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Thymidylate synthase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Thymidylate synthase===
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*'''Thymidylate synthase'''
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[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
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**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
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[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
+
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
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[[4tms]], [[1tda]] - LcTS – ''Lactobacillus casei''<br />
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**[[4tms]], [[1tda]] - LcTS – ''Lactobacillus casei''<br />
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[[1tsw]], [[1tsz]] - LcTS (mutant)<br />
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**[[1tsw]], [[1tsz]] - LcTS (mutant)<br />
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[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
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**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
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[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
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**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
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[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]]- hTS – human<br />
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**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]]- hTS – human<br />
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[[3n5g]], [[4kpw]] – hTS His-tag<br />
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**[[3n5g]], [[4kpw]] – hTS His-tag<br />
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[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]] – hTS (mutant)<br />
+
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]] – hTS (mutant)<br />
-
[[3ix6]] – BmTS – ''Brucella melitensis''<br />
+
**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
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[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
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**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
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[[3ihi]] – mTS – mouse<br />
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**[[3ihi]] – mTS – mouse<br />
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[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
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**[[3v8h]] – TS – ''Burkholderia thailandensis''<br />
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3ge9, [[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
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**[[3ge9]], [[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
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[[4iqb]] – nTS – nematode<br />
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**[[4iqb]] – nTS – nematode<br />
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''Thymidylate synthase binary complex''
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*Thymidylate synthase binary complex
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[[1tdc]], [[1thy]], [[2tdm]] – LcTS + UMP<BR />
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**[[1tdc]], [[1thy]], [[2tdm]] – LcTS + UMP<BR />
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[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
+
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
-
[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
+
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
-
[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
+
**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
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[[1nje]] - LcTS + CMP<BR />
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**[[1nje]] - LcTS + CMP<BR />
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[[1tdb]] - LcTS + fluoro-UMP<BR />
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**[[1tdb]] - LcTS + fluoro-UMP<BR />
-
[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
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**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
-
[[4tmk]], [[5tmp]] - EcTS + inhibitor<br />
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**[[4tmk]], [[5tmp]] - EcTS + inhibitor<br />
-
[[1an5]] - EcTS + inhibitor<br />
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**[[1an5]] - EcTS + inhibitor<br />
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[[1fwm]] - EcTS (mutant) + inhibitor<br />
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**[[1fwm]] - EcTS (mutant) + inhibitor<br />
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[[1bid]] - EcTS + UMP<BR />
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**[[1bid]] - EcTS + UMP<BR />
-
[[1aob]], [[1bdu]] - EcTS + deoxyuridine derivative<br />
+
**[[1aob]], [[1bdu]] - EcTS + deoxyuridine derivative<br />
-
[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
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**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
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[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
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**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
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[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
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**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
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[[2vet]] - EcTS (mutant) + UMP<BR />
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**[[2vet]] - EcTS (mutant) + UMP<BR />
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[[3b9h]] - EcTS + nitro-UMP<BR />
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**[[3b9h]] - EcTS + nitro-UMP<BR />
-
[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
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**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
-
[[1tmk]] - TS + TMP – yeast<br />
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**[[1tmk]] - TS + TMP – yeast<br />
-
[[3h9k]] - hTS (mutant) + fluoro-UMP<BR />
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**[[3h9k]] - hTS (mutant) + fluoro-UMP<BR />
-
[[3hb8]] - hTS (mutant) + UMP<BR />
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**[[3hb8]] - hTS (mutant) + UMP<BR />
-
[[3ob7]] - hTS (mutant) + glutathione<br />
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**[[3ob7]] - hTS (mutant) + glutathione<br />
-
[[4g2o]] – hTS (mutant) + purpurogallin<br />
+
**[[4g2o]] – hTS (mutant) + purpurogallin<br />
-
[[4gd7]] – hTS + purpurogallin<br />
+
**[[4gd7]] – hTS + purpurogallin<br />
-
[[4g6w]] – hTS (mutant) + bromobenzine-triol<br />
+
**[[4g6w]] – hTS (mutant) + bromobenzine-triol<br />
-
[[3n5e]], [[4fgt]] - hTS + peptide inhibitor<br />
+
**[[3n5e]], [[4fgt]] - hTS + peptide inhibitor<br />
-
[[4e28]] - hTS + inhibitor<br />
+
**[[4e28]] - hTS + inhibitor<br />
-
[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
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**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
-
[[4e5o]] - mTS + UMP<BR />
+
**[[4e5o]] - mTS + UMP<BR />
-
[[4ein]] – mTS + substrate analog<br />
+
**[[4ein]] – mTS + substrate analog<br />
-
[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
+
