Ankyrin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Ankyrin===
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*Ankyrin
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[[1n11]] – hANK-1 D34 region – human<br />
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[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />
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[[3f59]] – hANK-1 spectrin-binding domain<br />
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[[3du1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />
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[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
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[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
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[[3so8]] – hANK-A residues 149-310<br />
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[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
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[[1svx]] – dANK + maltose-binding protein<br />
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[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
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[[2aja]] – ANK – Legionella pneumophila<br />
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[[3hra]] – ANK – Enterococus faecalis<br />
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[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
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===Gankyrin===
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**[[1n11]] – hANK-1 D34 region – human<br />
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[[1uoh]], [[1qym]] – hGANK<br />
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**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />
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[[1tr4]] – hGANK – NMR<br />
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**[[3f59]] – hANK-1 spectrin-binding domain<br />
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[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
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**[[3du1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />
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**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
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**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
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**[[3so8]] – hANK-A residues 149-310<br />
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**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
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**[[1svx]] – dANK + maltose-binding protein<br />
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**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
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**[[2aja]] – ANK – Legionella pneumophila<br />
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**[[3hra]] – ANK – Enterococus faecalis<br />
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**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
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*Gankyrin
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**[[1uoh]], [[1qym]] – hGANK<br />
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**[[1tr4]] – hGANK – NMR<br />
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**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:07, 17 November 2014

Human ankyrin-1 D34 region complex with Cl- (green) and Br- (dark red) ions 1n11

Drag the structure with the mouse to rotate

Ankyrins (ANK) are proteins which mediate the attachment of membrane proteins to the membrane skeleton. Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family.Also known as Arpp or stretch responsive muscle ANKRD2 gene contains 9 exons and spans about 12 kb. The 5-prime flanking region contains a TATA box and binding motifs for the muscle-specific transcription factors MYOD and for NF-kappa-B. Kemp et.al cloned mouse Ankrd2 and obtained a partial human ANKRD2 cDNA. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. Northern blot and PCR analyses detected expression of mouse Ankrd2 only in tissues containing striated muscle. In situ hybridization of mouse embryos showed that Ankrd2 expression was restricted to the myotome of somites at day 9.5. At later developmental stages, Ankrd2 expression was stronger in outer back muscles than intercostal muscles, and it was not expressed in heart. See also


3D Structures of Ankyrin

Updated on 17-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Narendra Kumar Verma

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