Penicillin-binding protein

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PBP===
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*'''Penicillin-binding protein'''
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[[1qme]], [[1rp5]], [[2z2l]] – SpPBP 2X – ''Streptococcus pneumoniae''<br />
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**[[1qme]], [[1rp5]], [[2z2l]] – SpPBP 2X – ''Streptococcus pneumoniae''<br />
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[[1k25]], [[1pyy]] – SpPBP 2X (mutant) <br />
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**[[1k25]], [[1pyy]] – SpPBP 2X (mutant) <br />
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[[2fff]] - SpPBP 1B<br />
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**[[2fff]] - SpPBP 1B<br />
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[[2bg1]], [[2xd5]] - SpPBP 1B (mutant) <br />
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**[[2bg1]], [[2xd5]] - SpPBP 1B (mutant) <br />
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[[2c6w]], [[2v2f]] - SpPBP 1A <br />
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**[[2c6w]], [[2v2f]] - SpPBP 1A <br />
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[[2wad]], [[2wae]], [[2waf]] – SpPBP 2B<br />
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**[[2wad]], [[2wae]], [[2waf]] – SpPBP 2B<br />
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[[1hd8]], [[1nj4]], [[1sdn]] – EcPBP 5 (mutant) – ''Escherichia coli''<br />
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**[[1hd8]], [[1nj4]], [[1sdn]] – EcPBP 5 (mutant) – ''Escherichia coli''<br />
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[[2ex2]] – EcPBP 4<br />
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**[[2ex2]] – EcPBP 4<br />
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[[1nzo]], [[1nzu]] – EcPBP 5<br />
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**[[1nzo]], [[1nzu]] – EcPBP 5<br />
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[[3it9]] – EcPBP 6<br />
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**[[3it9]] – EcPBP 6<br />
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[[3vma]] – EcPBP 1B<br />
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**[[3vma]] – EcPBP 1B<br />
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[[1mwr]], [[1vqq]] - SaPBP 2A (mutant) – ''Staphylococcus aureus''<br />
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**[[1mwr]], [[1vqq]] - SaPBP 2A (mutant) – ''Staphylococcus aureus''<br />
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[[2olu]], [[3dwk]] – SaPBP 2<br />
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**[[2olu]], [[3dwk]] – SaPBP 2<br />
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[[3vsk]] - SaPBP 3<br />
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**[[3vsk]] - SaPBP 3<br />
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[[1tvf]] – SaPBP 4<br />
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**[[1tvf]] – SaPBP 4<br />
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[[1w5d]] – BsPBP 4A – ''Bacillus subtilis''<br />
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**[[1w5d]] – BsPBP 4A – ''Bacillus subtilis''<br />
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[[3mfd]] – BsPBP 5*<br />
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**[[3mfd]] – BsPBP 5*<br />
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[[2oqo]] – AaPBP 1A – ''Aquifex aeolicus''<br />
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**[[2oqo]] – AaPBP 1A – ''Aquifex aeolicus''<br />
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[[3equ]] – NgPBP 2 – ''Neisseria gonorrhoeae''<br />
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**[[3equ]] – NgPBP 2 – ''Neisseria gonorrhoeae''<br />
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[[3eqv]] – NgPBP 2 (mutant) <br />
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**[[3eqv]] – NgPBP 2 (mutant) <br />
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[[3a3d]] – HiPBP 4 – ''Haemophilus influenza''<br />
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**[[3a3d]] – HiPBP 4 – ''Haemophilus influenza''<br />
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[[3a3j]] – HiPBP 5<br />
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**[[3a3j]] – HiPBP 5<br />
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[[3lo7]], [[3un7]] – MtPBP A – ''Mycobacterium tuberculosis''<br />
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**[[3lo7]], [[3un7]] – MtPBP A – ''Mycobacterium tuberculosis''<br />
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[[3oc2]], [[3pbn]] – PaPBP 3 – ''Pseudomonas aeruginosa''<br />
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**[[3oc2]], [[3pbn]] – PaPBP 3 – ''Pseudomonas aeruginosa''<br />
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[[3tg9]] – PBP – ''Bacillus halodurans''<br />
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**[[3tg9]] – PBP – ''Bacillus halodurans''<br />
