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Purine nucleoside phosphorylase

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'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. PNP deficiency results in severe combined immunodeficiency.
'''Purine nucleoside phosphorylase''' (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down. PNP deficiency results in severe combined immunodeficiency.
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</StructureSection>
==3D structures of purine nucleoside phosphorylase==
==3D structures of purine nucleoside phosphorylase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PNP===
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*'''Purine nucleoside phosphorylase'''
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[[1ula]], [[1m73]] – hPNP – human<br />
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**[[1ula]], [[1m73]] – hPNP – human<br />
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[[1pbn]] – bPNP – bovine<br />
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**[[1pbn]] – bPNP – bovine<br />
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[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
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**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br />
-
[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
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**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br />
-
[[1tcv]], [[1td1]] – SmPNP – ''Schistosoma masoni''<br />
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**[[1tcv]], [[1td1]] – SmPNP – ''Schistosoma masoni''<br />
-
[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
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**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br />
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[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
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**[[4mar]] – MrPNP – ''Meiothermus ruber''<br />
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[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]] – EcPNP – ''Escherichia coli'' <br />
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**[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]] – EcPNP – ''Escherichia coli'' <br />
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[[1otx]], [[1oum]], [[1ov6]], [[3opv]] – EcPNP (mutant)<br />
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**[[1otx]], [[1oum]], [[1ov6]], [[3opv]] – EcPNP (mutant)<br />
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[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />
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**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br />
-
[[1xe3]] – PNP – ''Bacillus anthracis''<br />
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**[[1xe3]] – PNP – ''Bacillus anthracis''<br />
-
[[4d8v]], [[4d8x]], [[4d8y]], [[4d98]] – BsPNP – ''Bacillus subtilis''<br />
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**[[4d8v]], [[4d8x]], [[4d8y]], [[4d98]] – BsPNP – ''Bacillus subtilis''<br />
-
[[3tl6]] – EhPNP – ''Entamoeba histolica''<br />
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**[[3tl6]] – EhPNP – ''Entamoeba histolica''<br />
-
[[3uav]] – BcPNP – ''Bacillus cereus''<br />
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**[[3uav]] – BcPNP – ''Bacillus cereus''<br />
-
[[4lkr]] – PNP – ''Shewanella oneidensis''<br />
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**[[4lkr]] – PNP – ''Shewanella oneidensis''<br />
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===PNP binary complex with phosphate===
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*Purine nucleoside phosphorylase binary complex with phosphate
-
[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
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**[[1a9o]], [[3pnp]], [[4pnp]] – bPNP + phosphate<br />
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[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
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**[[1qe5]] – CePNP + phosphate - ''Cellulomonas''<br />
-
[[1tcu]] – SmPNP + phosphate <br />
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**[[1tcu]] – SmPNP + phosphate <br />
-
[[3khs]] – PNP + phosphate – grouper iridovirus<br />
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**[[3khs]] – PNP + phosphate – grouper iridovirus<br />
-
[[4gka]] – hPNP (mutant) + phosphate<br />
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**[[4gka]] – hPNP (mutant) + phosphate<br />
-
[[4m3n]] – MrPNP + phosphate <br />
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**[[4m3n]] – MrPNP + phosphate <br />
-
[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
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**[[3ooe]], [[3ooh]] – EcPNP + phosphate <br />
-
[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
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**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br />
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===PNP complex with guanine and derivatives===
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*Purine nucleoside phosphorylase complex with guanine and guanine derivatives
-
[[1ulb]], [[1v2h]] – hPNP + guanine<br />
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**[[1ulb]], [[1v2h]] – hPNP + guanine<br />
-
[[4ece]] – hPNP (mutant) + guanine<br />
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**[[4ece]] – hPNP (mutant) + guanine<br />
-
[[1rfg]] – hPNP + guanosine<br />
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**[[1rfg]] – hPNP + guanosine<br />
-
[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
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**[[1yry]], [[3iny]] – hPNP + guanine derivative <br />
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[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
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**[[1v48]], [[2ai1]], [[2ai3]], [[3fuc]] – bPNP + guanine derivative <br />
-
[[3e9z]] – SmPNP + guanine derivative <br />
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**[[3e9z]] – SmPNP + guanine derivative <br />
-
[[3iex]] – SmPNP + guanosine<br />
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**[[3iex]] – SmPNP + guanosine<br />
-
[[1odj]] – TtPNP + guanosine<br />
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**[[1odj]] – TtPNP + guanosine<br />
-
[[4da0]], [[4da8]], [[4dae]] – BsPNP + guanosine derivative<br />
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**[[4da0]], [[4da8]], [[4dae]] – BsPNP + guanosine derivative<br />
-
[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />
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**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br />
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[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
