This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Beta-lactamase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
- 
{{STRUCTURE_3bm6| PDB=3bm6 | SIZE=400| SCENE=Beta-lactamase/Beta-lactamase/1|right|CAPTION=Beta-lactamase class D dimer complex with boronic acid derivative, [[3bm6]] }}
{{STRUCTURE_3bm6| PDB=3bm6 | SIZE=400| SCENE=Beta-lactamase/Beta-lactamase/1|right|CAPTION=Beta-lactamase class D dimer complex with boronic acid derivative, [[3bm6]] }}
Line 7: Line 6:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===β-lactamase class A===
+
*'''β-lactamase class A'''
-
 
+
-
[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
+
-
[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]] - EcBlac A Tem-1<br />
+
-
[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
+
-
[[1li0]] - EcBlac A Tem-32 (mutant) <br />
+
-
[[1li9]] - EcBlac A Tem-34 (mutant) <br />
+
-
[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
+
-
[[3toi]] - EcBlac A Tem-116 (mutant)<br />
+
-
[[4id4]] – EcBlac/PaBlac Tem<br />
+
-
[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]] - EcBlac A Toho-1 (mutant) <br />
+
-
[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
+
-
[[3c5a]] – EcBlac A Kpc-2<br />
+
-
[[1ylj]], [[1ylp]], [[1ylt]], [[1ylw]], [[1yly]], [[1ylz]], [[1ym1]], [[1yms]], [[1ymx]], [[2p74]] – EcBlac A Ctx-M<br />
+
-
[[3hre]] - EcBlac A Ctx-M (mutant) <br />
+
-
[[3o3v]] – EcBlac peptidase domain<br />
+
-
[[1o7e]], [[1n4o]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
+
-
[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br />
+
-
[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1<br />
+
-
[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br />
+
-
[[1n9b]] – KpBlac A Shv-2<br />
+
-
[[2qpn]] – KpBlac A Ges-1<br />
+
-
[[3ni9]] - PaBlac A Ges-2<br />
+
-
[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
+
-
[[1kge]], [[1kgf]], [[1kgg]], [[1ome]]– SaBlac A (mutant) - S''taphylococcus aureus''<br />
+
-
[[3blm]] – SaBlac A<br />
+
-
[[1mbl]], [[3ly3]], [[3soi]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
+
-
[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
+
-
[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
+
-
[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''<br />
+
-
[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
+
-
[[3zdj]], [[4b88]] – Blac – precambrian<br />
+
-
 
+
-
===Extended-spectrum β-lactamase class A===
+
-
[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
+
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
-
[[3nia]] - PaESBL A GES-2 + inhibitor<br />
+
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]] - EcBlac A Tem-1<br />
-
[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
+
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
-
[[3v3s]] – PaESBL GES-18<br />
+
**[[1li0]] - EcBlac A Tem-32 (mutant) <br />
-
[[1e25]] – PaESBL PER-1 (mutant)<br />
+
**[[1li9]] - EcBlac A Tem-34 (mutant) <br />
-
[[3znw]] - CfESBL PER-2 + antribiotic – ''Citrobacter freundii''<br />
+
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
-
[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br />
+
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
-
[[3tsg]] – AbESBL GES-14<br />
+
**[[4id4]] – EcBlac/PaBlac Tem<br />
-
[[2qpn]] – KpESBL A GES-1<br />
+
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]] - EcBlac A Toho-1 (mutant) <br />
-
[[3ni9]] - PaESBL A GES-2<br />
+
**[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
-
[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br />
+
**[[3c5a]] – EcBlac A Kpc-2<br />
-
[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br />
+
**[[1ylj]], [[1ylp]], [[1ylt]], [[1ylw]], [[1yly]], [[1ylz]], [[1ym1]], [[1yms]], [[1ymx]], [[2p74]] – EcBlac A Ctx-M<br />
-
[[4hbt]] – EcESBL Ctx-M-15<br />
+
**[[3hre]] - EcBlac A Ctx-M (mutant) <br />
-
[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
+
**[[3o3v]] – EcBlac peptidase domain<br />
 +
**[[1o7e]], [[1n4o]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
 +
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br />
 +
**[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1<br />
 +
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br />
 +
**[[1n9b]] – KpBlac A Shv-2<br />
 +
**[[2qpn]] – KpBlac A Ges-1<br />
 +
**[[3ni9]] - PaBlac A Ges-2<br />
 +
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
 +
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
 +
**[[3blm]] – SaBlac A<br />
 +
**[[1mbl]], [[3ly3]], [[3soi]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
 +
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
 +
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
 +
**[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''<br />
 +
**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
 +
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
-
===β-lactamase class A binary complex===
+