**[[3uwl]] – TS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
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[[3uwl]] – TS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
+
**[[4g9u]] – TS + UMP – ''Trichinella spiralis''<br />
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[[4g9u]] – TS + UMP – Trichinella spiralis<br />
+
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
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[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
+
**[[3fnn]] - CgTS + FAD <br />
-
[[3fnn]] - CgTS + FAD <br />
+
**[[4h0u]] – CgTS + UMP<br />
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[[4h0u]] – CgTS + UMP<br />
+
**[[4irr]], [[4isw]] – nTS + UMP<br />
-
[[4irr]], [[4isw]] – nTS + UMP<br />
+
-
''Thymidylate synthase ternary complex''
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*Thymidylate synthase ternary complex
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[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
+
**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
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[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
+
**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
-
[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor+ UMP<BR />
+
**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor+ UMP<BR />
-
[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor+ UMP<BR />
+
**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor+ UMP<BR />
-
[[1lcb]] - LcTS + inhibitor+ TMP<BR />
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**[[1lcb]] - LcTS + inhibitor+ TMP<BR />
-
[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
+
**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
-
[[1tys]] - EcTS + inhibitor+ TMP<BR />
+
**[[1tys]] - EcTS + inhibitor+ TMP<BR />
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[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor+ TMP<BR />
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**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor+ TMP<BR />
-
[[1tlc]] - EcTS + inhibitor+ GMP<BR />
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**[[1tlc]] - EcTS + inhibitor+ GMP<BR />
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[[1syn]], [[1tsd]] - EcTS + inhibitor+ UMP<BR />
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**[[1syn]], [[1tsd]] - EcTS + inhibitor+ UMP<BR />
-
[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]] - EcTS + inhibitor+ UMP<BR />
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**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]] - EcTS + inhibitor+ UMP<BR />
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[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]] - EcTS (mutant) + inhibitor+ UMP<BR />
+
**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]] - EcTS (mutant) + inhibitor+ UMP<BR />
-
[[1tls]], [[1tsn]] - EcTS + inhibitor+ fluoro-UMP<BR />
+
**[[1tls]], [[1tsn]] - EcTS + inhibitor+ fluoro-UMP<BR />
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[[3bhl]], [[3bhr]] - EcTS + inhibitor+ nitro-UMP<BR />
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**[[3bhl]], [[3bhr]] - EcTS + inhibitor+ nitro-UMP<BR />
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[[1bjg]] - EcTS (mutant) + inhibitor+ fluoro-UMP<BR />
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**[[1bjg]] - EcTS (mutant) + inhibitor+ fluoro-UMP<BR />
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[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
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**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
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[[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]], [[2g8o]] - EcTS + inhibitor+ UMP<BR />
+
**[[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]], [[2g8o]] - EcTS + inhibitor+ UMP<BR />
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[[1nce]], [[2g8m]] - EcTS (mutant) + inhibitor+ UMP<BR />
+
**[[1nce]], [[2g8m]] - EcTS (mutant) + inhibitor+ UMP<BR />
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[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
+
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
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[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
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**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
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[[4knz]] - EcTS + deoxyuridine derivative + folate derivative<br />
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**[[4knz]] - EcTS + deoxyuridine derivative + folate derivative<br />
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[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
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**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
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[[1hvy]], [[1i00]] - hTS + drug + UMP<BR />
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**[[1hvy]], [[1i00]] - hTS + drug + UMP<BR />
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[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<BR />
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**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<BR />
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[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor+ UMP<BR />
+
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor+ UMP<BR />
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[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
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**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
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[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
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**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
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[[1f28]] - PcTS + inhibitor+ UMP<BR />
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**[[1f28]] - PcTS + inhibitor+ UMP<BR />
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[[2aaz]] - TS + inhibitor+ UMP – ''Filobasidiella neoformans''<br />
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**[[2aaz]] - TS + inhibitor+ UMP – ''Filobasidiella neoformans''<br />
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[[3qj7]] - MtTS + spermine + UMP <br />
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**[[3qj7]] - MtTS + spermine + UMP <br />
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[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
+
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
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[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
+
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
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[[4eb4]] - mTS + drug + UMP<BR />
+
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
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[[4iqq]] – nTS + UMP + raltitrexed<br />
+
**[[4eb4]] - mTS + drug + UMP<BR />
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**[[4iqq]] – nTS + UMP + raltitrexed<br />
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===Bifunctional dihydrofolate reductase-thymidylate synthase===
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*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
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[[Dihydrofolate reductase]]
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*'''Flavin-dependent thymidylate synthase ThyX'''
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+
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===Flavin-dependent thymidylate synthase ThyX===
+
-
 