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**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br />
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[[1b8n]] – bPNP + guanine derivative + phosphate<br />
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**[[1b8n]] – bPNP + guanine derivative + phosphate<br />
-
[[1c3x]] – CePNP + guanine derivative + phosphate<br />
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**[[1c3x]] – CePNP + guanine derivative + phosphate<br />
-
[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
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**[[1pwy]], [[1v41]], [[1v45]] – hPNP + antiviral drug <br />
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===PNP complex with inosine and derivatives===
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*Purine nucleoside phosphorylase complex with inosine and inosine derivatives
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[[1rct]] – hPNP + inosine <br />
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**[[1rct]] – hPNP + inosine <br />
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[[1a9q]], [[1a9s]] – bPNP + inosine <br />
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**[[1a9q]], [[1a9s]] – bPNP + inosine <br />
-
[[3faz]] – SmPNP + inosine <br />
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**[[3faz]] – SmPNP + inosine <br />
-
[[2ai2]] – bPNP + inosine derivative <br />
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**[[2ai2]] – bPNP + inosine derivative <br />
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[[1z38]] – TvPNP + inosine <br />
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**[[1z38]] – TvPNP + inosine <br />
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[[3uax]] – BcPNP + inosine <br />
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**[[3uax]] – BcPNP + inosine <br />
-
[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />
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**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br />
-
[[1z39]] – TvPNP + deoxyinosine <br />
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**[[1z39]] – TvPNP + deoxyinosine <br />
-
[[1a9t]], [[1a9p]] – bPNP + deazainosine + phosphate<br />
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**[[1a9t]], [[1a9p]] – bPNP + deazainosine + phosphate<br />
-
[[1pr0]] - EcPNP + inosine + phosphate<br />
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**[[1pr0]] - EcPNP + inosine + phosphate<br />
-
[[1v3q]] – hPNP + anti HIV drug <br />
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**[[1v3q]] – hPNP + anti HIV drug <br />
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===PNP complex with xanthine and derivatives===
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*Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives
-
[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
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**[[1pf7]], [[1rr6]], [[1rsz]], [[1rt9]], [[3k8o]], [[3k8q]] – hPNP + transition state analog <br />
-
[[2on6]] – hPNP (mutant) + transition state analog <br />
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**[[2on6]] – hPNP (mutant) + transition state analog <br />
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[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
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**[[1vfn]], [[1a9r]] – bPNP + hypoxanthine<br />
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[[3fnq]] – SmPNP + hypoxanthine<br />
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**[[3fnq]] – SmPNP + hypoxanthine<br />
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[[3scz]] – MtPNP + hypoxanthine<br />
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**[[3scz]] – MtPNP + hypoxanthine<br />
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[[4dab]] – BsPNP + hypoxanthine<br />
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**[[4dab]] – BsPNP + hypoxanthine<br />
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[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
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**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br />
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[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
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**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br />
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[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
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**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br />
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[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
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**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br />
-
[[3bgs]] – bPNP + transition state analog + phosphate<br />
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**[[3bgs]] – bPNP + transition state analog + phosphate<br />
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[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
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**[[2q7o]], [[3phb]] – hPNP + transition state analog + phosphate<br />
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[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
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**[[4ear]], [[4eb8]] – hPNP (mutant) + transition state analog + phosphate<br />
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[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
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**[[3mb8]] – PNP + transition state analog + phosphate – ''Toxoplasma gondii''<br />
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[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
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**[[1n3i]] – MtPNP + deazahypoxanthine + phosphate <br />
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[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
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**[[1i80]] – MtPNP + iminoribitol + deazahypoxanthine + phosphate <br />
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===PNP complex with adenine and derivatives===
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*Purine nucleoside phosphorylase complex with adenine and adenine derivatives
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[[1odi]] – TtPNP + adenosine <br />
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**[[1odi]] – TtPNP + adenosine <br />
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[[1z34]], [[1z35]] – TvPNP + adenosine derivative <br />
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**[[1z34]], [[1z35]] – TvPNP + adenosine derivative <br />
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[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
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**[[4ns1]] – PgPNP + adenosine derivative – ''Porphyromonas gingivalis''<br />
