Response regulator

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Nitrate/nitrite RR===
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*Nitrate/nitrite response regulator
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[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
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**[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
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[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA
+
**[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA
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===Sporulation RR===
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*Sporulation response regulator
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[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
+
**[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
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[[1nat]] - BsSpo0F<br/ >
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**[[1nat]] - BsSpo0F<br/ >
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[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
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**[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
-
[[1ixm]] - BsSpo0B<br/ >
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**[[1ixm]] - BsSpo0B<br/ >
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[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
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**[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
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[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
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**[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
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===DNA-binding RR===
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*DNA-binding response regulator
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[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
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**[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
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[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
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**[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
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[[1p2f]] – TmDrrB<br/ >
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**[[1p2f]] – TmDrrB<br/ >
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[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
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**[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
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[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
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**[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
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[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
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**[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
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[[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
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**[[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ >
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[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
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**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
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[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
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**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
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[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
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**[[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ >
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[[2zxj]] - SaWalR DNA-binding domain<br/ >
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**[[2zxj]] - SaWalR DNA-binding domain<br/ >
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[[4gvp]] – SaVraR<br />
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**[[4gvp]] – SaVraR<br />
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[[4if4]] – SaVraR + Mg + BeF3<br />
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**[[4if4]] – SaVraR + Mg + BeF3<br />
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[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
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**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
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[[3q9v]] - DrRR C terminal<br />
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**[[3q9v]] - DrRR C terminal<br />
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[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />
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**[[3rjp]] - RR DNA -binding domain – ''Streptococcus pyogenes''<br />
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===Cyanobacterial phytochrome RR===
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*Cyanobacterial phytochrome response regulator
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[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
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**[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
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[[1jlk]] – SyRcp1 + Mn<br/ >
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**[[1jlk]] – SyRcp1 + Mn<br/ >
-
[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
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**[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
-
[[1k68]] – ToRcpB
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**[[1k68]] – ToRcpB
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===Phosphatase synthesis RR===
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*Phosphatase synthesis response regulator
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[[1mvo]] – BsPhoP receiver domain<br/ >
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**[[1mvo]] – BsPhoP receiver domain<br/ >
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[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
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**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
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[[2pmu]] – MtPhoP DNA-binding domain
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**[[2pmu]] – MtPhoP DNA-binding domain
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===Polar differentiation RR===
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*Polar differentiation response regulator
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[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
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**[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
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[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
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**[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
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===Photosynthetic apparatus RR===
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*Photosynthetic apparatus response regulator
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[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
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**[[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ >
-
[[1ys6]] – MtPrrA <br/ >
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**[[1ys6]] – MtPrrA <br/ >
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[[1ys7]] – MtPrrA + Mg
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**[[1ys7]] – MtPrrA + Mg
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===Redox RR===
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*Redox response regulator
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[[1xhe]] – EcArcA receiver domain <br/ >
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**[[1xhe]] – EcArcA receiver domain <br/ >
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[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
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**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
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[[2y79]] – MtDevs GAF domain (mutant)<br />
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**[[2y79]] – MtDevs GAF domain (mutant)<br />
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[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
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**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
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===Social motility RR===
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*Social motility response regulator
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[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
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**[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
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[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
+
**[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
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===Stalked-cell differentiation RR===
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*Stalked-cell differentiation response regulator
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[[2v0n]] – CvPleD + GMP + GTP<br/ >
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**[[2v0n]] – CvPleD + GMP + GTP<br/ >
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[[2wb4]], [[1w25]] - CvPleD + GMP
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**[[2wb4]], [[1w25]] - CvPleD + GMP
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===Hypoxia RR===
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*Hypoxia response regulator
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[[3c3w]], [[1zlj]] – MtDosR<br/ >
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**[[3c3w]], [[1zlj]] – MtDosR<br/ >
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[[3c57]] – MtDosR C terminal<br />
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**[[3c57]] – MtDosR C terminal<br />
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[[1zlk]] – MtDosR C terminal + DNA<br />
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**[[1zlk]] – MtDosR C terminal + DNA<br />
-
[[3zxo]] – MtDost ATP-binding domain<br />
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**[[3zxo]] – MtDost ATP-binding domain<br />
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===Transcriptional RR===
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*Transcriptional response regulator
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[[2zwm]] – BsYycF receiver domain<br/ >
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**[[2zwm]] – BsYycF receiver domain<br/ >
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[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase<br />
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**[[3ulq]] – BsComA DNA-binding domain + RR aspartate phosphatase<br />
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[[2pkx]] – EcPhoP regulatory domain<br />
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**[[2pkx]] – EcPhoP regulatory domain<br />
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[[3nhz]] – MtMtra N terminal<br />
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**[[3nhz]] – MtMtra N terminal<br />
