Glyoxalase
From Proteopedia
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{{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | {{STRUCTURE_1qin| PDB=1qin | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion, [[1qin]] }} | ||
| - | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. | + | '''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism. <br /> |
| + | * '''GLO1''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br /> | ||
| + | * '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see [[Leishmania infantum Glyoxalase II]]. | ||
==3D structures of glyoxalase== | ==3D structures of glyoxalase== | ||
Revision as of 09:31, 27 August 2014
Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism.
- GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
- GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.
Contents |
3D structures of glyoxalase
Updated on 27-August-2014
Glyoxalase 1
1bh5 – hGLO (mutant) – human
1fa8 – EcGLO – Escherichia coli
2c21 – GLO – Leishmania major
1fro – hGLO + benzyl glutathione
1qin, 1qip - hGLO + glutathione derivative
1f9z, 1fa5, 1fa6, 1fa7 – EcGLO + metal
2za0 – GLO + methyl gerfelin – mouse
3hdp – GLO + Ni – Clostridium acetobutylicum
Glyoxalase 2
1xm8 – GLO – Arabidopsis thaliana
2p18 - LiGLO – Leishmania infantum
1qh3 – hGLO + actate + cacodylate
1qh5 – hGLO + glutathione derivative
2p1e – LiGLO + lactate
Glyoxalase 3
4lru – GLO – Candida albicans
