4qlo
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qlo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QLO FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qlo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QLO FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qlo RCSB], [http://www.ebi.ac.uk/pdbsum/4qlo PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qlo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qlo RCSB], [http://www.ebi.ac.uk/pdbsum/4qlo PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Homoserine O-acetyltransferase (HTA) catalyzes the formation of L-O-acetyl-homoserine from L-homoserine through the transfer of an acetyl group from acetyl-CoA. This is the first committed step required for the biosynthesis of methionine in many fungi, Gram-positive bacteria and some Gram-negative bacteria. The structure of HTA from Staphylococcus aureus (SaHTA) has been determined to a resolution of 2.45 A. The structure belongs to the alpha/beta-hydrolase superfamily, consisting of two distinct domains: a core alpha/beta-domain containing the catalytic site and a lid domain assembled into a helical bundle. The active site consists of a classical catalytic triad located at the end of a deep tunnel. Structure analysis revealed some important differences for SaHTA compared with the few known structures of HTA. | ||
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| + | Structure of homoserine O-acetyltransferase from Staphylococcus aureus: the first Gram-positive ortholog structure.,Thangavelu B, Pavlovsky AG, Viola R Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1340-5. doi:, 10.1107/S2053230X14018664. Epub 2014 Sep 25. PMID:25286936<ref>PMID:25286936</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homoserine O-acetyltransferase]] | [[Category: Homoserine O-acetyltransferase]] | ||
| - | [[Category: Pavlovsky, A G | + | [[Category: Pavlovsky, A G]] |
| - | [[Category: Thangavelu, B | + | [[Category: Thangavelu, B]] |
| - | [[Category: Viola, R E | + | [[Category: Viola, R E]] |
[[Category: Acetylco-a binding]] | [[Category: Acetylco-a binding]] | ||
[[Category: Acetyltransferase]] | [[Category: Acetyltransferase]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:44, 17 December 2014
Crystal Structure of homoserine o-acetyltransferase from Staphylococcus aureus
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