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[[3udf]] – AbPBP – ''Acinetobacter baumannii''<br />
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**[[3udf]] – AbPBP – ''Acinetobacter baumannii''<br />
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[[3zg7]] – LmPBP 4 – ''Listeria monocytogenes''<br />
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**[[3zg7]] – LmPBP 4 – ''Listeria monocytogenes''<br />
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===PBP complex with antibiotics===
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*Penicillin-binding protein complex with antibiotics
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[[1qmf]], [[2z2m]], [[2zc3]], [[2zc4]], [[2zc5]], [[2zc6]] – SpPBP 2X + antibiotic<br />
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**[[1qmf]], [[2z2m]], [[2zc3]], [[2zc4]], [[2zc5]], [[2zc6]] – SpPBP 2X + antibiotic<br />
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[[1mwu]], [[1mwt]], [[1mws]] - SaPBP 2A (mutant) + antibiotic<br />
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**[[1mwu]], [[1mwt]], [[1mws]] - SaPBP 2A (mutant) + antibiotic<br />
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[[2uwx]] - SaPBP 1B (mutant) + antibiotic<br />
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**[[2uwx]] - SaPBP 1B (mutant) + antibiotic<br />
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[[2olv]] - SaPBP 2 + antibiotic<br />
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**[[2olv]] - SaPBP 2 + antibiotic<br />
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[[3zfz]], [[3zg0]], [[4dki]] - SaPBP 2’ + antibiotic<br />
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**[[3zfz]], [[3zg0]], [[4dki]] - SaPBP 2’ + antibiotic<br />
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[[3vsl]] - SaPBP 3 + antibiotic<br />
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**[[3vsl]] - SaPBP 3 + antibiotic<br />
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[[3hum]], [[3hun]] - SaPBP 4 (mutant) + antibiotic<br />
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**[[3hum]], [[3hun]] - SaPBP 4 (mutant) + antibiotic<br />
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[[2c5w]] - SpPBP 1A + antibiotic<br />
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**[[2c5w]] - SpPBP 1A + antibiotic<br />
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[[2jch]], [[2je5]], [[2xd1]] - SpPBP 1B (mutant) + antibiotic<br />
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**[[2jch]], [[2je5]], [[2xd1]] - SpPBP 1B (mutant) + antibiotic<br />
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[[2ex6]], [[2ex8]], [[2ex9]], [[2exa]], [[2exb]] - EcPBP 4 + antibiotic<br />
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**[[2ex6]], [[2ex8]], [[2ex9]], [[2exa]], [[2exb]] - EcPBP 4 + antibiotic<br />
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[[3beb]], [[3bec]], [[3mzd]], [[3mze]], [[3mzf]] - EcPBP 5 + antibiotic<br />
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**[[3beb]], [[3bec]], [[3mzd]], [[3mze]], [[3mzf]] - EcPBP 5 + antibiotic<br />
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[[3ita]] - EcPBP 6 + antibiotic<br />
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**[[3ita]] - EcPBP 6 + antibiotic<br />
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[[3fwl]], [[3fwm]] – EcPBP 1B + antibiotic<br />
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**[[3fwl]], [[3fwm]] – EcPBP 1B + antibiotic<br />
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[[3a3e]], [[3a3f]], [[3a3i]] – HiPBP 4 + antibiotic<br />
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**[[3a3e]], [[3a3f]], [[3a3i]] – HiPBP 4 + antibiotic<br />
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[[3ocl]], [[3ocn]], [[3pbo]], [[3pbq]], [[3pbr]], [[3pbs]], [[3pbt]], [[4kqo]], [[4kqq]], [[4kqr]], [[4l0l]] – PaPBP 3 + antibiotic<br />
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**[[3ocl]], [[3ocn]], [[3pbo]], [[3pbq]], [[3pbr]], [[3pbs]], [[3pbt]], [[4kqo]], [[4kqq]], [[4kqr]], [[4l0l]] – PaPBP 3 + antibiotic<br />
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[[3nb6]], [[3nb7]] - AaPBP 1A + antibiotic<br />
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**[[3nb6]], [[3nb7]] - AaPBP 1A + antibiotic<br />
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[[3udi]], [[3udx]], [[3ue0]], [[3ue1]] - AbPBP + antibiotic<br />
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**[[3udi]], [[3udx]], [[3ue0]], [[3ue1]] - AbPBP + antibiotic<br />
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===PBP complex with boronic acid derivatives===
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*Penicillin-binding protein complex with boronic acid derivatives
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[[1z6f]] – EcPBP 5 + boronic acid<br />
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**[[1z6f]] – EcPBP 5 + boronic acid<br />
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[[2y2g]], [[2y2h]], [[2y2i]], [[2y2j]], [[2y2k]], [[2y2l]], [[2y2m]], [[2y2n]], [[2y2o]], [[2y2p]], [[2y2q]] - SpPBP 1B + boronic acid derivative
