Dual specificity protein kinase

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[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
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[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]] - hTTK kinase domain + inhibitor
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[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]], [[4js8]], [[4jt3]] - hTTK kinase domain + inhibitor
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[[2zmc]] - hTTK catalytic domain
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[[2zmc]] - hTTK kinase domain
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[[2zmd]] - hTTK catalytic domain (mutant) + inhibitor
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[[2zmd]] - hTTK kinase domain (mutant) + inhibitor
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[[3hmn]] - hTTK catalytic domain + ATP
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[[3hmn]] - hTTK kinase domain + ATP
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[[3hmo]] - hTTK catalytic domain + staurosporine
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[[3hmo]] - hTTK kinase domain + staurosporine
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[[3hmp]] - hTTK catalytic domain + quinazolin ligand
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[[3hmp]] - hTTK kinase domain + quinazolin ligand
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:03, 26 August 2014

Template:STRUCTURE 2x9e

Dual specificity protein kinases are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing. The dual specificity protein kinase TTK contains tetra-trico-peptide repeat domain (TPR) which serves as interaction domain between proteins.

Contents

3D structures of dual specificity protein kinase

Updated on 26-August-2014

CLK1

1z57 – hCLK1 kinase domain + himenialdizine – human

2vag - hCLK1 kinase domain + indole inhibitor

CLK2

3nr9 – hCLK2 kinase domain

CLK3

2eu9 – hCLK3

2exe – hCLK3 kinase domain, phosphorylated

2wu6, 2wu7 – hCLK3 kinase domain + inhibitor

3raw - hCLK3 kinase domain + leucettine

TTK

3cek, 3dbq – hTTK kinase domain
4b94, 4h7x, 4h7y - hTTK TPR domain
3gfw - hTTK kinase domain + pyrolo-pyridin ligand

3h9f - hTTK kinase domain + pyrimidino-diazepin ligand

2x9e, 3vqu, 3w1f, 4bhz, 4bi0, 4bi1, 4bi2, 4c4e, 4c4f, 4c4g, 4c4h, 4c4i, 4c4j, 4js8, 4jt3 - hTTK kinase domain + inhibitor

2zmc - hTTK kinase domain

2zmd - hTTK kinase domain (mutant) + inhibitor

3hmn - hTTK kinase domain + ATP

3hmo - hTTK kinase domain + staurosporine

3hmp - hTTK kinase domain + quinazolin ligand

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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