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Ribonucleotide reductase

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* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br />
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br />
* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br />
* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br />
-
For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
+
For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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==Class I RNR==
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*'''Class I ribonucleotide reductase'''
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===RNR large subunit===
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*Ribonucleotide reductase large subunit
-
[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR />
+
**[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR />
-
[[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''<br />
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**[[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli''<br />
-
[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br />
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**[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br />
-
''RNR large subunit complex''
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*''Ribonucleotide reductase large subunit complex''
-
[[3hnc]] – hRNR M1 + TTP – human<BR />
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**[[3hnc]] – hRNR M1 + TTP – human<BR />
-
[[3hnd]] – hRNR M1 + GDP + TTP<BR />
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**[[3hnd]] – hRNR M1 + GDP + TTP<BR />
-
[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR />
+
**[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR />
-
[[2wgh]] - hRNR M1 + ATP + Mg<BR />
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**[[2wgh]] - hRNR M1 + ATP + Mg<BR />
-
[[3paw]] - yRNR R1 + ATP<BR />
+
**[[3paw]] - yRNR R1 + ATP<BR />
-
[[3k8t]] - yRNR R1 + ADP analog<BR />
+
**[[3k8t]] - yRNR R1 + ADP analog<BR />
-
[[3s87]] - yRNR R1 + ADP + GTP<br />
+
**[[3s87]] - yRNR R1 + ADP + GTP<br />
-
[[3s8a]] - yRNR R1 (mutant) + GTP<br />
+
**[[3s8a]] - yRNR R1 (mutant) + GTP<br />
-
[[3tba]] - yRNR R1 (mutant) + GTP + ADP<br />
+
**[[3tba]] - yRNR R1 (mutant) + GTP + ADP<br />
-
[[3s8b]] - yRNR R1 + AMPPNP + CDP<br />
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**[[3s8b]] - yRNR R1 + AMPPNP + CDP<br />
-
[[3s8c]], [[3tb9]] - yRNR R1 (mutant) + AMPPNP + CDP<br />
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**[[3s8c]], [[3tb9]] - yRNR R1 (mutant) + AMPPNP + CDP<br />
-
[[2zlf]], [[2zlg]] - yRNR R1 + peptide<BR />
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**[[2zlf]], [[2zlg]] - yRNR R1 + peptide<BR />
-
[[2eud]] - yRNR R1 + ligand<BR />
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**[[2eud]] - yRNR R1 + ligand<BR />
-
[[3rsr]] – yRNR + inhibitor<br />
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**[[3rsr]] – yRNR + inhibitor<br />
-
[[2r1r]] - EcRNR R1 + TTP<BR />
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**[[2r1r]] - EcRNR R1 + TTP<BR />
-
[[3r1r]] - EcRNR R1 + AMPPNP<BR />
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**[[3r1r]] - EcRNR R1 + AMPPNP<BR />
-
[[4r1r]] - EcRNR R1 + GDP + TTP<BR />
+
**[[4r1r]] - EcRNR R1 + GDP + TTP<BR />
-
[[1qfn]] - EcRNR R1 + glutaredoxin 1<br />
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**[[1qfn]] - EcRNR R1 + glutaredoxin 1<br />
-
[[1peu]] - StRNR + DTP - ''Salmonella typhimurium''<br />
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**[[1peu]] - StRNR + DTP - ''Salmonella typhimurium''<br />
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===RNR small subunit===
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*RNR small subunit
-
[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR />
+
**[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR />
-
[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR />
+
**[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR />
-
[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR />
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**[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR />
-
[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR />
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**[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR />
-
[[2p1i]] – RNR R2 – ''Plasmodium yoelii''<BR />
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**[[2p1i]] – RNR R2 – ''Plasmodium yoelii''<BR />
-
[[2o1z]] - RNR R2 – ''Plasmodium vivax''<BR />
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**[[2o1z]] - RNR R2 – ''Plasmodium vivax''<BR />
-
[[1w68]], [[1h0n]], [[1h0o]], [[1xsm]] – mRNR R2 – mouse<BR />
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**[[1w68]], [[1h0n]], [[1h0o]], [[1xsm]] – mRNR R2 – mouse<BR />
-
[[1smq]], [[1sms]] – yRNR 2<BR />
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**[[1smq]], [[1sms]] – yRNR 2<BR />
-
[[4d8f]], [[4d8g]], [[4m1i]] - CtRNR R2 + Fe + Mn<br />
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**[[4d8f]], [[4d8g]], [[4m1i]] - CtRNR R2 + Fe + Mn<br />
-
[[1syy]] - CtRNR R2 + Fe + Pb– ''Chlamydia trachomatis''<BR />
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**[[1syy]] - CtRNR R2 + Fe + Pb– ''Chlamydia trachomatis''<BR />
-
[[2ani]] - CtRNR R2 (mutant) + Fe + Pb<BR />
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**[[2ani]] - CtRNR R2 (mutant) + Fe + Pb<BR />
-
[[4m1h]] - CtRNR R2 <br />
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**[[4m1h]] - CtRNR R2 <br />
-
[[4dr0]] - RNR + Mn – Bacillus subtilis<br />
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**[[4dr0]] - RNR + Mn – Bacillus subtilis<br />
