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Interleukin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===IL-1 α===
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*IL-1 α
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[[2ila]] - hIL-1 α - human<BR />
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**[[2ila]] - hIL-1 α - human<BR />
-
[[2kki]] - hIL-1 α residues 121-271 <BR />
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**[[2kki]] - hIL-1 α residues 121-271 <BR />
-
[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR<BR />
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**[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR<BR />
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===IL-1 β===
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*IL-1 β
-
[[2wry]] - cIL-1 β – chicken<BR />
+
**[[2wry]] - cIL-1 β – chicken<BR />
-
[[3nj5]] – cIL-1 β (mutant) <BR />
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**[[3nj5]] – cIL-1 β (mutant) <BR />
-
[[2nvh]], [[9ilb]], [[1iob]], [[5i1b]], [[2i1b]], [[4i1b]], [[1i1b]] - hIL-1 β
+
**[[2nvh]], [[9ilb]], [[1iob]], [[5i1b]], [[2i1b]], [[4i1b]], [[1i1b]] - hIL-1 β
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[[1tp0]], [[1t4q]], [[1too]], [[1twe]], [[1twm]], [[1s0l]], [[1l2h]], [[1hib]], [[21bi]], [[31bi]], [[41bi]] - hIL-1 β (mutant) <BR />
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**[[1tp0]], [[1t4q]], [[1too]], [[1twe]], [[1twm]], [[1s0l]], [[1l2h]], [[1hib]], [[21bi]], [[31bi]], [[41bi]] - hIL-1 β (mutant) <BR />
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[[6i1b]], [[7i1b]] - hIL-1 β - NMR<BR />
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**[[6i1b]], [[7i1b]] - hIL-1 β - NMR<BR />
-
[[3ltq]] - hIL-1 β residues 117-269 <BR />
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**[[3ltq]] - hIL-1 β residues 117-269 <BR />
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[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
+
**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
-
[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
+
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
-
[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
+
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
-
[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
+
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
-
[[4g6j]], [[4g6m]] - hIL-1 β + antibody<br />
+
**[[4g6j]], [[4g6m]] - hIL-1 β + antibody<br />
-
[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
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**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
-
[[1md6]] – mIL-1F5 – mouse<BR />
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**[[1md6]] – mIL-1F5 – mouse<BR />
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[[2mib]], [[8i1b]] - mIL-1 β
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**[[2mib]], [[8i1b]] - mIL-1 β
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===IL-2 (T-cell growth factor)===
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*IL-2 (T-cell growth factor)
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[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
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**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
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[[3qb1]] - hIL-2 (mutant)<br />
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**[[3qb1]] - hIL-2 (mutant)<br />
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[[1irl]] – hIL-2 (mutant) - NMR<BR />
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**[[1irl]] – hIL-2 (mutant) - NMR<BR />
-
[[2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ<BR />
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**[[2erj]], [[2b5i]] - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ<BR />
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[[1z92]] - hIL-2 + IL-2 receptor α<BR />
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**[[1z92]] - hIL-2 + IL-2 receptor α<BR />
-
[[3qaz]] - hIL-2 + IL-2 receptor β and γ<BR />
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**[[3qaz]] - hIL-2 + IL-2 receptor β and γ<BR />
-
[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
+
**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
-
[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
+
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
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===IL-3===
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*IL-3
-
[[1jli]] – hIL-3 (mutant) – NMR<BR />
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**[[1jli]] – hIL-3 (mutant) – NMR<BR />
-
[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
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**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
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===IL-4===
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*IL-4
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[[2b8u]], [[1hik]], [[2int]], [[1rcb]] – hIL-4<BR />
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**[[2b8u]], [[1hik]], [[2int]], [[1rcb]] – hIL-4<BR />
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[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
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**[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
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[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
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**[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
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[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
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**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
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[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
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**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
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[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
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**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
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[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
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**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
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===IL-5===
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*IL-5
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[[1hul]] – hIL-5<BR />
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**[[1hul]] – hIL-5<BR />
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[[3b5k]] – mIL-5<br />
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**[[3b5k]] – mIL-5<br />
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[[3qt2]] - hIL-5 + IL-5 receptor α (mutant) <BR />
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**[[3qt2]] - hIL-5 + IL-5 receptor α (mutant) <BR />
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[[3va2]] - hIL-5 + IL-5 receptor α <BR />
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**[[3va2]] - hIL-5 + IL-5 receptor α <BR />
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===IL-6===
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*IL-6
-
[[1alu]] – hIL-6<BR />
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**[[1alu]] – hIL-6<BR />
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[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
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**[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
-
[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
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**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
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[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
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**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
-
[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8<br />
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**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8<br />
-
[[4j4l]] – hIL-6 + internalin B<BR />
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**[[4j4l]] – hIL-6 + internalin B<BR />
-
[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
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**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
-
===IL-7===
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*IL-7
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[[3di2]], [[3di3]] - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
+
**[[3di2]], [[3di3]] - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
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===IL-8===
