea]] - hCASP catalytic domain + inhibitor<br />
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**[[4fea]] - hCASP catalytic domain + inhibitor<br />
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[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
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**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
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[[1i4o]] - hCASP P20 subunit + XIAP<br />
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**[[1i4o]] - hCASP P20 subunit + XIAP<br />
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[[4jb8]] - hCASP P20, P11 subunits + DARPIN<br />
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**[[4jb8]] - hCASP P20, P11 subunits + DARPIN<br />
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===CASP-8===
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*CASP-8
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[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
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**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
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[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br />
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**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br />
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[[1qtn]], [[4jj7]], [[4jj8]] - hCASP P18, P11 + polypeptide inhibitor<br />
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**[[1qtn]], [[4jj7]], [[4jj8]] - hCASP P18, P11 + polypeptide inhibitor<br />
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[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
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**[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
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[[2y1l]] - hCASP subunits P18 P10<br />
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**[[2y1l]] - hCASP subunits P18 P10<br />
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[[2k7z]] – hpro-CASP (mutant) – NMR<br />
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**[[2k7z]] – hpro-CASP (mutant) – NMR<br />
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[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica''
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**[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica''
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===CASP-9===
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*CASP-9
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[[2ar9]] – hCASP (mutant) <br />
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**[[2ar9]] – hCASP (mutant) <br />
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[[1jxq]] - hCASP + polypeptide inhibitor<br />
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**[[1jxq]] - hCASP + polypeptide inhibitor<br />
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[[3v3k]] – hCASP + effector protein<br />
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**[[3v3k]] – hCASP + effector protein<br />
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[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
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**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
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[[3ygs]] – hpro-CASP + APAF-1 CARD
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**[[3ygs]] – hpro-CASP + APAF-1 CARD
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===Drosophila melanogaster CASP===
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*''Drosophila melanogaster'' CASP
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[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br />
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**[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br />
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[[3sir]] - DmCASP drICE residues 78-332<br />
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**[[3sir]] - DmCASP drICE residues 78-332<br />
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[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br />
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**[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br />
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===Metacaspase===
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*Metacaspase
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[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br />
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[[4f6o]] – yMCASP 1 – yeast<br />
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[[4f6p]] – yMCASP 1 (mutant)<br />
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**[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br />
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**[[4f6o]] – yMCASP 1 – yeast<br />
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**[[4f6p]] – yMCASP 1 (mutant)<br />
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}}

Revision as of 12:57, 19 November 2014

Template:STRUCTURE 1pyo

Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.

  • CASP-1 (or Interleukin-1 beta converting enzyme, ICE) cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein.
  • CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.
  • CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in Drosophila melanogaster.
  • Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.

For some details see:
CASP-1 - Human Caspase-1
CASP-3 - Sandox Bay Serrano;

CASP-6 - Molecular Playground/Caspase-6 (new);

CASP-7 - Molecular Playground/Caspase-7 Dynamics

CASP-9 - Molecular Playground/Caspase-9 Regulation.

3D structures of caspase

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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