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4u6x

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'''Unreleased structure'''
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==Crystal Structure of HLA-A*0201 in complex with ALQDA, a 15 mer self-peptide==
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<StructureSection load='4u6x' size='340' side='right' caption='[[4u6x]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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The entry 4u6x is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4u6x]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U6X FirstGlance]. <br>
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Authors: Gras, S., Chabrol, E., Rossjohn, J.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u6y|4u6y]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6x RCSB], [http://www.ebi.ac.uk/pdbsum/4u6x PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chabrol, E]]
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[[Category: Gras, S]]
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[[Category: Rossjohn, J]]
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[[Category: Hla a*0201]]
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[[Category: Immune system]]
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[[Category: Ligandome]]
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[[Category: T cell]]
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[[Category: Tcr]]

Revision as of 11:13, 24 December 2014

Crystal Structure of HLA-A*0201 in complex with ALQDA, a 15 mer self-peptide

4u6x, resolution 1.68Å

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