*Extended-spectrum β-lactamase class A
-
[[1axb]] - EcBlac A (mutant) + transition state analog<br />
+
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
-
[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
+
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
-
[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
+
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
-
[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
+
**[[3v3s]] – PaESBL GES-18<br />
-
[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
+
**[[1e25]] – PaESBL PER-1 (mutant)<br />
-
[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
+
**[[3znw]] - CfESBL PER-2 + antribiotic – ''Citrobacter freundii''<br />
-
[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]] - KpBlac A Shv-1 + inhibitor<br />
+
**[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br />
-
[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
+
**[[3tsg]] – AbESBL GES-14<br />
-
[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
+
**[[2qpn]] – KpESBL A GES-1<br />
-
[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
+
**[[3ni9]] - PaESBL A GES-2<br />
-
[[3m2j]] - BlBlac A (mutant) + inhibitor<br />
+
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br />
-
[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
+
**[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br />
-
[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
+
**[[4hbt]] – EcESBL Ctx-M-15<br />
-
[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
+
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
-
[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
+
-
[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
+
-
[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''
+
-
===β-lactamase class A complex with β-lactamase inhibitor protein (Blip)===
+
*β-lactamase class A binary complex
-
[[3c7u]], [[3c7v]], [[1jtg]], [[2b5r]] – EcBlac A (mutant) + Protein Blip<br />
+
**[[1axb]] - EcBlac A (mutant) + transition state analog<br />
-
[[1jtd]], [[3gmw]] - EcBlac A + Protein Blip<br />
+
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
-
[[1s0w]], [[1xxm]] - EcBlac A + Protein Blip (mutant) <br />
+
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
-
[[2g2u]] - KpBlac A Shv-1 + Protein Blip<br />
+
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
-
[[2g2w]], [[3n4i]] - KpBlac A Shv-1 (mutant) + Protein Blip<br />
+
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
-
[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant) <br />
+
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
-
[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip<br />
+
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]] - KpBlac A Shv-1 + inhibitor<br />
-
[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''
+
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
 +
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
 +
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
 +
**[[3m2j]] - BlBlac A (mutant) + inhibitor<br />
 +
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
 +
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
 +
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
 +
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
 +
**[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
 +
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''
 +
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
-
===β-lactamase class B (Zn containing)===
+
**[[3c7u]], [[3c7v]], [[1jtg]], [[2b5r]] – EcBlac A (mutant) + Protein Blip<br />
 +
**[[1jtd]], [[3gmw]] - EcBlac A + Protein Blip<br />
 +
**[[1s0w]], [[1xxm]] - EcBlac A + Protein Blip (mutant) <br />
 +
**[[2g2u]] - KpBlac A Shv-1 + Protein Blip<br />
 +
**[[2g2w]], [[3n4i]] - KpBlac A Shv-1 (mutant) + Protein Blip<br />
 +
**[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant) <br />
 +
**[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip<br />
 +
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''
-
[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]] – BcBlac B - ''Bacillus cereus''<br />
+
*'''β-lactamase class B (Zn containing)'''
-
[[2m5c]] - BcBlac B – NMR<br />
+
-
[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
+
-
[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – ''Bacterioides fragilis''<br />
+
-
[[2znb]] - BfBlac B (Cd) <br />
+
-
[[3znb]] – BfBlac B (Zn, Hg) <br />
+
-
[[4znb]] - BfBlac B (mutant) <br />
+
-
[[1k07]] – FgBlac B]] - ''Fluoribacter gormanii''<br />
+
-
[[1l9y]] - FgBlac B (mutant) <br />
+
-
[[1ko2]], [[1ko3]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
+
-
[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
+
-
[[4awy]], [[4awz]] - PaBlac B Aim-1<br />
+
-
[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
+
-
[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
+
-
[[2fhx]] - PaBlac B Spm-1<br />
+
-
[[2x01]] - PaBlac Oxa-10 (mutant)<br />
+
-