+
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[[2af6]], [[3gwc]] - MtTS + FAD + halo-UMP<BR />
+
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[[3hzg]] - MtTS + FAD <br />
+
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[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
+
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[[2gq2]] - MtTS (mutant) + NADP<br />
+
-
[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP – ''Thermotoga maritima''<br />
+
-
[[1o24]] – TmTS<br />
+
-
[[1o25]] – TmTS + UMP<br />
+
-
[[1o2a]] – TmTS + FAD <br />
+
-
[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br />
+
-
[[1o26]] – TmTS + FAD + UMP<br />
+
-
[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
+
-
[[1o2b]] – TmTS + FAD + phosphate<br />
+
-
[[4gta]] – TmTS + FAD + UMP + folinic acid<br />
+
-
[[4gt9]] – TmTS + FAD + UMP + folate<br />
+
-
[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
+
-
[[4gte]] – TmTS (mutant) + FAD + folate<br />
+
-
[[4gtb]] – TmTS + FAD + UMP + raltitrexed<br />
+
-
[[3ge9]] - CgTS – ''Corynebacterium glutamicum''<br />
+
-
[[3fnn]] - CgTS + FAD <br />
+
-
[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''
+
 +
**[[2af6]], [[3gwc]] - MtTS + FAD + halo-UMP<BR />
 +
**[[3hzg]] - MtTS + FAD <br />
 +
**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
 +
**[[2gq2]] - MtTS (mutant) + NADP<br />
 +
**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP – ''Thermotoga maritima''<br />
 +
**[[1o24]] – TmTS<br />
 +
**[[1o25]] – TmTS + UMP<br />
 +
**[[1o2a]] – TmTS + FAD <br />
 +
**[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br />
 +
**[[1o26]] – TmTS + FAD + UMP<br />
 +
**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
 +
**[[1o2b]] – TmTS + FAD + phosphate<br />
 +
**[[4gta]] – TmTS + FAD + UMP + folinic acid<br />
 +
**[[4gt9]] – TmTS + FAD + UMP + folate<br />
 +
**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
 +
**[[4gte]] – TmTS (mutant) + FAD + folate<br />
 +
**[[4gtb]] – TmTS + FAD + UMP + raltitrexed<br />
 +
**[[3ge9]] - CgTS – ''Corynebacterium glutamicum''<br />
 +
**[[3fnn]] - CgTS + FAD <br />
 +
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:27, 15 December 2014

Template:STRUCTURE 4tmk Thymidylate synthase (TS) catalyzes the methylation of dUMP to dTMP using 5,10-methylenetetrahydrofolate as a cofactor. TS is essential for DNA replication and repair. TS inhibition at its folate-binding site is used in anticancer therapeutic drugs. In protozoa, dihydrofolate reductase (DHFR) and TS are expressed as a bifunctional monomeric enzyme (DHFR-TS) with the DHFR entity at the N terminal. DHFR and TS catalyze consecutive reactions in the dTMP biosynthesis. DHFR-TS inhibitors are potential drug targets against parasite-transferred diseases. There are two different types of TS – ThyA and ThyX. The types differ in their activity and structure. The TS ThyX are flavin-dependent enzymes.

3D structures of thymidylate synthase

Updated on 15-December-2014

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