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Pantothenate kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PanK I===
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*'''PanK I'''
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[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
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**[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
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[[1esn]] - EcPanK + ANP<br />
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**[[1esn]] - EcPanK + ANP<br />
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[[1sq5]] - EcPanK + ADP + PAU<br />
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**[[1sq5]] - EcPanK + ADP + PAU<br />
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[[3tqc]] - PanK – ''Coxiella burnetii''
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**[[3tqc]] - PanK – ''Coxiella burnetii''
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''PanK I binary complex''
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*PanK I binary complex
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[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
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**[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
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[[2zs8]], [[2zsb]] - MtPanK + ADP<br />
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**[[2zs8]], [[2zsb]] - MtPanK + ADP<br />
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[[3af1]] - MtPanK + GDP <br />
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**[[3af1]] - MtPanK + GDP <br />
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[[3af2]] - MtPanK + AMPPCP<br />
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**[[3af2]] - MtPanK + AMPPCP<br />
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[[3af4]] - MtPanK + GMPPCP<br />
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**[[3af4]] - MtPanK + GMPPCP<br />
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[[2zsd]] - MtPanK + CoA<br />
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**[[2zsd]] - MtPanK + CoA<br />
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[[3avo]] - MtPanK + PAU<br />
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**[[3avo]] - MtPanK + PAU<br />
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[[3avp]], [[3avq]] - MtPanK + PAU derivative<br />
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**[[3avp]], [[3avq]] - MtPanK + PAU derivative<br />
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[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br />
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**[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br />
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[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br />
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**[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br />
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''PanK I ternary complex''
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*PanK I ternary complex
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[[2zs9]] - MtPanK + ADP + PAU<br />
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**[[2zs9]] - MtPanK + ADP + PAU<br />
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[[2zse]] - MtPanK + AMPPCP + PAU<br />
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**[[2zse]] - MtPanK + AMPPCP + PAU<br />
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[[3af3]] - MtPanK + GMPPCP + PAU<br />
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**[[3af3]] - MtPanK + GMPPCP + PAU<br />
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[[2zsf]] - MtPanK + ADP + ATP<br />
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**[[2zsf]] - MtPanK + ADP + ATP<br />
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[[2zsa]] - MtPanK + ADP + PPT<BR />
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**[[2zsa]] - MtPanK + ADP + PPT<BR />
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[[3aez]] - MtPanK + GDP + PPT<BR />
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**[[3aez]] - MtPanK + GDP + PPT<BR />
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[[3af0]] - MtPanK + GDP + PAU<br />
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**[[3af0]] - MtPanK + GDP + PAU<br />
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[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br />
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**[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br />
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[[4gi7]] – KpPanK + ADP + pantothenate analog<br />
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**[[4gi7]] – KpPanK + ADP + pantothenate analog<br />
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===PanK II===
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*'''PanK II'''
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[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br />
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**[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br />
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[[4nb4]] - SaPanK + ADP + pantothenamide<br />
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**[[4nb4]] - SaPanK + ADP + pantothenamide<br />
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===PanK III===
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*'''PanK III'''
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[[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
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**[[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
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[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
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**[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
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[[2h3g]] - PanK – ''Bacillus anthracis''<br />
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**[[2h3g]] - PanK – ''Bacillus anthracis''<br />
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[[3djc]] - PanK – ''Legionella pneumophila''<br />
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**[[3djc]] - PanK – ''Legionella pneumophila''<br />
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[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br />
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**[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br />
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''PanK III binary complex''
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*PanK III binary complex
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[[2f9w]] - PaPanK + PAU<br />
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**[[2f9w]] - PaPanK + PAU<br />
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[[3bex]] - TmPanK + PAU<br />
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**[[3bex]] - TmPanK + PAU<br />
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[[3bf3]] - TmPanK + PPT<BR />
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**[[3bf3]] - TmPanK + PPT<BR />
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''PanK III ternary complex''
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*PanK III ternary complex
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[[3bf1]] - TmPanK + ADP + PAU<br />
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**[[3bf1]] - TmPanK + ADP + PAU<br />
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[[4o5f]] - BtPanK + ADP + PAU <br />
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**[[4o5f]] - BtPanK + ADP + PAU <br />
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===Human PanK===
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*'''Human PanK'''
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[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
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[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
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[[3sms]] – hPanK 3 + PAU analog
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**[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
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**[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
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**[[3sms]] – hPanK 3 + PAU analog
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:41, 2 December 2014

Template:STRUCTURE 2f9w

Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.

3D structures of pantothenate kinase

Updated on 02-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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