[[2x02]] - PaBlac Oxa-10<br />
+
-
[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
+
-
[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br />
+
-
[[3vpe]] - SmBlac Smb-1<br />
+
-
[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''<br />
+
-
[[2zzi]] – TtBlac B (Fe) <br />
+
-
[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B<br />
+
-
[[2qin]], [[2qjs]] - StmBlac B (mutant) <br />
+
-
[[2gmn]], [[3lvz]] – BjBlac B – ''Bradyrhizobium japonicum''<br />
+
-
[[2p4z]] – Blac B – ''Thermoanaerobacter tengcongensis''<br />
+
-
[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
+
-
[[3r2u]] – SaBlac B<br />
+
-
[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]] - KpBlac B Ndm-1<br />
+
-
[[3srx]] - KpBlac B Ndm-1 (Cd) <br />
+
-
[[4h0d]] - KpBlac B Ndm-1 (Mn)<br />
+
-
[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
+
-
[[3s0z]] - EcBlac B Ndm-1<br />
+
-
[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
+
-
[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
+
-
[[3pg4]] – KpBlac Ndm-1
+
-
===β-lactamase class B binary complex===
+
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]] – BcBlac B - ''Bacillus cereus''<br />
 +
**[[2m5c]] - BcBlac B – NMR<br />
 +
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
 +
**[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – ''Bacterioides fragilis''<br />
 +
**[[2znb]] - BfBlac B (Cd) <br />
 +
**[[3znb]] – BfBlac B (Zn, Hg) <br />
 +
**[[4znb]] - BfBlac B (mutant) <br />
 +
**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
 +
**[[1l9y]] - FgBlac B (mutant) <br />
 +
**[[1ko2]], [[1ko3]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
 +
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
 +
**[[4awy]], [[4awz]] - PaBlac B Aim-1<br />
 +
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
 +
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
 +
**[[2fhx]] - PaBlac B Spm-1<br />
 +
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
 +
**[[2x02]] - PaBlac Oxa-10<br />
 +
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
 +
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br />
 +
**[[3vpe]] - SmBlac Smb-1<br />
 +
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''<br />
 +
**[[2zzi]] – TtBlac B (Fe) <br />
 +
**[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B<br />
 +
**[[2qin]], [[2qjs]] - StmBlac B (mutant) <br />
 +
**[[2gmn]], [[3lvz]] – BjBlac B – ''Bradyrhizobium japonicum''<br />
 +
**[[2p4z]] – Blac B – ''Thermoanaerobacter tengcongensis''<br />
 +
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
 +
**[[3r2u]] – SaBlac B<br />
 +
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]] - KpBlac B Ndm-1<br />
 +
**[[3srx]] - KpBlac B Ndm-1 (Cd) <br />
 +
**[[4h0d]] - KpBlac B Ndm-1 (Mn)<br />
 +
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
 +
**[[3s0z]] - EcBlac B Ndm-1<br />
 +
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
 +
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
 +
**[[3pg4]] – KpBlac Ndm-1
-
[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
+
*β-lactamase class B binary complex
-
[[1jt1]] – FgBlac + captopril <br />
+
-
[[1jje]], [[1jjt]], [[3lce]] - PaBlac B + inhibitor<br />
+
-
[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
+
-
[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br />
+
-
[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
+
-
[[2aio]] – StmBlac B + antibiotic<br />
+
-
[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]] - StmBlac B + inhibitor<br />
+
-
[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
+
-
[[1x8g]], [[2gkl]] – AhBlac B + inhibitor<br />
+
-
[[2qds]] – AhBlac B + captopril<br />
+
-
[[3m8t]] – BjBlac B + inhibitor<br />
+
-
[[2m5d]] - BcBlac B + inhibitor<br />
+
-
[[3q6v]] – SfBlac B + glycerol <br />
+
-
[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
+
-
[[4exy]], [[4exs]], [[4eyl]], [[4hky]] – KpBlac B Ndm-1+ inhibitor
+
-
===β-lactamase class C===
+
**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
 +
**[[1jt1]] – FgBlac + captopril <br />
 +
**[[1jje]], [[1jjt]], [[3lce]] - PaBlac B + inhibitor<br />
 +
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
 +
**[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br />
 +
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
 +
**[[2aio]] – StmBlac B + antibiotic<br />
 +
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]] - StmBlac B + inhibitor<br />
 +
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
 +
**[[1x8g]], [[2gkl]] – AhBlac B + inhibitor<br />
 +
**[[2qds]] – AhBlac B + captopril<br />
 +
**[[3m8t]] – BjBlac B + inhibitor<br />
 +
**[[2m5d]] - BcBlac B + inhibitor<br />
 +
**[[3q6v]] – SfBlac B + glycerol <br />
 +
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
 +
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]] – KpBlac B Ndm-1+ inhibitor
-
[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
+
*'''β-lactamase class C'''
