4q0z
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Protein-nucleic acid complex (complex III)== |
| + | <StructureSection load='4q0z' size='340' side='right' caption='[[4q0z]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4q0z]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0Z FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0r|4q0r]], [[4q0w|4q0w]], [[4q10|4q10]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0z RCSB], [http://www.ebi.ac.uk/pdbsum/4q0z PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rad2/XPG belongs to the flap nuclease family and is responsible for a key step of the eukaryotic nucleotide excision DNA repair (NER) pathway. To elucidate the mechanism of DNA binding by Rad2/XPG, we solved crystal structures of the catalytic core of Rad2 in complex with a substrate. Rad2 utilizes three structural modules for recognition of the double-stranded portion of DNA substrate, particularly a Rad2-specific alpha-helix for binding the cleaved strand. The protein does not specifically recognize the single-stranded portion of the nucleic acid. Our data suggest that in contrast to related enzymes (FEN1 and EXO1), the Rad2 active site may be more accessible, which would create an exit route for substrates without a free 5' end. | ||
| - | + | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.,Mietus M, Nowak E, Jaciuk M, Kustosz P, Studnicka J, Nowotny M Nucleic Acids Res. 2014 Aug 12. pii: gku729. PMID:25120270<ref>PMID:25120270</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jaciuk, M.]] | ||
| + | [[Category: Kustosz, P.]] | ||
| + | [[Category: Mietus, M.]] | ||
| + | [[Category: Nowak, E.]] | ||
| + | [[Category: Nowotny, M.]] | ||
| + | [[Category: Ba rossmann-like]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Hydrolase-dna complex]] | ||
| + | [[Category: Tfiih]] | ||
Revision as of 08:43, 27 August 2014
Protein-nucleic acid complex (complex III)
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