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Neuraminidase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Neuraminidase===
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*'''Neuraminidase'''
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[[2ya4]], [[2w20]], [[2vvz]] – SpNANA catalytic domain – ''Streptococcus pneumoniae''<br />
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**[[2ya4]], [[2w20]], [[2vvz]] – SpNANA catalytic domain – ''Streptococcus pneumoniae''<br />
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[[3h71]] - SpNANA catalytic domain precursor<br />
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**[[3h71]] - SpNANA catalytic domain precursor<br />
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[[2vw0]], [[2vw1]], [[2vw2]] - SpNANB<br />
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**[[2vw0]], [[2vw1]], [[2vw2]] - SpNANB<br />
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[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – NANA – ''Aspergillus fumigatus''<br />
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**[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – NANA – ''Aspergillus fumigatus''<br />
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[[2w68]] – VcNANA sialic acid binding domain – ''Vibrio cholerae''<br />
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**[[2w68]] – VcNANA sialic acid binding domain – ''Vibrio cholerae''<br />
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[[1w0o]], [[1kit]]– VcNANA<br />
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**[[1w0o]], [[1kit]]– VcNANA<br />
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[[1snt]], [[1so7]] – hNeu2 - human<br />
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**[[1snt]], [[1so7]] – hNeu2 - human<br />
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[[2f24]], [[2f26]], [[2f28]] – hNeu2 (mutant) <br />
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**[[2f24]], [[2f26]], [[2f28]] – hNeu2 (mutant) <br />
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[[1eur]] - MvNANA residues 43-407 – ''Micromonospora viridifaciens''<br />
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**[[1eur]] - MvNANA residues 43-407 – ''Micromonospora viridifaciens''<br />
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[[1euu]] - MvNANA residues 47-647<br />
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**[[1euu]] - MvNANA residues 47-647<br />
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[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
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**[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
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[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium''<br />
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**[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium''<br />
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[[4bbw]] – NAN – ''Bacterioides thetaiotaomicron''<br />
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**[[4bbw]] – NAN – ''Bacterioides thetaiotaomicron''<br />
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''Binary complexes of Neuraminidase''
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*Binary complexes of Neuraminidase
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[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
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**[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
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[[3h73]] - SpNANA catalytic domain precursor + sialic acid analog<br />
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**[[3h73]] - SpNANA catalytic domain precursor + sialic acid analog<br />
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[[2ya5]] - SpNANA catalytic domain + sialic acid<br />
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**[[2ya5]] - SpNANA catalytic domain + sialic acid<br />
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[[2ya7]], [[2ya8]] - SpNANA catalytic domain + inhibitor<br />
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**[[2ya7]], [[2ya8]] - SpNANA catalytic domain + inhibitor<br />
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[[2ya6]] - SpNANA catalytic domain + sialic acid analog<br />
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**[[2ya6]] - SpNANA catalytic domain + sialic acid analog<br />
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[[2jkb]] - SpNANB residues 30-697 + sialic acid analog<br />
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**[[2jkb]] - SpNANB residues 30-697 + sialic acid analog<br />
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[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpNANB + inhibitor<br />
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**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpNANB + inhibitor<br />
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[[1w0p]] – VcNANA + sialic derivative<br />
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**[[1w0p]] – VcNANA + sialic derivative<br />
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[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor<br />
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**[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor<br />
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[[2f25]], [[2f27]], [[2f29]], [[4nc5]], [[4ncs]] - hNeu2 (mutant) + sialic acid analog<br />
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**[[2f25]], [[2f27]], [[2f29]], [[4nc5]], [[4ncs]] - hNeu2 (mutant) + sialic acid analog<br />
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[[1vcu]] - hNeu2 + sialic acid analog<br />
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**[[1vcu]] - hNeu2 + sialic acid analog<br />
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[[1eus]] - MvNANA residues 43-407 + neuraminic acid derivative<br />
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**[[1eus]] - MvNANA residues 43-407 + neuraminic acid derivative<br />
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[[2bzd]] - MvNANA residues 47-647 (mutant) + galactose<br />
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**[[2bzd]] - MvNANA residues 47-647 (mutant) + galactose<br />
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[[1eut]] - MvNANA residues 47-647 + galactose<br />
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**[[1eut]] - MvNANA residues 47-647 + galactose<br />
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[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
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**[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
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[[1dil]], [[1dim]] – StNANA + inhibitor<br />
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**[[1dil]], [[1dim]] – StNANA + inhibitor<br />
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[[2sim]], [[2sil]] - StNANA + neuraminic acid derivative<br />
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**[[2sim]], [[2sil]] - StNANA + neuraminic acid derivative<br />
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===Influenza virus neuraminidase===
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*'''Influenza virus neuraminidase'''
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[[3nss]], [[3k36]], [[3beq]], [[3cye]], [[2cml]], [[2b8h]], [[2ht5]], [[1v0z]], [[1nn2]], [[4hzv]] – IvNANA residues 82-469 – Influenza virus<br />
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**[[3nss]], [[3k36]], [[3beq]], [[3cye]], [[2cml]], [[2b8h]], [[2ht5]], [[1v0z]], [[1nn2]], [[4hzv]] – IvNANA residues 82-469 – Influenza virus<br />
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[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
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**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
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[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
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**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
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[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
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**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
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[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
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**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
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[[2ht5]] – IvNAN N8 residues 82-469<br />
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**[[2ht5]] – IvNAN N8 residues 82-469<br />
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[[2htv]] - IvNAN N4 residues 82-469<br />
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**[[2htv]] - IvNAN N4 residues 82-469<br />
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[[3sal]] - IvNAN N5 residues 82-469<br />
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**[[3sal]] - IvNAN N5 residues 82-469<br />
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[[2hty]] - IvNAN N1 residues 82-469<br />
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**[[2hty]] - IvNAN N1 residues 82-469<br />
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[[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] - IvNAN N9 residues 82-469<br />
