Hydroxysteroid dehydrogenase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===3-α HSD===
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*3-α HSD
'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
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[[1ral]] – rHSD – rat<BR />
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**[[1ral]] – rHSD – rat<BR />
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[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
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**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
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[[3fjn]] - mHSD (mutant) - mouse<br />
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**[[3fjn]] - mHSD (mutant) - mouse<br />
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[[4is2]] – CsHSD – ''Clostridium scindens''<br />
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**[[4is2]] – CsHSD – ''Clostridium scindens''<br />
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''3-α HSD binary complex''
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*''3-α HSD binary complex''
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[[1lwi]] – rHSD + NADP<BR />
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**[[1lwi]] – rHSD + NADP<BR />
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[[1fk8]] – CtHSD + NAD<BR />
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**[[1fk8]] – CtHSD + NAD<BR />
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[[2fvl]], [[2hdj]] - hHSD + NADP<BR />
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**[[2fvl]], [[2hdj]] - hHSD + NADP<BR />
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[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />
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**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />
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[[2p5n]] - mHSD + NADP<BR />
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**[[2p5n]] - mHSD + NADP<BR />
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[[4is3]] - CsHSD + NAD<br />
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**[[4is3]] - CsHSD + NAD<br />
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''3-α HSD ternary complex''
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*''3-α HSD ternary complex''
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[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP – human<BR />
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**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP – human<BR />
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[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
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**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
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[[2ipf]] - mHSD + hydroxysteroid + NADP<BR />
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**[[2ipf]] - mHSD + hydroxysteroid + NADP<BR />
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[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<BR />
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**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<BR />
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[[3cv6]] - mHSD (mutant) + inhibitor + NADP<BR />
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**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<BR />
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===7-α HSD===
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*7-α HSD
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[[3gaf]] - HSD – ''Brucella melitensis''<BR />
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**[[3gaf]] - HSD – ''Brucella melitensis''<BR />
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[[1ahh]] – EcHSD + NAD – ''Escherichia coli''<BR />
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**[[1ahh]] – EcHSD + NAD – ''Escherichia coli''<BR />
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[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD
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**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD
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===20-α HSD===
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*20-α HSD
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[[1q5m]] - raHSD + NADP – rabbit
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**[[1q5m]] - raHSD + NADP – rabbit
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''20-α HSD ternary complex''
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*''20-α HSD ternary complex''
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[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
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**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
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[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />
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**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />
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[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />
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**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />
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[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
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**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
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===11-β HSD===
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*11-β HSD
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[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
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**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
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[[2pd6]] - hHSD + NAD<BR />
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**[[2pd6]] - hHSD + NAD<BR />
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[[1y5m]] - mHSD + NADP<BR />
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**[[1y5m]] - mHSD + NADP<BR />
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[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
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**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
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[[3hb4]] - hHSD + inhibitor<BR />
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**[[3hb4]] - hHSD + inhibitor<BR />
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[[3dey]] - hHSD + hydroxysteroid<BR />
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**[[3dey]] - hHSD + hydroxysteroid<BR />
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[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
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**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
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''11-β HSD ternary complex''
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*''11-β HSD ternary complex''
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[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
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**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
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[[1y5r]], [[3gmd]] - mHSD + hydroxysteroid + NADP<BR />
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**[[1y5r]], [[3gmd]] - mHSD + hydroxysteroid + NADP<BR />
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[[2bel]] - hHSD + hydroxysteroid + NADP<BR />
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**[[2bel]] - hHSD + hydroxysteroid + NADP<BR />
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[[2irw]], [[2ilt]] - hHSD + inhibitor + NADP<BR />
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**[[2irw]], [[2ilt]] - hHSD + inhibitor + NADP<BR />
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[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]] - hHSD (mutant) + inhibitor + NADP<BR />
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**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]] - hHSD (mutant) + inhibitor + NADP<BR />
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===17-β HSD===
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*17-β HSD
'''For 17-β HSD type 5 see''' [[Prostaglandin F synthase]]
'''For 17-β HSD type 5 see''' [[Prostaglandin F synthase]]
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[[1bhs]] – hHSD <BR />
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**[[1bhs]] – hHSD <BR />
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[[1s9c]] - hHSD (mutant) <BR />
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**[[1s9c]] - hHSD (mutant) <BR />
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[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
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**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
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[[3itd]] - ClHSD (mutant)
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**[[3itd]] - ClHSD (mutant)
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''17-β HSD binary complex''
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*''17-β HSD binary complex''
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[[3qwf]] - ClHSD + NADP<BR />
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**[[3qwf]] - ClHSD + NADP<BR />
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[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
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**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
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[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
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**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
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[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid
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**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid
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[[1fdv]] - hHSD (mutant) + NAD<BR />
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**[[1fdv]] - hHSD (mutant) + NAD<BR />
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[[1zbq]] - hHSD + NAD<BR />
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**[[1zbq]] - hHSD + NAD<BR />
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[[1qyv]] - hHSD + NADP<BR />
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**[[1qyv]] - hHSD + NADP<BR />
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[[1i5r]] - hHSD + inhibitor
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**[[1i5r]] - hHSD + inhibitor
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''17-β HSD ternary complex''
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*''17-β HSD ternary complex''
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[[1qyw]], [[1qyx]], [[1fdt]] - hHSD + hydroxysteroid + NADP<BR />
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**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD + hydroxysteroid + NADP<BR />
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[[1a27]], [[1fdu]] - hHSD (mutant) + hydroxysteroid + NADP<BR />
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**[[1a27]], [[1fdu]] - hHSD (mutant) + hydroxysteroid + NADP<BR />
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[[3hb5]] - hHSD + inhibitor + NADP<BR />
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**[[3hb5]] - hHSD + inhibitor + NADP<BR />
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[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />
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**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />
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===3-α 20-β HSD===
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*3-α 20-β HSD
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[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
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**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
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[[1hdc]] – SeHSD + inhibitor
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**[[1hdc]] – SeHSD + inhibitor
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===3-β/17-β HSD===
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*3-β/17-β HSD
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[[1hxh ]] - CtHSD
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**[[1hxh ]] - CtHSD
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:31, 27 November 2014

Template:STRUCTURE 1lwi Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of carbon it is acting on.

  • 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
  • 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.
  • 20-α HSD is involved in the control of progesterone level in pregnancy of mice.
  • 11-β HSD converts 11-keto products like cortisone to cortisol.
  • 17-β HSD is involved in the conversion of androstenedione to testosterone.
  • 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.

NAD and NADP are cofactors of HSD.

3D structures of hydroxysteroid dehydrogenase

Updated on 27-November-2014

For 3-α HSD type 2 see Prostaglandin F synthase

For 17-β HSD type 5 see Prostaglandin F synthase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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