-
[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br />
+
-
[[2qz6]] – Blac C – ''Pseudomonas fluorescens''
+
-
===β-lactamase class C binary complex===
+
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
 +
**[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br />
 +
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''
-
[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
+
*β-lactamase class C binary complex
-
[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
+
-
[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
+
-
[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor<br />
+
-
[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
+
-
[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
+
-
[[1rgz]] - EncBlac C + antribiotic<br />
+
-
[[1rgy]] - CfBlac C + antibiotic <br />
+
-
[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
+
-
[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
+
-
===β-lactamase class D===
+
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
 +
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
 +
**[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
 +
**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor<br />
 +
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
 +
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
 +
**[[1rgz]] - EncBlac C + antribiotic<br />
 +
**[1rgy]] - CfBlac C + antibiotic <br />
 +
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
 +
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
-
[[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]], [[1ddk]], [[1e3u]], [[1e4d]], [[1h8z]] – PaBlac D <br />
+
*'''β-lactamase class D'''
-
[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]], [[2wgw]], [[2wki]] - PaBlac D (mutant) <br />
+
-
[[1k56]], [[2k02]] - PaBlac Pse-2<br />
+
-
[[1g68]], [[1k4f]] – PaBlac Pse-4<br />
+
-
[[1g6a]] – PaBlac Pse-4 (mutant) <br />
+
-
[[1ko2]] – PaBlac Vim-2<br />
+
-
[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
+
-
[[1m6k]] – EcBlac D<br />
+
-
[[4mll]] - KpBlac D Oxa-1 + oxacillin<br />
+
-
[[3hbr]] – KpBlac D Oxa-48<br />
+
-
[[3if6]] - KpBlac D Oxa-46<br />
+
-
[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
+
-
===β-lactamase class D binary complex===
+
**[[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]], [[1ddk]], [[1e3u]], [[1e4d]], [[1h8z]] – PaBlac D <br />
 +
**[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]], [[2wgw]], [[2wki]] - PaBlac D (mutant) <br />
 +
**[[1k56]], [[2k02]] - PaBlac Pse-2<br />
 +
**[[1g68]], [[1k4f]] – PaBlac Pse-4<br />
 +
**[[1g6a]] – PaBlac Pse-4 (mutant) <br />
 +
**[[1ko2]] – PaBlac Vim-2<br />
 +
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
 +
**[[1m6k]] – EcBlac D<br />
 +
**[[4mll]] - KpBlac D Oxa-1 + oxacillin<br />
 +
**[[3hbr]] – KpBlac D Oxa-48<br />
 +
**[[3if6]] - KpBlac D Oxa-46<br />
 +
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
-
[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br />
+
*β-lactamase class D binary complex
-
[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
+
-
[[1k6s]] - PaBlac D + phenylboronic acid<br />
+
-
[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
+
-
[[3isg]] – EcBlac D + inhibitor<br />
+
-
[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
+
-
[[3znt]] - AbBlac D + inhibitor<br />
+
-
===AmpC β-lactamase===
+
**[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br />
 +
**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
 +
**[[1k6s]] - PaBlac D + phenylboronic acid<br />
 +
**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
 +
**[[3isg]] – EcBlac D + inhibitor<br />
 +
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
 +
**[[3znt]] - AbBlac D + inhibitor<br />
-
[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br />
+
*'''AmpC β-lactamase'''
-
[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]] - EcBlac (mutant)
+
-
[[1fcn ]]– EcBlac (mutant) + substrate<br />
+
-
[[1fco]], [[1i5q]], [[1kvl]] - EcBlac (mutant) + antibiotic<br />
+
-
[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]] - EcBlac + antibiotic<br />
+
-
[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]] - EcBlac + boronic acid inhibitor<br />
+
-
[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
+
-
[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]] - EcBlac + inhibitor<br />
+
-
[[1o07]] - EcBlac (mutant) + inhibitor<br />
+
-
[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
+
-
[[4hef]] - PaBlac + inhibitor<br />
+
-
[[4gzb]] – PaBlac<br />
+
-
===Carbapenemase===
+
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br />
 +
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]] - EcBlac (mutant)
 +
**[[1fcn]] – EcBlac (mutant) + substrate<br />
 +
**[[1fco]], [[1i5q]], [[1kvl]] - EcBlac (mutant) + antibiotic<br />
 +
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]] - EcBlac + antibiotic<br />
 +