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[[4nsn]] – PgPNP + adenine <br />
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**[[4nsn]] – PgPNP + adenine <br />
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[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
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**[[3ggs]] – hPNP (mutant) + adenosine derivative <br />
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[[1z37]] – TvPNP + adenosine <br />
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**[[1z37]] – TvPNP + adenosine <br />
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[[3e9r]] – SmPNP + adenine <br />
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**[[3e9r]] – SmPNP + adenine <br />
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[[4dao]] – BsPNP + adenine <br />
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**[[4dao]] – BsPNP + adenine <br />
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[[3f8w]] – SmPNP + adenosine <br />
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**[[3f8w]] – SmPNP + adenosine <br />
-
[[1vhw]] – VcPNP + adenosine <br />
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**[[1vhw]] – VcPNP + adenosine <br />
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[[3u40]] – EhPNP + adenosine <br />
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**[[3u40]] – EhPNP + adenosine <br />
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[[4d9h]] – BsPNP + adenosine <br />
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**[[4d9h]] – BsPNP + adenosine <br />
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[[4dan]] – BsPNP + adenosine derivative<br />
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**[[4dan]] – BsPNP + adenosine derivative<br />
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[[2ac7]], [[3uaw]] – BcPNP + adenosine <br />
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**[[2ac7]], [[3uaw]] – BcPNP + adenosine <br />
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[[3uay]], [[3uaz]] – BcPNP (mutant) + adenosine <br />
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**[[3uay]], [[3uaz]] – BcPNP (mutant) + adenosine <br />
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[[4m1e]] – PNP + adenine – ''Planctomyces limnophilus''<br />
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**[[4m1e]] – PNP + adenine – ''Planctomyces limnophilus''<br />
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[[4lna]] – PNP + adenine + phosphate – ''Spirosoma linguale''<br />
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**[[4lna]] – PNP + adenine + phosphate – ''Spirosoma linguale''<br />
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[[1pk7]] - EcPNP + adenosine + phosphate<br />
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**[[1pk7]] - EcPNP + adenosine + phosphate<br />
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[[1pk9]], [[1pke]], [[1pr5]], [[1pr6]], [[1pw7]] - EcPNP + adenosine derivative + phosphate<br />
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**[[1pk9]], [[1pke]], [[1pr5]], [[1pr6]], [[1pw7]] - EcPNP + adenosine derivative + phosphate<br />
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===PNP complex with purine and derivatives===
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*Purine nucleoside phosphorylase complex with purine and purine derivatives
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[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
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**[[1lv8]], [[1lvu]], [[2qpl]] – bPNP + purine derivative <br />
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[[3gb9]] – hPNP (mutant) + purine derivative <br />
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**[[3gb9]] – hPNP (mutant) + purine derivative <br />
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[[1fxu]] – bPNP + purine derivative + phosphate<br />
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**[[1fxu]] – bPNP + purine derivative + phosphate<br />
-
[[1ovg]] - EcPNP (mutant) + purine derivative <br />
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**[[1ovg]] - EcPNP (mutant) + purine derivative <br />
-
[[1pr2]], [[1pr4]] – EcPNP + purine derivative + phosphate<br />
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**[[1pr2]], [[1pr4]] – EcPNP + purine derivative + phosphate<br />
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===Other PNP complexes===
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*Other purine nucleoside phosphorylase complexes
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+
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[[3d1v]] – hPNP + mercapto-quinazolinone<br />
+
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[[1z36]] – TvPNP + antibiotic<br />
+
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[[3djf]] – SmPNP + inhibitor<br />
+
-
[[3e0q]] – SmPNP + pyrimidine derivative<br />
+
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[[3fb1]] – SmPNP + ribose-1-phosphate <br />
+
-
[[1a69]], [[1pr1]] – EcPNP + formycin <br />
+
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[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
+
-
[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
+
-
[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
+
-
[[3occ]] – YpPNP + inhibitor + phosphate<br />
+
-
[[3of3]] – VcPNP + inhibitor + phosphate<br />
+
-
[[3phc]] – PfPNP + inhibitor + phosphate<br />
+
-
[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
+
 +
**[[3d1v]] – hPNP + mercapto-quinazolinone<br />
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**[[1z36]] – TvPNP + antibiotic<br />
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**[[3djf]] – SmPNP + inhibitor<br />
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**[[3e0q]] – SmPNP + pyrimidine derivative<br />
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**[[3fb1]] – SmPNP + ribose-1-phosphate <br />
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**[[1a69]], [[1pr1]] – EcPNP + formycin <br />
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**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br />
 +
**[[2i4t]], [[2isc]] – TvPNP + inhibitor + phosphate<br />
 +
**[[2p4s]] – PNP + inhibitor + phosphate – ''Anopheles gambiae''<br />
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**[[3occ]] – YpPNP + inhibitor + phosphate<br />
 +
**[[3of3]] – VcPNP + inhibitor + phosphate<br />
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**[[3phc]] – PfPNP + inhibitor + phosphate<br />
 +
**[[4da6]], [[4da7]], [[4dar]] – BsPNP + drug<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:44, 4 December 2014

Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

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3D structures of purine nucleoside phosphorylase

Updated on 04-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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