Ubiquitin conjugating enzyme

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'''Ubiquitin conjugating enzyme''' (Ubc) or '''E2 enzyme''' catalyzes the second step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (Ubc) cysteine. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. Ubc13 makes a catalytically active heterodimer with MMS2.
'''Ubiquitin conjugating enzyme''' (Ubc) or '''E2 enzyme''' catalyzes the second step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (Ubc) cysteine. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. Ubc13 makes a catalytically active heterodimer with MMS2.
 +
</StructureSection>
== 3D Structures of ubiquitin conjugating enzyme ==
== 3D Structures of ubiquitin conjugating enzyme ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===Ubc===
+
*Ubiquitin conjugating enzyme
-
[[2aak]] – AtUbc – ''Arabidopsis thaliana'' <BR />
+
**[[2aak]] – AtUbc – ''Arabidopsis thaliana'' <BR />
-
[[2e2c]] – Ubc – ''Spisula solidissima'' <BR />
+
**[[2e2c]] – Ubc – ''Spisula solidissima'' <BR />
-
[[1q34]] – CeUbc – ''Caenorhabidis elegans'' <BR />
+
**[[1q34]] – CeUbc – ''Caenorhabidis elegans'' <BR />
-
[[2qcq]], [[1fzy]] – yUbc – yeast <BR />
+
**[[2qcq]], [[1fzy]] – yUbc – yeast <BR />
-
[[1jas]] – hUbc – human <BR />
+
**[[1jas]] – hUbc – human <BR />
-
[[2fo3]] – Ubc – ''Plasmodium vivax'' <BR />
+
**[[2fo3]] – Ubc – ''Plasmodium vivax'' <BR />
-
[[2h2y]] – PfUbc – ''Plasmodium falciparum'' <BR />
+
**[[2h2y]] – PfUbc – ''Plasmodium falciparum'' <BR />
-
[[1fxt]] – yUbc + ubiquitin <BR />
+
**[[1fxt]] – yUbc + ubiquitin <BR />
-
===Ubc1===
+
*Ubiquitin conjugating enzyme 1
-
[[1tte]] – yUbc (mutant) <BR />
+
**[[1tte]] – yUbc (mutant) <BR />
-
[[2aak]] – AtUbc <BR />
+
**[[2aak]] – AtUbc <BR />
-
[[1z3d]] – CeUbc <BR />
+
**[[1z3d]] – CeUbc <BR />
-
===Ubc2===
+
*Ubiquitin conjugating enzyme 2
-
[[1ayz]] – yUbc <BR />
+
**[[1ayz]] – yUbc <BR />
-
[[1z2u]] – CeUbc <BR />
+
**[[1z2u]] – CeUbc <BR />
-
===Ubc4===
+
*Ubiquitin conjugating enzyme 4
-
[[1qcq]] – yUbc <BR />
+
**[[1qcq]] – yUbc <BR />
-
[[4ii2]] – Ubc (mutant) + E1 + ATP – fission yeast<BR />
+
**[[4ii2]] – Ubc (mutant) + E1 + ATP – fission yeast<BR />
-
===Ubc5===
+
*Ubiquitin conjugating enzyme 5
-
[[2esk]], [[2c4o]], [[2clw]], [[3l1y]], [[3tgd]], [[2c4p]], [[1x23]] – hUbc <BR />
+
**[[2esk]], [[2c4o]], [[2clw]], [[3l1y]], [[3tgd]], [[2c4p]], [[1x23]] – hUbc <BR />
-
[[2eso]], [[2esp]], [[2esq]] – hUbc (mutant)<BR />
+
