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Actinin

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{{STRUCTURE_2eyi| PDB=2eyi | SIZE=400| SCENE=Actinin/Cv/1 |right|CAPTION=Alpha-actinin-1 [[2eyi]] }}
{{STRUCTURE_2eyi| PDB=2eyi | SIZE=400| SCENE=Actinin/Cv/1 |right|CAPTION=Alpha-actinin-1 [[2eyi]] }}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== α-actinin-1 (aA1) ===
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* α-actinin-1 (aA1)
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[[2eyi]], [[2eyn]] - haA1 ABD – human
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=== α-actinin-2 (aA2) ===
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**[[2eyi]], [[2eyn]] - haA1 ABD – human
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[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br />
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* α-actinin-2 (aA2)
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[[1hc2]], [[1quu]] – haA2 SR<br />
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[[1hci]] – haA2 repeats 1-4
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=== α-actinin-3 (aA3) ===
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**[[1h8b]] – haA2 EF hands+rTitin Z-repeat – rabbit<br />
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**[[1hc2]], [[1quu]] – haA2 SR<br />
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**[[1hci]] – haA2 repeats 1-4
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[[3lue]] – haA3+hActin <br />
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* α-actinin-3 (aA3)
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[[1tjt]], [[1wku]] – haA3 ABD<br />
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[[1g8x]] – aA3 1-2 repeats/myosin II heavy chain – ''Dictyostelium discoideum''
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=== α-actinin-4 (aA4) ===
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**[[3lue]] – haA3+hActin <br />
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**[[1tjt]], [[1wku]] – haA3 ABD<br />
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**[[1g8x]] – aA3 1-2 repeats/myosin II heavy chain – ''Dictyostelium discoideum''
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[[2r0o]] – haA4 ABD (mutant)<br />
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* α-actinin-4 (aA4)
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[[1wlx]] – haA4 SR – NMR<br />
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[[1sjj]] – aA – chicken - cryoEM<br />
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[[1ydi]] – haA4 vinculin-binding site + vinculin<br />
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===β-actinin (bA)===
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**[[2r0o]] – haA4 ABD (mutant)<br />
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**[[1wlx]] – haA4 SR – NMR<br />
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**[[1sjj]] – aA – chicken - cryoEM<br />
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**[[1ydi]] – haA4 vinculin-binding site + vinculin<br />
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[[3aa0]], [[3aae]] – cbA + leucine-rich containing protein peptide – chicken<br />
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*β-actinin (bA)
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[[3lk2]], [[3lk3]] - + leucine-rich containing protein fragment<br />
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[[3aa1]] - cbA + pleckstrin peptide<br />
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[[3aa6]], 3lk4 - cbA + Cd2-associated protein peptide<br />
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[[3aa7]] – cbA (mutant)<br />
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[[3aaa]] – cbA + myotrophin
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**[[3aa0]], [[3aae]] – cbA + leucine-rich containing protein peptide – chicken<br />
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**[[3lk2]], [[3lk3]] - + leucine-rich containing protein fragment<br />
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**[[3aa1]] - cbA + pleckstrin peptide<br />
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**[[3aa6]], 3lk4 - cbA + Cd2-associated protein peptide<br />
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**[[3aa7]] – cbA (mutant)<br />
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**[[3aaa]] – cbA + myotrophin
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:39, 12 November 2014

Template:STRUCTURE 2eyi

Actinin attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes. ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform. ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see Group:MUZIC:actinin2. ACTN3 encodes aA3 which anchors actin at the muscle Z-disk. ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. Actinins contain a 3-helix bundle which is called spectrin repeat (SR).

3D Structures of Actinin

Updated on 12-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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