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]] - EcBlac + boronic acid inhibitor<br />
 +
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
 +
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]] - EcBlac + inhibitor<br />
 +
**[[1o07]] - EcBlac (mutant) + inhibitor<br />
 +
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
 +
**[[4hef]] - PaBlac + inhibitor<br />
 +
**[[4gzb]] – PaBlac<br />
-
[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
+
*'''Carbapenemase'''
-
[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
+
-
[[3rxw]], [[3rxx]] – KpBlac Kpc<br />
+
-
[[2ov5]] - KpBlac A Kpc<br />
+
-
[[4eqi]] – SfBlac Sfc-1<br />
+
-
[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
+
-
[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
+
-
[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
+
-
[[1bue]] – EncBlac<br />
+
-
===Non-classified β-lactamase ===
+
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
 +
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
 +
**[[3rxw]], [[3rxx]] – KpBlac Kpc<br />
 +
**[[2ov5]] - KpBlac A Kpc<br />
 +
**[[4eqi]] – SfBlac Sfc-1<br />
 +
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
 +
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
 +
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
 +
**[[1bue]] – EncBlac<br />
-
[[1bsg]] – Blac – ''Streptomyces albus''<br />
+
*'''Other β-lactamase'''
-
[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
+
-
[[1gce]], [[1xx2]] - EncBlac <br />
+
-
[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
+
-
[[1dy6]] – SmBlac Sme-1<br />
+
-
[[1fr1]], [[1fr6]] – CfBlac <br />
+
-
[[1i2s]] – BlBlac<br />
+
-
[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br />
+
-
[[4jlf]] - MtBlac (mutant)<br />
+
-
[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
+
-
[[4df6]] – MtBlac + inhibitor<br />
+
-
[[2jc7]], [[3g4p]] – AbBlac <br />
+
-
[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
+
-
[[3i7j]] – Blac – ''Mycobacterium bovis''<br />
+
-
[[3lez]] – Blac – ''Oceanobacter iheyensis''<br />
+
-
[[3p09]] – Blac – ''Francisella tularensis''<br />
+
-
[[4blm]] - BlBlac<br />
+
-
[[4ewf]] – Blac – ''Sphaerobacter thermophilus''<br />
+
-
[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
+
-
[[3w4q]] – Blac – ''Burkholderia multivorans''<br />
+
-
[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
+
-
[[4k0x]] – AbBlac Oxa-23 <br />
+
-
===Non-classified β-lactamase binary complex===
+
**[[1bsg]] – Blac – ''Streptomyces albus''<br />
 +
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
 +
**[[1gce]], [[1xx2]] - EncBlac <br />
 +
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
 +
**[[1dy6]] – SmBlac Sme-1<br />
 +
**[[1fr1]], [[1fr6]] – CfBlac <br />
 +
**[[1i2s]] – BlBlac<br />
 +
**[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br />
 +
**[[4jlf]] - MtBlac (mutant)<br />
 +
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
 +
**[[4df6]] – MtBlac + inhibitor<br />
 +
**[[2jc7]], [[3g4p]] – AbBlac <br />
 +
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
 +
**[[3i7j]] – Blac – ''Mycobacterium bovis''<br />
 +
**[[3lez]] – Blac – ''Oceanobacter iheyensis''<br />
 +
**[[3p09]] – Blac – ''Francisella tularensis''<br />
 +
**[[4blm]] - BlBlac<br />
 +
**[[4ewf]] – Blac – ''Sphaerobacter thermophilus''<br />
 +
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
 +
**[[3w4q]] – Blac – ''Burkholderia multivorans''<br />
 +
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
 +
**[[4k0x]] – AbBlac Oxa-23 <br />
-
[[1ghm]], [[1ghp]], [[1pio]] - SaBlac (mutant) + antibiotic<br />
+
*Other β-lactamase binary complex
-
[[1blc]], [[1blh]]– SaBlac + inhibitor<br />
+
-
[[1bls ]]– EncBlac + phosphonate derivative <br />
+
-
[[1bul]] - EncBlac + penicillin derivative<br />
+
-
[[1ga0]] - EncBlac + inhibitor<br />
+
-
[[1i2w]] – BlBlac + cifoxitin<br />
+
-
[[3cg5]] – MtBlac + antibiotic<br />
+
-
[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
+
-
[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
+
-
[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
+
 +
**[[1ghm]], [[1ghp]], [[1pio]] - SaBlac (mutant) + antibiotic<br />
 +
**[[1blc]], [[1blh]] – SaBlac + inhibitor<br />
 +
**[[1bls]] – EncBlac + phosphonate derivative <br />
 +
**[[1bul]] - EncBlac + penicillin derivative<br />
 +
**[[1ga0]] - EncBlac + inhibitor<br />
 +
**[[1i2w]] – BlBlac + cifoxitin<br />
 +
**[[3cg5]] – MtBlac + antibiotic<br />
 +
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
 +
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
 +
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
 +
}}

Revision as of 10:03, 19 November 2014

Template:STRUCTURE 3bm6

Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases. Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.

3D Structures of Beta-lactamase

Updated on 19-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Beta-lactamase"
Personal tools