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**[[2y2g]], [[2y2h]], [[2y2i]], [[2y2j]], [[2y2k]], [[2y2l]], [[2y2m]], [[2y2n]], [[2y2o]], [[2y2p]], [[2y2q]] - SpPBP 1B + boronic acid derivative
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===PBP complex with peptidoglycan===
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*Penicillin-binding protein complex with peptidoglycan
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[[3itb]] - EcPBP 6 + peptidoglycan peptide<br />
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**[[3itb]] - EcPBP 6 + peptidoglycan peptide<br />
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[[2j9p]] - BsPBP 4A + peptidoglycan peptide<br />
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**[[2j9p]] - BsPBP 4A + peptidoglycan peptide<br />
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[[3zg5]] - SaPBP + peptidoglycan analog<br />
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**[[3zg5]] - SaPBP + peptidoglycan analog<br />
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===PBP complex with other inhibitors===
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*Penicillin-binding protein complex with other inhibitors
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[[4fsf]] – PaPBP + inhibitor<br />
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**[[4fsf]] – PaPBP + inhibitor<br />
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===D-alanyl-D-alanine carboxypeptidase===
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*'''D-alanyl-D-alanine carboxypeptidase'''
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[[1w79]], [[1w8q]] – AcDDP – ''Actinomadura''<br />
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[[3pte]], [[1skf]] – StDDP – ''Streptomyces''<br />
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[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StDDP (mutant) <br />
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[[1lbu]] – DDP + Zn – ''Streptomyces albus''<br />
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[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcDDP + antibiotic<br />
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[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], [[1pwg]] – StDDP + antibiotic<br />
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[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]] – AcDDP + boronic acid derivative<br />
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[[1ikg]], [[1iki]] – StDDP + peptidoglycan fragment<br />
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[[1mpl]] - StDDP + phosphonate inhibitor<br />
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[[1scw]], [[1sde]] - StDDP + cyclic phosphate inhibitor<br />
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[[1yqs]] - StDDP + sultam inhibitor<br />
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[[3zcz]] – AcDDP + inhibitor<br />
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**[[1w79]], [[1w8q]] – AcDDP – ''Actinomadura''<br />
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**[[3pte]], [[1skf]] – StDDP – ''Streptomyces''<br />
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**[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StDDP (mutant) <br />
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**[[1lbu]] – DDP + Zn – ''Streptomyces albus''<br />
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**[[2wke]], [[1w8y]], [[2vgj]], [[2vgk]], [[4ben]] - AcDDP + antibiotic<br />
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**[[1cef]], [[1ceg]], [[1hvb]], [[1pw1]], [[1pw8]], [[1pwc]], [[1pwd]], [[1pwg]] – StDDP + antibiotic<br />
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**[[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]] – AcDDP + boronic acid derivative<br />
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**[[1ikg]], [[1iki]] – StDDP + peptidoglycan fragment<br />
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**[[1mpl]] - StDDP + phosphonate inhibitor<br />
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**[[1scw]], [[1sde]] - StDDP + cyclic phosphate inhibitor<br />
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**[[1yqs]] - StDDP + sultam inhibitor<br />
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**[[3zcz]] – AcDDP + inhibitor<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:10, 2 December 2014

Template:STRUCTURE 2ex6

Penicillin-binding protein (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall. Their inhibition by antibiotics leads to irregularities in the cell wall and eventual bacterial death. The PBP are classified to high-molecular weight and low-molecular weight groups. D-alanyl-D-alanine carboxypeptidase (DDP) which cross-links peptidoglycan chains is also PBP.

3D structures of penicillin-binding protein

Updated on 02-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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