**[[2eso]], [[2esp]], [[2esq]] – hUbc (mutant)<BR />
-
[[1w4u]] – hUbc - NMR<BR />
+
**[[1w4u]] – hUbc - NMR<BR />
-
''Ubc5 complexes''
+
*Ubiquitin conjugating enzyme 5 complexes
-
[[1ur6]] – hUbc + Cnot4 - NMR<BR />
+
**[[1ur6]] – hUbc + Cnot4 - NMR<BR />
-
[[3eb6]] – Ubc + baculoviral IAP repeat-containing protein- frog<BR />
+
**[[3eb6]] – Ubc + baculoviral IAP repeat-containing protein- frog<BR />
-
[[4auq]] – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
+
**[[4auq]] – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
-
[[3ptf]], [[4ddg]], [[4ddi]] – hUbc + ubiquitin<BR />
+
**[[3ptf]], [[4ddg]], [[4ddi]] – hUbc + ubiquitin<BR />
-
[[2fuh]] – hUbc + ubiquitin - NMR<BR />
+
**[[2fuh]] – hUbc + ubiquitin - NMR<BR />
-
[[3a33]], [[3ugb]] – hUbc (mutant) + ubiquitin<BR />
+
**[[3a33]], [[3ugb]] – hUbc (mutant) + ubiquitin<BR />
-
[[3jvz]], [[3jw0]] – hUbc (mutant) + E3 NEDD4-2 + ubiquitin<BR />
+
**[[3jvz]], [[3jw0]] – hUbc (mutant) + E3 NEDD4-2 + ubiquitin<BR />
-
[[4ap4]] – hUbc + E3 Rnf4 + ubiquitin<BR />
+
**[[4ap4]] – hUbc + E3 Rnf4 + ubiquitin<BR />
-
[[3oj4]] – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
+
**[[3oj4]] – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
-
[[4a49]] – hUbc + E3 Cbl <BR />
+
**[[4a49]] – hUbc + E3 Cbl <BR />
-
[[4a4b]], [[4a4c]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
+
**[[4a4b]], [[4a4c]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
-
[[3l1z]] – hUbc + ubiquitin conjugating factor<BR />
+
**[[3l1z]] – hUbc + ubiquitin conjugating factor<BR />
-
[[3rpg]] – hUbc + E3 Ring2 + polycomb complex protein Bmi-1 <BR />
+
**[[3rpg]] – hUbc + E3 Ring2 + polycomb complex protein Bmi-1 <BR />
-
[[3zni]] – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide <BR />
+
**[[3zni]] – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide <BR />
-
===Ubc6===
+
*Ubiquitin conjugating enzyme 6
-
[[4jjq]] – hUbc + ubiquitin carboxyl terminal hydrolase <BR />
+
**[[4jjq]] – hUbc + ubiquitin carboxyl terminal hydrolase <BR />
-
===Ubc7===
+
*Ubiquitin conjugating enzyme 7
-
[[2ucz]] – yUbc <BR />
+
**[[2ucz]] – yUbc <BR />
-
[[2awf]], [[2cyx]] – hUbc <BR />
+
**[[2awf]], [[2cyx]] – hUbc <BR />
-
[[1c4z]] – hUbc + E3 HECT domain <BR />
+
**[[1c4z]] – hUbc + E3 HECT domain <BR />
-
[[1fbv]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
+
**[[1fbv]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
-
[[4jqu]] – hUbc + U7BR <BR />
+
**[[4jqu]] – hUbc + U7BR <BR />
-
