This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Caspase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 20: Line 20:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===CASP-1===
+
*CASP-1
-
[[3e4c]] – hpro-CASP (mutant) - human<br />
+
**[[3e4c]] – hpro-CASP (mutant) - human<br />
-
[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br />
+
**[[2nn3]] – pro-SfCASP (mutant) – ''Spodoptera frugiperda''<br />
-
[[1sc1]], [[1sc4]] - hCASP (mutant) <br />
+
**[[1sc1]], [[1sc4]] - hCASP (mutant) <br />
-
[[1sc3]] - hCASP (mutant) + malonate<br />
+
**[[1sc3]] - hCASP (mutant) + malonate<br />
-
[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br />
+
**[[3d6f]], [[3d6h]], [[3d6m]], [[1ibc]] - hCASP (mutant) + polypeptide inhibitor<br />
-
[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br />
+
**[[2hbq]], [[1bmq]], [[3ns7]] - hCASP + inhibitor<br />
-
[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br />
+
**[[2h4w]], [[2h4y]], [[2h51]], [[2h54]], [[2hbr]], [[2hby]], [[2hbz]], [[2h48]], [[2fqq]], [[1rwk]], [[1rwm]], [[1rwn]], [[1rwo]], [[1rwp]], [[1rwv]], [[1rww]], [[1rwx]] - hCASP (mutant) + inhibitor<br />
-
[[1ice]] – hCASP + tetrapeptide aldehyde<br />
+
**[[1ice]] – hCASP + tetrapeptide aldehyde<br />
-
[[1m72]] – SfCASP + polypeptide inhibitor<br />
+
**[[1m72]] – SfCASP + polypeptide inhibitor<br />
-
===CASP-2===
+
*CASP-2
-
[[2p2c]] – hCASP<br />
+
**[[2p2c]] – hCASP<br />
-
[[3r7s]] - hCASP subunits P12, P18<br />
+
**[[3r7s]] - hCASP subunits P12, P18<br />
-
[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br />
+
**[[1pyo]], [[3r5j]], [[3r6g]], [[3r6l]], [[3r7b]], [[3r7n]], [[3rjm]] - hCASP + polypeptide inhibitor<br />
-
===CASP-3===
+
*CASP-3
-
[[1qx3]] - hCASP<br />
+
**[[1qx3]] - hCASP<br />
-
[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
+
**[[2xyg]], [[2xyh]], [[2xyp]], [[4jje]] – hCASP subunits P12, P17 + inhibitor<br />
-
[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
+
**[[2xzd]], [[2xzt]], [[2y0b]] - hCASP subunits P12, P17 + DARPIN-3.4<br />
-
[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br />
+
**[[3pcx]], [[3pd1]], [[3pd0]], [[3gjq]], [[3gjr]], [[3gjs]], [[3gjt]], [[3edq]], [[3edr]], [[2cnk]], [[2cnl]], [[2cnn]], [[2cno]], [[2cdr]], [[2h65]], [[1cp3]], [[1pau]] – hCASP + polypeptide inhibitor<br />
-
[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]] – hCASP subunits P12, P17 + polypeptide inhibitor<br />
+
**[[4dcj]], [[4dco]], [[4dcp]], [[4eha]], [[4ehd]], [[4ehf]], [[4ehh]], [[4ehk]], [[4ehl]], [[4ehn]] – hCASP subunits P12, P17 + polypeptide inhibitor<br />
-
[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br />
+
**[[2dko]], [[2cjx]], [[2cjy]] - hCASP (mutant) + polypeptide inhibitor<br />
-
[[4jqy]], [[4jqz]] - hpro-CASP (mutant)<br />
+
**[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br />
-
[[3kjf]], [[3h0e]], [[3deh]], [[3dei]], [[3dej]], [[3dek]], [[1re1]], [[1rhj]], [[1rhk]], [[1rhm]], [[1rhq]], [[1rhr]], [[1rhu]], [[1nme]], [[1nmq]], [[1nms]], [[1gfw]] – hCASP + inhibitor<br />
+
**[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
-
[[3itn]], [[2j30]], [[2j31]], [[2j32]], [[2j33]], [[2c1e]], [[2c2k]], [[2c2m]], [[2c2o]], [[2c2z]], [[2h5i]], [[2h5j]], [[4jr0]] – hpro-CASP + polypeptide inhibitor<br />
+
**[[1i3o]] - hCASP (mutant) + XIAP-BIR2
-
[[1i3o]] - hCASP (mutant) + XIAP-BIR2
+
-
===CASP-6===
+
*CASP-6
-
[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br />
+
**[[3p45]], [[3k7e]], [[2wdp]] – hCASP<br />
-
[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]] – hCASP (mutant) <br />
+
**[[3nkf]], [[3nr2]], [[3s8e]], [[3v6l]], [[3v6m]], [[4iyr]] – hCASP (mutant) <br />
-
[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
+
**[[3od5]], [[3p4u]], [[3qnw]], [[3s70]] – hCASP + polypeptide inhibitor<br />
-
[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
+
**[[4ejf]] – hCASP subunit P11 + P18 + polypeptide<br />
-
[[4fxo]] - hCASP subunit P11 + P18 + Zn<br />
+
**[[4fxo]] - hCASP subunit P11 + P18 + Zn<br />
-
[[4hva]] - hCASP subunit P11 + P18 + VEID inhibitor<br />
+
**[[4hva]] - hCASP subunit P11 + P18 + VEID inhibitor<br />
-
[[4n5d]] - hCASP subunit P11 + P18 + inhibitor<br />
+
**[[4n5d]] - hCASP subunit P11 + P18 + inhibitor<br />
-
[[4n6g]], [[4n7j]], [[4n7m]], [[4nbk]], [[4nbl]], [[4nbn]] - hCASP subunit P11 + P18 (mutant) + inhibitor<br />
+
**[[4n6g]], [[4n7j]], [[4n7m]], [[4nbk]], [[4nbl]], [[4nbn]] - hCASP subunit P11 + P18 (mutant) + inhibitor<br />
-