-
[[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR />
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**[[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR />
-
[[3olj]] – hRNR M2<br />
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**[[3olj]] – hRNR M2<br />
-
[[1jk0]] – yRNR Y2+Y4<br />
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**[[1jk0]] – yRNR Y2+Y4<br />
-
[[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br />
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**[[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br />
-
[[2rcc]] – RNR – ''Bacillus halodurans''<br />
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**[[2rcc]] – RNR – ''Bacillus halodurans''<br />
-
[[4bmq]], [[4bmr]], [[4bmt]] - BcRNR + Fe – ''Bacillus cereus''<br />
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**[[4bmq]], [[4bmr]], [[4bmt]] - BcRNR + Fe – ''Bacillus cereus''<br />
-
[[4bmu]] - BcRNR + Mn<br />
+
**[[4bmu]] - BcRNR + Mn<br />
-
[[4n83]] - SsRNR + Mn<br />
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**[[4n83]] - SsRNR + Mn<br />
-
''RNR small subunit complex''
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*''Ribonucleotide reductase small subunit complex''
-
[[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR />
+
**[[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR />
-
[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR />
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**[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR />
-
[[1rnr]] – EcRNR R2 (mutant) + dopa<BR />
+
**[[1rnr]] – EcRNR R2 (mutant) + dopa<BR />
-
[[1w69]] – mRNR R2 + acetate<br />
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**[[1w69]] – mRNR R2 + acetate<br />
-
[[4bmo]], [[4bmp]] - BcRNR + NRDI <br />
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**[[4bmo]], [[4bmp]] - BcRNR + NRDI <br />
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===RNR small+large subunit===
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*Ribonucleotide reductase small+large subunit
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[[3uus]], [[4erm]] - EcRNR R1+ R2<br />
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**[[3uus]], [[4erm]] - EcRNR R1+ R2<br />
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[[4erp]] - EcRNR R1+ R2 + inhibitor<br />
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**[[4erp]] - EcRNR R1+ R2 + inhibitor<br />
-
[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR />
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**[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR />
-
[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR />
+
**[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR />
-
[[2bq1]] - StRNR R1+ R2
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**[[2bq1]] - StRNR R1+ R2
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==Class II RNR==
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*'''Class II ribonucleotide reductase'''
-
[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR />
+
**[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR />
-
[[1xjg]] - TmRNR + ATP-UDP<BR />
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**[[1xjg]] - TmRNR + ATP-UDP<BR />
-
[[1xjj]] - TmRNR + GTP<BR />
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**[[1xjj]] - TmRNR + GTP<BR />
-
[[1xjk]] - TmRNR + GTP-ADP<BR />
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**[[1xjk]] - TmRNR + GTP-ADP<BR />
-
[[1xjm]] - TmRNR + TTP<BR />
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**[[1xjm]] - TmRNR + TTP<BR />
-
[[1xje]] - TmRNR + TTP-GDP<BR />
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**[[1xje]] - TmRNR + TTP-GDP<BR />
-
[[1xjn]] - TmRNR + ATP-CDP<br />
+
**[[1xjn]] - TmRNR + ATP-CDP<br />
-
[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br />
+
**[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br />
-
[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br />
+
**[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br />
-
[[3o0q]] - TmRNR + TTP + GDP + Mg + adenosine <br />
+
**[[3o0q]] - TmRNR + TTP + GDP + Mg + adenosine <br />
-
[[1pem]] - StRNR R1 <BR />
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**[[1pem]] - StRNR R1 <BR />
-
[[1r2f]], [[2r2f]] - StRNR R2<br />
+
**[[1r2f]], [[2r2f]] - StRNR R2<br />
-
[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR />
+
**[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR />
-
[[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br />
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**[[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br />
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==Class III RNR==
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*'''Class III ribonucleotide reductase'''
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+
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[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br />
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-
[[1h7b]] – T4RNR (mutant) <br />
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 +
**[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br />
 +
**[[1h7b]] – T4RNR (mutant) <br />
 +
}}

Revision as of 07:40, 9 December 2014

Template:STRUCTURE 1xjf

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.

  • Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.
  • Class II RNR reduces ribonucleotide triphosphates using coenzyme B12.
  • Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center.

For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.

Contents

3D Structures of Ribonucleotide reductase

Updated on 09-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Ribonucleotide_reductase"
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