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4piv
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4piv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIV FirstGlance]. <br> | <table><tr><td colspan='2'>[[4piv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIV FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W4:4-[4-(1-BENZOFURAN-5-YL)PHENYL]-5-{[(3S)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>2W4</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W4:4-[4-(1-BENZOFURAN-5-YL)PHENYL]-5-{[(3S)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>2W4</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4piv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4piv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4piv RCSB], [http://www.ebi.ac.uk/pdbsum/4piv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4piv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4piv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4piv RCSB], [http://www.ebi.ac.uk/pdbsum/4piv PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Fatty-acid synthase]] | [[Category: Fatty-acid synthase]] | ||
| - | [[Category: Brown, K K | + | [[Category: Brown, K K]] |
| - | [[Category: Hardwicke, M A | + | [[Category: Hardwicke, M A]] |
| - | [[Category: Parrish, C A | + | [[Category: Parrish, C A]] |
| - | [[Category: Wang, L | + | [[Category: Wang, L]] |
| - | [[Category: Williams, S P | + | [[Category: Williams, S P]] |
[[Category: Fatty acid synthase]] | [[Category: Fatty acid synthase]] | ||
[[Category: Human fa]] | [[Category: Human fa]] | ||
[[Category: Keto-reductase]] | [[Category: Keto-reductase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 18:41, 25 December 2014
Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069
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