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===Stress RR===
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*Stress response regulator
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[[3n0r]] – CVPhyR
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**[[3n0r]] – CVPhyR
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===Chemotaxis RR===
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*Chemotaxis response regulator
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[[3t8y]] - EcCheB<br />
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**[[3t8y]] - EcCheB<br />
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[[1mih]], [[1jbe]] – EcCheY<br />
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**[[1mih]], [[1jbe]] – EcCheY<br />
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[[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
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**[[1p6q]] – SmCheY2 - ''Sinorhizobium meliloti''<br />
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[[1p6u]] – SmCheY2 + BeF3<br />
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**[[1p6u]] – SmCheY2 + BeF3<br />
-
[[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
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**[[3hzh]] – CheY-3 + CheX – ''Borrelia burgdorferi''<br />
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[[1u0s]] – TmCheY + CheA<br />
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**[[1u0s]] – TmCheY + CheA<br />
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[[2chy]] – CheY – ''Salmonella typhimurium''
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**[[2chy]] – CheY – ''Salmonella typhimurium''
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===CheY-like RR===
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*CheY-like response regulator
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[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
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**[[3snk]] – RR – ''Mesorhizobium loti''<br/ >
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[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
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**[[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ >
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[[3i42]] – RR receiver domain – ''Methylobacter flagellates''<br />
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**[[3i42]] – RR receiver domain – ''Methylobacter flagellates''<br />
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[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >
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**[[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ >
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===Two-component RR===
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*Two-component response regulator
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[[2lpm]] – SmRR
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**[[2lpm]] – SmRR
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===Unspecified RR receiver domain===
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*Unspecified response regulator receiver domain
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[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ >
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**[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ >
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[[2a9r]] – SpRR + phosphate + Mg<br/ >
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**[[2a9r]] – SpRR + phosphate + Mg<br/ >
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[[2pln]] – HP1043 – ''Helicobacter pylori''<br/ >
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**[[2pln]] – HP1043 – ''Helicobacter pylori''<br/ >
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[[2qr3]] – RR – ''Bacteroides fragilis''<br/ >
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**[[2qr3]] – RR – ''Bacteroides fragilis''<br/ >
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[[2qxy]] – TmRR <br/ >
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**[[2qxy]] – TmRR <br/ >
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[[2qzj]] – RR – ''Clostridium difficile''<br/ >
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**[[2qzj]] – RR – ''Clostridium difficile''<br/ >
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[[3kht]] – RR – ''Hahella chejuensis''<br/ >
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**[[3kht]] – RR – ''Hahella chejuensis''<br/ >
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[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
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**[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
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[[3cz5]] – RR – ''Aurantimonas''<br/ >
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**[[3cz5]] – RR – ''Aurantimonas''<br/ >
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[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
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**[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
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[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
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**[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
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[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
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**[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
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[[4e7o]] – SpRR<br />
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**[[4e7o]] – SpRR<br />
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[[4e7p]] – SpRR + BeF3<br />
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**[[4e7p]] – SpRR + BeF3<br />
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[[2b4a]] – RR Bh3024 – ''Bacillus halodurans''<br />
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**[[2b4a]] – RR Bh3024 – ''Bacillus halodurans''<br />
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===Unspecified RR===
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*Unspecified response regulator
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[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
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**[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
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[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
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**[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
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[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
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**[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
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[[3gl9]] - TmRR<br/ >
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**[[3gl9]] - TmRR<br/ >
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[[4hye]] – SpRR<br />
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**[[4hye]] – SpRR<br />
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[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
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**[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
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[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
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**[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
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[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
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**[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
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[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
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**[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
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[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
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**[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
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[[3i5b]] – PaWspR GGDEF domain<br/ >
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**[[3i5b]] – PaWspR GGDEF domain<br/ >
-
[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
+
**[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
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[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
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**[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
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[[3p3q]] – McMmoQ (mutant) <br/ >
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**[[3p3q]] – McMmoQ (mutant) <br/ >
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[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
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**[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
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[[3nhm]] – MxRR<br/ >
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**[[3nhm]] – MxRR<br/ >
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[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
+
**[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
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[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
+
**[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
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[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
+
**[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
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[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
+
**[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
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[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
+
**[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
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[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
+
**[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
-
[[2oqr]] – MtRR Regx3 <br />
+
**[[2oqr]] – MtRR Regx3 <br />
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[[3sy8]] – PaRR Rocr <br />
+
**[[3sy8]] – PaRR Rocr <br />
-
[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
+
**[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
-
[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
+
**[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
-
[[4cbv]] – SpRR (mutant)<br />
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**[[4cbv]] – SpRR (mutant)<br />
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===RR complex with histidine kinase===
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*Response regulator complex with histidine kinase
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+
-
[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
+
-
[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
+
-
[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />
+
 +
**[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
 +
**[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
 +
**[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />
 +
}}

Revision as of 10:29, 7 December 2014

Template:STRUCTURE 1kgs

Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. For details see:
For PleD:

For PhoP:

For photosynthetic apparatus RR:

For WspR RR:

3D Structures of response regulator

Updated on 07-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

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