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*IL-8
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[[3il8]] – hIL-8<BR />
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**[[3il8]] – hIL-8<BR />
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[[1il8]], [[2il8]] – hIL-8]- NMR<BR />
+
**[[1il8]], [[2il8]] – hIL-8]- NMR<BR />
-
[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
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**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
-
[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
+
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
-
[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
+
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
-
[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
+
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
-
===IL-10===
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*IL-10
-
[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
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**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
-
[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
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**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
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[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
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**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
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===IL-10 viral===
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*IL-10 viral
-
[[1vlk]] - hvIL-10 residues 26-170 - human herpesvirus 4<BR />
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**[[1vlk]] - hvIL-10 residues 26-170 - human herpesvirus 4<BR />
-
[[1y6m]] - hvIL-10 residues 26-170 + IL-10 receptor α <BR />
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**[[1y6m]] - hvIL-10 residues 26-170 + IL-10 receptor α <BR />
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[[1y6n]] - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α <BR />
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**[[1y6n]] - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α <BR />
-
[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
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**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
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[[1lk3]] - hvIL-10 residues 26-175 + antibody
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**[[1lk3]] - hvIL-10 residues 26-175 + antibody
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===IL-12===
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*IL-12
-
[[1f45]] - hIL-12 α and β (mutant) <BR />
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**[[1f45]] - hIL-12 α and β (mutant) <BR />
-
[[1f42]] - hIL-12 β P40 domain<BR />
+
**[[1f42]] - hIL-12 β P40 domain<BR />
-
[[3hmx]] - hIL-12 α and β+ antibody<br />
+
**[[3hmx]] - hIL-12 α and β+ antibody<br />
-
[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
+
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
-
===IL-13===
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*IL-13
-
[[1ijz]], [[1ik0]] – hIL-13 – NMR<BR />
+
**[[1ijz]], [[1ik0]] – hIL-13 – NMR<BR />
-
[[1ga3]] - hIL-13 residues 21-132 - NMR<BR />
+
**[[1ga3]] - hIL-13 residues 21-132 - NMR<BR />
-
[[3l5w]], [[3l5x]], [[3l5y]], [[3g6d]], [[4i77]], [[4ps4]] - hIL-13 residues 35-146 + antibody<BR />
+
**[[3l5w]], [[3l5x]], [[3l5y]], [[3g6d]], [[4i77]], [[4ps4]] - hIL-13 residues 35-146 + antibody<BR />
-
[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
+
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
-
[[3bpo]] - hIL-13 + IL-4 receptor α + IL-13 receptor α
+
**[[3bpo]] - hIL-13 + IL-4 receptor α + IL-13 receptor α
-
===IL-15===
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*IL-15
-
[[2xqb]] – hIL-15 + antibody<BR />
+
**[[2xqb]] – hIL-15 + antibody<BR />
-
[[2psm]], [[2z3q]], [[2z3r]] - hIL-15 + IL-15 receptor α<br />
+
**[[2psm]], [[2z3q]], [[2z3r]] - hIL-15 + IL-15 receptor α<br />
-
[[4gs7]] - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ <br />
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**[[4gs7]] - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ <br />
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===IL-16===
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*IL-16
-
[[1i16]] – hIL-16 - NMR<BR />
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**[[1i16]] – hIL-16 - NMR<BR />
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[[1x6d]] – hIL-16 PDZ domain – NMR<BR />
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**[[1x6d]] – hIL-16 PDZ domain – NMR<BR />
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===IL-17===
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*IL-17
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[[4hr9]] - hIL-17A (mutant)<br />
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**[[4hr9]] - hIL-17A (mutant)<br />
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[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
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**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
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[[2vxs]] - hIL-17A residues 20-255 + antibody<BR />
+
**[[2vxs]] - hIL-17A residues 20-255 + antibody<BR />
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[[1jpy]] – hIL-17F<BR />
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**[[1jpy]] – hIL-17F<BR />
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[[3jvf]] - hIL-17F + IL-17 receptor α
+
**[[3jvf]] - hIL-17F + IL-17 receptor α
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===IL-18 (Interferon-γ inducing factor)===
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*IL-18 (Interferon-γ inducing factor)
-
[[1j0s]] – hIL-18 - NMR<BR />
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**[[1j0s]] – hIL-18 - NMR<BR />
-
[[4hjj]] - hIL-18 + antibody<br />
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**[[4hjj]] - hIL-18 + antibody<br />
-
[[2vxt]] - hIL-18 (mutant) + antibody<BR />
+
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
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[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
+
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
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[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein
+
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein
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===IL-19===
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*IL-19
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[[1n1f]] – hIL-19
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**[[1n1f]] – hIL-19
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===IL-20===
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*IL-20
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[[4doh]] - hIL-20 + IL-20 receptor α,β <BR />
+
**[[4doh]] - hIL-20 + IL-20 receptor α,β <BR />
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===IL-21===
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*IL-21
-
[[2oqp]]– hIL-21 – NMR<BR />
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**[[2oqp]]– hIL-21 – NMR<BR />
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[[3tgx]] - hIL-21 + IL-21 receptor α (mutant) <BR />
+
**[[3tgx]] - hIL-21 + IL-21 receptor α (mutant) <BR />
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===IL-22===
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*IL-22
-
[[1ykb]], [[1m4r]] – hIL-22<BR />
+
**[[1ykb]], [[1m4r]] – hIL-22<BR />
-
[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
+
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
-
[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
+
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
-
[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody
+
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody
-
===IL-23===
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*IL-23
-
[[3d87]] - hIL-23 α<BR />
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**[[3d87]] - hIL-23 α<BR />
-
[[3d85]] - hIL-23 α + antibody<BR />
+
**[[3d85]] - hIL-23 α + antibody<BR />
-
[[4grw]] - hIL-23 α + + hIL-12 β + nanobody<BR />
+
**[[4grw]] - hIL-23 α + + hIL-12 β + nanobody<BR />
-
[[3duh]] - hIL-23 α + hIL-12 β
+
**[[3duh]] - hIL-23 α + hIL-12 β
-
===IL-28===
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*IL-28
-
[[3hhc]] – hIL-28B
+
**[[3hhc]] – hIL-28B
-
===IL-29===
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*IL-29
-
[[3og4]], [[3og6]] – hIL-29 + IL-28 receptor α
+
**[[3og4]], [[3og6]] – hIL-29 + IL-28 receptor α
 +
*IL-33
-
===IL-33===
+
**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
-
[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
+
*IL-34
-
===IL-34===
+
**[[4dkc]] - hIL-34<br />
-
 