===CASP-7===
+
*CASP-7
-
[[3rk5]], [[4fdi]] - hCASP<br />
+
**[[3rk5]], [[4fdi]] - hCASP<br />
-
[[3ibf]] – hCASP P20 subunit<br />
+
**[[3ibf]] – hCASP P20 subunit<br />
-
[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
+
**[[3r5k]], [[4hq0]] - hCASP (mutant) <br />
-
[[1k86]], [[1gqf]] – hCASP catalytic domain<br />
+
**[[1k86]], [[1gqf]] – hCASP catalytic domain<br />
-
[[1k88]] – hpro-CASP (mutant) <br />
+
**[[1k88]] – hpro-CASP (mutant) <br />
-
[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br />
+
**[[3ibc]], [[2ql5]], [[2ql7]], [[2ql9]], [[2qlb]], [[2qlf]], [[2qlj]], [[3edr]] - hCASP P20 subunit + polypeptide inhibitor<br />
-
[[1f1j]] - hCASP + polypeptide inhibitor<br />
+
**[[1f1j]] - hCASP + polypeptide inhibitor<br />
-
[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
+
**[[3h1p]], [[4jr1]], [[4jr2]] - hCASP catalytic domain (mutant) + polypeptide inhibitor<br />
-
[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
+
**[[1shj]], [[1shl]] - hCASP catalytic domain (mutant) + inhibitor<br />
-
[[4fea]] - hCASP catalytic domain + inhibitor<br />
+
**[[4fea]] - hCASP catalytic domain + inhibitor<br />
-
[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
+
**[[1i51]], [[1kmc]] - hCASP (mutant) + XIAP-BIR2<br />
-
[[1i4o]] - hCASP P20 subunit + XIAP<br />
+
**[[1i4o]] - hCASP P20 subunit + XIAP<br />
-
[[4jb8]] - hCASP P20, P11 subunits + DARPIN<br />
+
**[[4jb8]] - hCASP P20, P11 subunits + DARPIN<br />
-
===CASP-8===
+
*CASP-8
-
[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
+
**[[3kjn]], [[3kjq]] – hCASP subunit P18 + inhibitor<br />
-
[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br />
+
**[[1f9e]], [[1qtn]], [[1qdu]] - hCASP subunit α,β + polypeptide inhibitor<br />
-
[[1qtn]], [[4jj7]], [[4jj8]] - hCASP P18, P11 + polypeptide inhibitor<br />
+
**[[1qtn]], [[4jj7]], [[4jj8]] - hCASP P18, P11 + polypeptide inhibitor<br />
-
[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
+
**[[3h11]] - hCASP (mutant) + polypeptide inhibitor<br />
-
[[2y1l]] - hCASP subunits P18 P10<br />
+
**[[2y1l]] - hCASP subunits P18 P10<br />
-
[[2k7z]] – hpro-CASP (mutant) – NMR<br />
+
**[[2k7z]] – hpro-CASP (mutant) – NMR<br />
-
[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica''
+
**[[2fun]], [[1i4e]] – CASP + P35 – ''Autographa californica''
-
===CASP-9===
+
*CASP-9
-
[[2ar9]] – hCASP (mutant) <br />
+
**[[2ar9]] – hCASP (mutant) <br />
-
[[1jxq]] - hCASP + polypeptide inhibitor<br />
+
**[[1jxq]] - hCASP + polypeptide inhibitor<br />
-
[[3v3k]] – hCASP + effector protein<br />
+
**[[3v3k]] – hCASP + effector protein<br />
-
[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
+
**[[1nw9]] – hCASP catalytic domain + XIAP-BIR3<br />
-
[[3ygs]] – hpro-CASP + APAF-1 CARD
+
**[[3ygs]] – hpro-CASP + APAF-1 CARD
-
===Drosophila melanogaster CASP===
+
*''Drosophila melanogaster'' CASP
-
[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br />
+
**[[2fp3]] – DmCASP Dronc residues 136-450 – ''Drosophila melanogaster''<br />
-
[[3sir]] - DmCASP drICE residues 78-332<br />
+
**[[3sir]] - DmCASP drICE residues 78-332<br />
-
[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br />
+
**[[3sip]] – DmCASP drICE residues 78-230 + apoptosis inhibitor<br />
-
===Metacaspase===
+
*Metacaspase
-
 
+
-
[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br />
+
-
[[4f6o]] – yMCASP 1 – yeast<br />
+
-
[[4f6p]] – yMCASP 1 (mutant)<br />
+
 +
**[[4afp]], [[4afr]], [[4afv]], [[4af8]] – MCASP (mutant) – ''Trypanosom brucei''<br />
 +
**[[4f6o]] – yMCASP 1 – yeast<br />
 +
**[[4f6p]] – yMCASP 1 (mutant)<br />
 +
}}

Revision as of 12:57, 19 November 2014

Template:STRUCTURE 1pyo

Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.

  • CASP-1 (or Interleukin-1 beta converting enzyme, ICE) cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein.
  • CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.
  • CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in Drosophila melanogaster.
  • Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.

For some details see:
CASP-1 - Human Caspase-1
CASP-3 - Sandox Bay Serrano;

CASP-6 - Molecular Playground/Caspase-6 (new);

CASP-7 - Molecular Playground/Caspase-7 Dynamics

CASP-9 - Molecular Playground/Caspase-9 Regulation.

3D structures of caspase

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Caspase"
Personal tools