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Ephrin receptor

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Ephrin A1 receptor===
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*Ephrin A1 receptor
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[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
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**[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
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[[3hil]] - hEPH A1 SAM<br />
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**[[3hil]] - hEPH A1 SAM<br />
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[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
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**[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
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[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
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**[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
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===Ephrin A2 receptor===
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*Ephrin A2 receptor
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[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
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**[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
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[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
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**[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
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[[2k9y]], [[2e8n]] - hEPH A2 transmembrane domain – NMR<BR />
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**[[2k9y]], [[2e8n]] - hEPH A2 transmembrane domain – NMR<BR />
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[[1mqb]] - hEPH A2 kinase domain<BR />
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**[[1mqb]] - hEPH A2 kinase domain<BR />
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''Ephrin A2 receptor binary complex''<br />
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*''Ephrin A2 receptor binary complex''<br />
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[[3mx0]], [[2x11]] - hEPH A2 ectodomain + ephrin A5<BR />
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**[[3mx0]], [[2x11]] - hEPH A2 ectodomain + ephrin A5<BR />
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[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
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**[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
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[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
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**[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
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[[2kso]] - hEPH A2 SAM + SHIP2<br />
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**[[2kso]] - hEPH A2 SAM + SHIP2<br />
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===Ephrin A3 receptor===
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*Ephrin A3 receptor
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[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
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**[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
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[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPH A3 kinase domain (mutant) <BR />
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**[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPH A3 kinase domain (mutant) <BR />
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[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
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**[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
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[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
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**[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
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[[3dzq]] - hEPH A3 kinase domain + inhibitor<br />
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**[[3dzq]] - hEPH A3 kinase domain + inhibitor<br />
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[[4g2f]] - hEPH A3 kinase domain (mutant) + inhibitor<br />
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**[[4g2f]] - hEPH A3 kinase domain (mutant) + inhibitor<br />
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===Ephrin A4 receptor===
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*Ephrin A4 receptor
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[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
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**[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
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[[4bk4]], [[4m4p]] - hEPH A4 ectodomain<br />
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**[[4bk4]], [[4m4p]] - hEPH A4 ectodomain<br />
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[[2lw8]] - hEPH A4 LBD – NMR<br />
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**[[2lw8]] - hEPH A4 LBD – NMR<br />
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[[2hel]] – mEPH A4 membrane and kinase domains – mouse<br />
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**[[2hel]] – mEPH A4 membrane and kinase domains – mouse<br />
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[[2y6m]] – mEPH A4 kinase domain<br />
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**[[2y6m]] – mEPH A4 kinase domain<br />
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''Ephrin A4 receptor binary complex''<br />
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*''Ephrin A4 receptor binary complex''<br />
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[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
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**[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
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[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain<br />
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**[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain<br />
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[[4bk5]], [[4bka]], [[4m4r]] - hEPH A4 ectodomain + ephrin A5 LBD<br />
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**[[4bk5]], [[4bka]], [[4m4r]] - hEPH A4 ectodomain + ephrin A5 LBD<br />
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[[4bkf]] - hEPH A4 ectodomain + ephrin B3 LBD<br />
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**[[4bkf]] - hEPH A4 ectodomain + ephrin B3 LBD<br />
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[[2xyu]] – mEPH A4 kinase domain + inhibitor<br />
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**[[2xyu]] – mEPH A4 kinase domain + inhibitor<br />
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[[2y6o]] – mEPH A4 kinase domain + cancer drug<br />
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**[[2y6o]] – mEPH A4 kinase domain + cancer drug<br />
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===Ephrin A5 receptor===
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*Ephrin A5 receptor
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[[2r2p]] - hEPH A5 kinase domain<BR />
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**[[2r2p]] - hEPH A5 kinase domain<BR />
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[[1shx]] - mEPH A5 <br />
