This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Farnesyltransferase
From Proteopedia
(Difference between revisions)
| Line 11: | Line 11: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *FTase | |
| - | [[1ft1]] – rFTase – rat<br /> | + | **[[1ft1]] – rFTase – rat<br /> |
| - | [[3q73]] – CnFTase – ''Cryptococcus neoformans'' | + | **[[3q73]] – CnFTase – ''Cryptococcus neoformans'' |
| - | + | *FTase binary complex with FPP | |
| - | [[1ft2]], [[1fpp]] – rFTase + FPP<BR /> | + | **[[1ft2]], [[1fpp]] – rFTase + FPP<BR /> |
| - | [[1o1r]], [[1o1s]], [[3ksl]], [[3ksq]] - rFTase + FPP-analog<br /> | + | **[[1o1r]], [[1o1s]], [[3ksl]], [[3ksq]] - rFTase + FPP-analog<br /> |
| - | + | *FTase binary complex with peptide | |
| - | [[1kzp]], [[1o1t]] - rFTase + farnesylated peptide<br /> | + | **[[1kzp]], [[1o1t]] - rFTase + farnesylated peptide<br /> |
| - | [[2h6f]] - hFTase + farnesylated peptide<br /> | + | **[[2h6f]] - hFTase + farnesylated peptide<br /> |
| - | [[2h6g]], [[2h6h]], [[2h6i]] - hFTase α subunit + β subunit (mutant) + farnesylated peptide<br /> | + | **[[2h6g]], [[2h6h]], [[2h6i]] - hFTase α subunit + β subunit (mutant) + farnesylated peptide<br /> |
| - | [[3q79]] - CnFTase + farnesylated peptide | + | **[[3q79]] - CnFTase + farnesylated peptide |
| - | + | *FTase binary complex with inhibitor | |
| - | [[3eu5]] – rFTase + biotin-GPP<br /> | + | **[[3eu5]] – rFTase + biotin-GPP<br /> |
| - | [[3euv]] - rFTase α subunit + β subunit (mutant)+ biotin-GPP<br /> | + | **[[3euv]] - rFTase α subunit + β subunit (mutant)+ biotin-GPP<br /> |
| - | [[1n94]], [[1n95]], [[1n9a]], [[1o5m]], [[1ni1]], [[1x81]], [[2bed]], [[2r2l]] - rFTase + inhibitor<br /> | + | **[[1n94]], [[1n95]], [[1n9a]], [[1o5m]], [[1ni1]], [[1x81]], [[2bed]], [[2r2l]] - rFTase + inhibitor<br /> |
| - | [[1nl4]] - rFTase α subunit (mutant) + β subunit + inhibitor | + | **[[1nl4]] - rFTase α subunit (mutant) + β subunit + inhibitor |
| - | + | *FTase ternary complex with FPP and peptide | |
| - | [[1d8d]], [[1tn8]] - rFTase + Ras peptide + FPP-analog<br /> | + | **[[1d8d]], [[1tn8]] - rFTase + Ras peptide + FPP-analog<br /> |
| - | [[1kzo]] - rFTase + farnesylated Ras peptide + FPP<BR /> | + | **[[1kzo]] - rFTase + farnesylated Ras peptide + FPP<BR /> |
| - | [[1tn7]], [[3dpy]] - rFTase + peptide + FPP-analog<BR /> | + | **[[1tn7]], [[3dpy]] - rFTase + peptide + FPP-analog<BR /> |
| - | [[1jcr]], [[1jcs]] - rFTase + tetrapeptide inhibitor + FPP<BR /> | + | **[[1jcr]], [[1jcs]] - rFTase + tetrapeptide inhibitor + FPP<BR /> |
| - | [[1d8e]] - rFTase no Zn + Ras peptide + FPP-analog<br /> | + | **[[1d8e]] - rFTase no Zn + Ras peptide + FPP-analog<br /> |
| - | [[1tn6]] - hFTase + Rap2a peptide + FPP-analog<br /> | + | **[[1tn6]] - hFTase + Rap2a peptide + FPP-analog<br /> |
| - | [[3q75]], [[3q78]] - CnFTase + peptide + FPP-analog<br /> | + | **[[3q75]], [[3q78]] - CnFTase + peptide + FPP-analog<br /> |
| - | [[4l9p]] - AfFTase + peptide + FPP-analog – ''Apergillus fumigatus''<br /> | + | **[[4l9p]] - AfFTase + peptide + FPP-analog – ''Apergillus fumigatus''<br /> |
| - | + | *FTase ternary complex with FPP and inhibitor | |
| - | [[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> | + | **[[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> |
| - | [[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> | + | **[[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> |
| - | [[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> | + | **[[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> |
| - | [[1ld7]], [[1ld8]], [[1mzc]], [[1sa4]], [[1s63]], [[2f0y]] - hFTase + inhibitor + FPP<BR /> | + | **[[1ld7]], [[1ld8]], [[1mzc]], [[1sa4]], [[1s63]], [[2f0y]] - hFTase + inhibitor + FPP<BR /> |
| - | [[2iej]] - hFTase + inhibitor + FPP-analog<br /> | + | **[[2iej]] - hFTase + inhibitor + FPP-analog<br /> |
| - | [[3pz4]] - FTase + inhibitor + FPP – mouse<br /> | + | **[[3pz4]] - FTase + inhibitor + FPP – mouse<br /> |
| - | [[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> | + | **[[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> |
| - | [[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> | + | **[[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> |
| - | [[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> | + | **[[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> |
| - | + | *FTase ternary complex with GPP and protein | |
| + | **[[1n4p]], [[1n4r]], [[1n4s]] - rFTase α subunit + GTase β subunit + transforming protein + GPP<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:49, 24 November 2014
Farnesyltransferase (FTase) is part of the prenyltransferase group. FTase modifies proteins by adding farnesyl diphosphate (FPP) – an isoprenoid lipid – to a cysteine near the C terminal. This addition forms a thioether linkage, makes the protein more hydrophobic and associates it with the membrane. Farnesylated proteins – like those of the Ras family - are involved in cellular signaling. Thus, FTase inhibitors are being tested as anti-cancer agents. FTase are composed of 2 subunits. The β subunit coordinates a Zn atom.
3D structures of farnesyltransferase
Updated on 24-November-2014