[[3sqv]] – hUbc + secreted effector protein <BR />
+
**[[3sqv]] – hUbc + secreted effector protein <BR />
-
[[3sy2]] – hUbc + E3 Sopa <BR />
+
**[[3sy2]] – hUbc + E3 Sopa <BR />
-
===Ubc8===
+
*Ubiquitin conjugating enzyme 8
-
[[1y6l]], [[1wzw]], [[1wzv]] – hUbc <BR />
+
**[[1y6l]], [[1wzw]], [[1wzv]] – hUbc <BR />
-
[[2kjh]] – hUbc + ubiuqitin <BR />
+
**[[2kjh]] – hUbc + ubiuqitin <BR />
-
===Ubc9===
+
*Ubiquitin conjugating enzyme 9 see [[SUMO conjugating enzyme Ubc9]]
-
See [[SUMO conjugating enzyme Ubc9]]
+
*Ubiquitin conjugating enzyme 10
-
===Ubc10===
+
**[[1i7k]] – hUbc (mutant) <BR />
-
[[1i7k]] – hUbc (mutant) <BR />
+
*Ubiquitin conjugating enzyme 12 (NEDD8 conjugating enzyme; Ubc F)
-
===Ubc12 (NEDD8 conjugating enzyme; Ubc F)===
+
**[[3o2u]] – yUbc <BR />
 +
**[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits <BR />
 +
**[[1y8x]] – hUbc + E1 NEDD8 <BR />
 +
**[[2nvu]] – hUbc + E1 NEDD8 + NEDD8<BR />
 +
**[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
 +
**[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
 +
**[[4gao]] – hUbc + Dcn1-like protein <BR />
 +
**[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
-
[[3o2u]] – yUbc <BR />
+
*Ubiquitin conjugating enzyme 13
-
[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits <BR />
+
-
[[1y8x]] – hUbc + E1 NEDD8 <BR />
+
-
[[2nvu]] – hUbc + E1 NEDD8 + NEDD8<BR />
+
-
[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
+
-
[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
+
-
[[4gao]] – hUbc + Dcn1-like protein <BR />
+
-
[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
+
-
===Ubc13===
+
**[[1jbb]] – yUbc <BR />
 +
**[[1jat]] – yUbc/Mms2 <BR />
 +
**[[1j74]] – hMms2 <BR />
 +
**[[1j7d]] – hUbc/Mms2 <BR />
 +
**[[4fh1]] – hUbc (mutant) <BR />
-
[[1jbb]] – yUbc <BR />
+
*Ubiquitin conjugating enzyme 13 complexes
-
[[1jat]] – yUbc/Mms2 <BR />
+
-
[[1j74]] – hMms2 <BR />
+
-
[[1j7d]] – hUbc/Mms2 <BR />
+
-
[[4fh1]] – hUbc (mutant) <BR />
+
-
''Ubc13 complexes''
+
**[[2c2v]] – hUbc + CHIP + Uev1a <BR />
 +
**[[3hct]], [[3hcu]] – hUbc + TNF receptor associated factor 6 <BR />
 +
**[[4dhi]] – CeUbc + OTUB1 <BR />
 +
**[[4dhi]], [[4dhz]] – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde <BR />
 +
**[[4epo]], [[4orh]] – hUbc/Mms2 + E3 Rnf8 <BR />
 +
**[[3von]] – hUbc/Mms2 + OTUB1 <BR />
 +
**[[1zgu]] – hMms2 + ubiquitin - NMR <BR />
 +
**[[2gmi]] – hUbc/Mms2 (mutant) + ubiquitin <BR />
 +
**[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
 +