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**[[1shx]] - mEPH A5 <br />
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[[4et7]] – hEPH A5 (mutant)<br />
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**[[4et7]] – hEPH A5 (mutant)<br />
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===Ephrin A7 receptor===
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*Ephrin A7 receptor
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[[3nru]] – hEPH A7 LBD<BR />
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**[[3nru]] – hEPH A7 LBD<BR />
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[[3h8m]] – hEPH A7 SAM<BR />
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**[[3h8m]] – hEPH A7 SAM<BR />
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[[2rei]] - hEPH A7 kinase domain<BR />
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**[[2rei]] - hEPH A7 kinase domain<BR />
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[[3dko]] – hEPH A7 kinase domain + inhibitor
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**[[3dko]] – hEPH A7 kinase domain + inhibitor
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===Ephrin A8 receptor===
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*Ephrin A8 receptor
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[[3kul]] - hEPH A8 kinase domain<BR />
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**[[3kul]] - hEPH A8 kinase domain<BR />
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[[1x5l]] – hEPH A8 fn3 domain – NMR<BR />
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**[[1x5l]] – hEPH A8 fn3 domain – NMR<BR />
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[[1ucv]] - hEPH A8 SAM – NMR<BR />
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**[[1ucv]] - hEPH A8 SAM – NMR<BR />
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===Ephrin B1 receptor===
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*Ephrin B1 receptor
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[[2eao]] – hEPH B1 SAM – NMR<BR />
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**[[2eao]] – hEPH B1 SAM – NMR<BR />
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[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
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**[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
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[[3zfx]] - hEPH B1 kinase domain<br />
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**[[3zfx]] - hEPH B1 kinase domain<br />
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===Ephrin B2 receptor===
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*Ephrin B2 receptor
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[[3etp]] – hEPH B2<BR />
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**[[3etp]] – hEPH B2<BR />
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[[1f0m]] – mEPH B2 SAM<BR />
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**[[1f0m]] – mEPH B2 SAM<BR />
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[[1iko]] - mEPH B2 ectodomain<br />
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**[[1iko]] - mEPH B2 ectodomain<br />
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[[2i85]] - hEPH B2 ectodomain<br />
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**[[2i85]] - hEPH B2 ectodomain<br />
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[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
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**[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
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''Ephrin B2 receptor binary complex''<br />
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*''Ephrin B2 receptor binary complex''<br />
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[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
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**[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
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[[2qbx]] – hEPH B2 + peptide agonist<BR />
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**[[2qbx]] – hEPH B2 + peptide agonist<BR />
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[[2hen]] - hEPH B2 kinase domain + ADP<BR />
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**[[2hen]] - hEPH B2 kinase domain + ADP<BR />
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[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
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**[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
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[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
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**[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
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===Ephrin B3 receptor===
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*Ephrin B3 receptor
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[[3p1i]] – hEPH B3 LBD<BR />
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**[[3p1i]] – hEPH B3 LBD<BR />
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[[3zfy]] - hEPH B3 kinase domain<br />
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**[[3zfy]] - hEPH B3 kinase domain<br />
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===Ephrin B4 receptor===
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*Ephrin B4 receptor
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[[2qkq]] – hEPH B4 SAM<BR />
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**[[2qkq]] – hEPH B4 SAM<BR />
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[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
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**[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
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[[2x9f]], [[2vwy]] - hEPH B4 kinase domain (mutant) <BR />
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**[[2x9f]], [[2vwy]] - hEPH B4 kinase domain (mutant) <BR />
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''Ephrin B4 receptor binary complex''<br />
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*''Ephrin B4 receptor binary complex''<br />
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[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPH B4 kinase domain + inhibitor <BR />
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[[3zew]] - hEPH B4 + staurosporine<br />
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[[2xvd]], [[2yn8]], [[4bb4]] - hEPH B4 kinase domain (mutant) + inhibitor<br />
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[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
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**[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPH B4 kinase domain + inhibitor <BR />
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**[[3zew]] - hEPH B4 + staurosporine<br />
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**[[2xvd]], [[2yn8]], [[4bb4]] - hEPH B4 kinase domain (mutant) + inhibitor<br />
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**[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
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}}

Revision as of 11:31, 24 November 2014

Image:3hei.png
Crystal Structure of ephrin A2 receptor complex with ephrin, 3hei

Template:STRUCTURE 3fxx

Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see Ephrin Type-A Receptor.

3D Structures of ephrin receptors

Updated on 24-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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