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**[[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] - IvNAN N9 residues 82-469<br />
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[[7nn9]] - IvNAN N9 Tern<br />
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**[[7nn9]] - IvNAN N9 Tern<br />
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[[2qwa]] - IvNAN N9 Tern (mutant)<br />
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**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
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[[4gdi]], [[4gdj]] - IvNAN N10<br />
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**[[4gdi]], [[4gdj]] - IvNAN N10<br />
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[[4b7m]] - IvNAN H1n1
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**[[4b7m]] - IvNAN H1n1
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''Binary complexes of Influenza virus neuraminidase''
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*Binary complexes of Influenza virus neuraminidase
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[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />
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**[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />
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[[3k37]], [[3b7e]], [[1vcj]], [[1l7f]], [[1f8c]], [[1f8d]], [[1f8e]], [[1a4g]], [[1a4q]], [[1b9t]], [[1b9v]], [[1b9s]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]], [[4d8s]], [[4ks1]], [[4ks2]], [[4ks3]], [[4ks4]], [[4ks5]], [[4m3m]], [[4mju]], [[4mjv]] – IvNANA + inhibitor<br />
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**[[3k37]], [[3b7e]], [[1vcj]], [[1l7f]], [[1f8c]], [[1f8d]], [[1f8e]], [[1a4g]], [[1a4q]], [[1b9t]], [[1b9v]], [[1b9s]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]], [[4d8s]], [[4ks1]], [[4ks2]], [[4ks3]], [[4ks4]], [[4ks5]], [[4m3m]], [[4mju]], [[4mjv]] – IvNANA + inhibitor<br />
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[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]] – IvNAN H1n1 + inhibitor<br />
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**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]] – IvNAN H1n1 + inhibitor<br />
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[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]] - IvNAN H1n1 + drug<br />
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**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]] - IvNAN H1n1 + drug<br />
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[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
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**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
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[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
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**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
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[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN N8 + inhibitor<br />
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**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN N8 + inhibitor<br />
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[[2htr]] – IvNAN N8 + sialic acid analog<br />
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**[[2htr]] – IvNAN N8 + sialic acid analog<br />
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[[3san]], [[3ti8]] - IvNAN N5 + flu drug<br />
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**[[3san]], [[3ti8]] - IvNAN N5 + flu drug<br />
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[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
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**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
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[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
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**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
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[[2htw]] - IvNAN N4 + sialic acid analog<br />
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**[[2htw]] - IvNAN N4 + sialic acid analog<br />
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[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN N2 + sialic acid<br />
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**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN N2 + sialic acid<br />
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[[4gzp]], [[4gzt]] - IvNAN N2 + drug<br />
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**[[4gzp]], [[4gzt]] - IvNAN N2 + drug<br />
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[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
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**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
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[[1nna]], [[1nnb]] - IvNAN N9 + neuraminic acid derivative<br />
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**[[1nna]], [[1nnb]] - IvNAN N9 + neuraminic acid derivative<br />
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[[4dgr]] - IvNAN N9 + benzoic acid derivative<br />
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**[[4dgr]] - IvNAN N9 + benzoic acid derivative<br />
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[[1xoe]], [[1xog]], [[3w09]] - IvNAN N9 Tern + inhibitor<br />
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**[[1xoe]], [[1xog]], [[3w09]] - IvNAN N9 Tern + inhibitor<br />
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[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN N9 + flu drug<br />
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**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN N9 + flu drug<br />
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[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
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**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
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[[2qwc]], [[2qwd]], [[2qwe]] - IvNAN N9 Tern (mutant) + sialic acid analog<br />
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**[[2qwc]], [[2qwd]], [[2qwe]] - IvNAN N9 Tern (mutant) + sialic acid analog<br />
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[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
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**[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
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[[1bji]], [[1nnc]] - IvNAN N9 Tern + sialic acid analog<br />
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**[[1bji]], [[1nnc]] - IvNAN N9 Tern + sialic acid analog<br />
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[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
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**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
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[[1nma]], [[1nmb]], [[1a14]] [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
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**[[1nma]], [[1nmb]], [[1a14]] [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
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[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
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**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
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===Endo-neuraminidase===
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*'''Endo-neuraminidase'''
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[[3gvf]], [[3gvk]], [[3gvj]] – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F<br />
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**[[3gvf]], [[3gvk]], [[3gvj]] – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F<br />
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[[3gvl]], [[3ju4]] – ENANA residues 246-910<br />
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**[[3gvl]], [[3ju4]] – ENANA residues 246-910<br />
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[[3gw6]] – ENANA residues 790-1064<br />
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**[[3gw6]] – ENANA residues 790-1064<br />
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===Pseudaminidase===
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*'''Pseudaminidase'''
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[[2w38]], [[3h6j]] – PNANA – ''Pseudomonas aeruginosa''
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**[[2w38]], [[3h6j]] – PNANA – ''Pseudomonas aeruginosa''
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===Trans-sialidase===
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*'''Trans-sialidase'''
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[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech
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**[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:25, 1 December 2014

Template:STRUCTURE 3nss

Neuraminidase (NAN) cleaves the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza. See also

For other inhibitors see Neuraminidase Inhibitor Pharmacokinetics.

3D structures of Neuraminidase

Updated on 01-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

Retrieved from "http://52.214.119.220/wiki/index.php/Neuraminidase"
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