**[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
-
[[2c2v]] – hUbc + CHIP + Uev1a <BR />
+
*Ubiquitin conjugating enzyme B
-
[[3hct]], [[3hcu]] – hUbc + TNF receptor associated factor 6 <BR />
+
-
[[4dhi]] – CeUbc + OTUB1 <BR />
+
-
[[4dhi]], [[4dhz]] – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde <BR />
+
-
[[4epo]], [[4orh]] – hUbc/Mms2 + E3 Rnf8 <BR />
+
-
[[3von]] – hUbc/Mms2 + OTUB1 <BR />
+
-
[[1zgu]] – hMms2 + ubiquitin - NMR <BR />
+
-
[[2gmi]] – hUbc/Mms2 (mutant) + ubiquitin <BR />
+
-
[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
+
-
[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
+
-
===Ubc B===
+
**[[2yb6]] – hUbc<br />
 +
**[[2y4w]] – hUbc - NMR <BR />
 +
**[[2ybf]] – hUbc + Rad18<br />
-
[[2yb6]] – hUbc<br />
+
*Ubiquitin conjugating enzyme D
-
[[2y4w]] – hUbc - NMR <BR />
+
-
[[2ybf]] – hUbc + Rad18<br />
+
-
===Ubc D===
+
**[[2yho]] – hUbc D1 + E3 Mylip <BR />
 +
**[[4ldt]] – hUbc D2 + OTUB1 + ubiquitin <BR />
 +
**[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
-
[[2yho]] – hUbc D1 + E3 Mylip <BR />
+
*Ubiquitin conjugating enzyme E1
-
[[4ldt]] – hUbc D2 + OTUB1 + ubiquitin <BR />
+
-
[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
+
-
===Ubc E1===
+
**[[3bzh]] – hUbc <BR />
-
[[3bzh]] – hUbc <BR />
+
*Ubiquitin conjugating enzyme G2
-
===Ubc G2===
+
**[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
 +
**[[2kly]] – hUbc - NMR<BR />
 +
**[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
 +
**[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />
-
[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
+
*Ubiquitin conjugating enzyme H
-
[[2kly]] – hUbc - NMR<BR />
+
-
[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
+
-
[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />
+
-
===Ubc H===
+
**[[2z5d]] – hUbc <BR />
-
[[2z5d]] – hUbc <BR />
+
*Ubiquitin conjugating enzyme J2
-
===Ubc J2===
+
**[[2f4w]] – hUbc <BR />
-
[[2f4w]] – hUbc <BR />
+
*Ubiquitin conjugating enzyme N
-
===Ubc N===
+
**[[4dhj]] – hUbc + ubiquitin + OTUB1<BR />
-
[[4dhj]] – hUbc + ubiquitin + OTUB1<BR />
+
*Ubiquitin conjugating enzyme Q
-
===Ubc Q===
+
**[[2qgx]] – hUbc <BR />
-
[[2qgx]] – hUbc <BR />
+
*Ubiquitin conjugating enzyme R1
-
===Ubc R1===
+
**[[3rz3]] – hUbc + inhibitor <BR />
 +
**[[4mdk]] – hUbc + ubiquitin + inhibitor <BR />
-
[[3rz3]] – hUbc + inhibitor <BR />
+
*Ubiquitin conjugating enzyme S
-
[[4mdk]] – hUbc + ubiquitin + inhibitor <BR />
+
-
 