+
**[[4exn]] - mIL-34<br />
-
[[4dkc]] - hIL-34<br />
+
**[[4dkd]] - hIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
-
[[4exn]] - mIL-34<br />
+
**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
-
[[4dkd]] - hIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
+
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody
-
[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
+
}}
-
[[4dke]], [[4dkf]] - hIL-34 active core + antibody
+
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Revision as of 12:11, 27 November 2014

Template:STRUCTURE 2nvh

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.

  • IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
  • IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
  • IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
  • IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-5 stimulates B cell growth and increases immunoglobulin secretion.
  • IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
  • IL-7 is a cytokine important for B and T cells development.
  • IL-8 induces chemotaxis and phagocytosis.
  • IL-10 see Interleukin-10.
  • IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
  • IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-15 see Interleukin-15.
  • IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
  • IL-17 recruits monocytes and neutrophils to the site of inflammation.
  • IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
  • IL-19 induces activation of the signal transducer and activator of STAT3.
  • IL-21 has potent effect on natural killer cells.
  • IL-22 stimulates inflammatory responses like S100 and defensin.
  • IL-23 induces activation of the signal transducer and activator of STAT4.
  • IL-28 has a role in the immune defense against viruses.
  • IL-29 similar to IL-28.
  • IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
  • IL-34 increases growth or survival of monocytes.

3D structures of interleukin

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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