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Fibronectin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== Fn module FnI ===
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* Fn module FnI
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[[3m7p]] – hFn GBD – human<br />
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**[[3m7p]] – hFn GBD – human<br />
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[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
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**[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
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[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
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**[[3gxe]], [[3ejh]] – hFn 8-9FnI+collagen alpha-1<br />
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[[1fbr]] - hFn 4-5FnI - NMR<br />
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**[[1fbr]] - hFn 4-5FnI - NMR<br />
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[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
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**[[2rky]], [[2rl0]] – hFn 4-5FnI+Fn binding peptide<br />
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[[2rkz]], [[3cal]], [[3zrz]] - hFn 2-3FnI+Fn binding peptide<br />
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**[[2rkz]], [[3cal]], [[3zrz]] - hFn 2-3FnI+Fn binding peptide<br />
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[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
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**[[2cg6]], [[2cg7]] - hFn 2-3FnI<br />
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[[2cku]] - hFn 2-3FnI – NMR<br />
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**[[2cku]] - hFn 2-3FnI – NMR<br />
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[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
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**[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br />
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[[2ec3]] – hFn 11FnI – NMR<br />
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**[[2ec3]] – hFn 11FnI – NMR<br />
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[[3r8q]] – hFn 12-14FnI<br />
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**[[3r8q]] – hFn 12-14FnI<br />
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[[1qgb]] – hFn FnI N-terminal - NMR<br />
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**[[1qgb]] – hFn FnI N-terminal - NMR<br />
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[[2ck2]] – hFn (mutant) core swapped<br />
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**[[2ck2]] – hFn (mutant) core swapped<br />
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[[1j8k]] – hFn extra domain 2 – NMR<br />
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**[[1j8k]] – hFn extra domain 2 – NMR<br />
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[[1fnh]] – hFn heparin and integrin binding domains<br />
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**[[1fnh]] – hFn heparin and integrin binding domains<br />
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[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
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**[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
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[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
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**[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
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=== Fn module FnII ===
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* Fn module FnII
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[[2fn2]] – hFn 2FnII – NMR
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**[[2fn2]] – hFn 2FnII – NMR
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=== Fn module FnIII ===
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* Fn module FnIII
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[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
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**[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
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[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
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**[[2h41]], [[2h45]] – hFn 2FnIII – NMR<br />
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[[1oww]] - hFn 1FnIII – NMR<br />
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**[[1oww]] - hFn 1FnIII – NMR<br />
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[[2ha1]] - hFn 1-2FnIII – NMR<br />
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**[[2ha1]] - hFn 1-2FnIII – NMR<br />
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[[2crm]] - hFn 4FnIII – NMR<br />
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**[[2crm]] - hFn 4FnIII – NMR<br />
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[[2crz]] - hFn 5FnIII – NMR<br />
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**[[2crz]] - hFn 5FnIII – NMR<br />
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[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
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**[[1fna]], [[1ttf]], [[1ttg]] – hFn 10FnIII<br />
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[[2ocf]] - hFn 10FnIII+estrogen receptor ligand-binding domain<br />
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**[[2ocf]] - hFn 10FnIII+estrogen receptor ligand-binding domain<br />
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[[1fnf]] – hFn 7-10FnIII<br />
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**[[1fnf]] – hFn 7-10FnIII<br />
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[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
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**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
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[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br />
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**[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br />
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[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
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**[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
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=== Fn module FnI+FnII ===
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* Fn module FnI+FnII
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[[3mql]] – hFn 6FnI+2FnII+7FnI
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**[[3mql]] – hFn 6FnI+2FnII+7FnI
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:52, 25 November 2014

Image:1fbr.png
Crystal Structure of Fibronectin 4-5FnI fragment 1fbr

Template:STRUCTURE 3m7p


















Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).

3D Structures of Fibronectin

Updated on 25-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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