3wi3
From Proteopedia
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wi3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wi3 PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wi3 RCSB], [http://www.ebi.ac.uk/pdbsum/3wi3 PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The initiation of eukaryotic chromosomal DNA replication requires the formation of an active replicative helicase at the replication origins of chromosomal DNA. Yeast Sld3 and its metazoan counterpart Treslin are the hub proteins mediating protein associations critical for the helicase formation. Here, we show the crystal structure of the central domain of Sld3 that is conserved in Sld3/Treslin family of proteins. The domain consists of two segments with 12 helices and is sufficient to bind to Cdc45, the essential helicase component. The structure model of the Sld3-Cdc45 complex, which is crucial for the formation of the active helicase, is proposed. | ||
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| + | Crystal structure of the homology domain of the eukaryotic DNA replication proteins sld3/treslin.,Itou H, Muramatsu S, Shirakihara Y, Araki H Structure. 2014 Sep 2;22(9):1341-7. doi: 10.1016/j.str.2014.07.001. Epub 2014 Aug, 7. PMID:25126958<ref>PMID:25126958</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:05, 24 September 2014
Crystal Structure of the Sld3/Treslin domain from yeast Sld3
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