+
-
===Ubc S===
+
[[1zdn]] – hUbc <BR />
[[1zdn]] – hUbc <BR />

Revision as of 09:53, 16 December 2014

Structure of human ubiquitin conjugating enzyme 2 (PDB entry 1ayz)

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Contents

3D Structures of ubiquitin conjugating enzyme

Updated on 16-December-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Ubiquitin conjugating enzyme
    • 2aak – AtUbc – Arabidopsis thaliana
    • 2e2c – Ubc – Spisula solidissima
    • 1q34 – CeUbc – Caenorhabidis elegans
    • 2qcq, 1fzy – yUbc – yeast
    • 1jas – hUbc – human
    • 2fo3 – Ubc – Plasmodium vivax
    • 2h2y – PfUbc – Plasmodium falciparum
    • 1fxt – yUbc + ubiquitin
  • Ubiquitin conjugating enzyme 1
  • Ubiquitin conjugating enzyme 2
  • Ubiquitin conjugating enzyme 4
    • 1qcq – yUbc
    • 4ii2 – Ubc (mutant) + E1 + ATP – fission yeast
  • Ubiquitin conjugating enzyme 5
  • Ubiquitin conjugating enzyme 5 complexes
    • 1ur6 – hUbc + Cnot4 - NMR
    • 3eb6 – Ubc + baculoviral IAP repeat-containing protein- frog
    • 4auq – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin
    • 3ptf, 4ddg, 4ddi – hUbc + ubiquitin
    • 2fuh – hUbc + ubiquitin - NMR
    • 3a33, 3ugb – hUbc (mutant) + ubiquitin
    • 3jvz, 3jw0 – hUbc (mutant) + E3 NEDD4-2 + ubiquitin
    • 4ap4 – hUbc + E3 Rnf4 + ubiquitin
    • 3oj4 – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin
    • 4a49 – hUbc + E3 Cbl
    • 4a4b, 4a4c – hUbc + E3 Cbl + ZAP-70 peptide
    • 3l1z – hUbc + ubiquitin conjugating factor
    • 3rpg – hUbc + E3 Ring2 + polycomb complex protein Bmi-1
    • 3zni – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide
  • Ubiquitin conjugating enzyme 6
    • 4jjq – hUbc + ubiquitin carboxyl terminal hydrolase
  • Ubiquitin conjugating enzyme 7
    • 2ucz – yUbc
    • 2awf, 2cyx – hUbc
    • 1c4z – hUbc + E3 HECT domain
    • 1fbv – hUbc + E3 Cbl + ZAP-70 peptide
    • 4jqu – hUbc + U7BR
    • 3sqv – hUbc + secreted effector protein
    • 3sy2 – hUbc + E3 Sopa
  • Ubiquitin conjugating enzyme 8
  • Ubiquitin conjugating enzyme 10
    • 1i7k – hUbc (mutant)
  • Ubiquitin conjugating enzyme 12 (NEDD8 conjugating enzyme; Ubc F)
    • 3o2u – yUbc
    • 1tt5 – hUbc + E1 Uba3, APPBP1 subunits
    • 1y8x – hUbc + E1 NEDD8
    • 2nvu – hUbc + E1 NEDD8 + NEDD8
    • 3fn1 – hUbc + E1 NEDD8-activating enzyme
    • 3tdu – hUbc + cullin-1 + Dcn1-like protein
    • 4gao – hUbc + Dcn1-like protein
    • 3tdi – hUbc + defective in cullin neddylation protein
  • Ubiquitin conjugating enzyme 13
  • Ubiquitin conjugating enzyme 13 complexes
    • 2c2v – hUbc + CHIP + Uev1a
    • 3hct, 3hcu – hUbc + TNF receptor associated factor 6
    • 4dhi – CeUbc + OTUB1
    • 4dhi, 4dhz – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde
    • 4epo, 4orh – hUbc/Mms2 + E3 Rnf8
    • 3von – hUbc/Mms2 + OTUB1
    • 1zgu – hMms2 + ubiquitin - NMR
    • 2gmi – hUbc/Mms2 (mutant) + ubiquitin
    • 4ip3, 3w31 – hUbc + Orf169b
    • 2oxq – Ubc + CHIP U-box - zebrafish
  • Ubiquitin conjugating enzyme B
  • Ubiquitin conjugating enzyme D
    • 2yho – hUbc D1 + E3 Mylip
    • 4ldt – hUbc D2 + OTUB1 + ubiquitin
    • 4bvu – hUbc D3 + OspG + ubiquitin
  • Ubiquitin conjugating enzyme E1
  • Ubiquitin conjugating enzyme G2
    • 3fsh – hUbc + autocrine motility factor receptor
    • 2kly – hUbc - NMR
    • 2lxp – hUbc + AMFR peptide - NMR
    • 3h8k, 4lad – hUbc + AMFR peptide
  • Ubiquitin conjugating enzyme H
  • Ubiquitin conjugating enzyme J2
  • Ubiquitin conjugating enzyme N
    • 4dhj – hUbc + ubiquitin + OTUB1
  • Ubiquitin conjugating enzyme Q
  • Ubiquitin conjugating enzyme R1
    • 3rz3 – hUbc + inhibitor
    • 4mdk – hUbc + ubiquitin + inhibitor
  • Ubiquitin conjugating enzyme S

1zdn – hUbc

Ubc T

4ccg – hUbc + E3 ubiquitin-protein ligase Fancl

Ubc Uev-1

2a4d – hUbc catalytic domain
2hlw – hUbc catalytic domain - NMR
3e95 – PfUbc + ubiquitin carrier protein

Ubc E2-25KDa (Huntington interacting protein 2 HIP-2)

1yla, 2bep – hHIP-2
3e46 – hHIP-2 (mutant)
2bf8 – hHIP-2 + SUMO
2o25 – hHIP-2 + Ubc9
3f92 – hHIP-2/azorectase (mutant)
3k9o, 3k9p – hHIP-2 + ubiquitin

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David A Taves

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