Calcium/Calmodulin-dependent protein kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
- 
{{STRUCTURE_3mfr| PDB=3mfr | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
{{STRUCTURE_3mfr| PDB=3mfr | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
Line 7: Line 6:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
=== CaMKK – CaM kinase kinase ===
+
* CaMKK – CaM kinase kinase
-
 
+
-
[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br />
+
-
=== CaMKI – specialized CaM kinase ===
+
**[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br />
-
[[1mxe]] – rCaMKI CBD+CaM – rat<br />
+
* CaMKI – specialized CaM kinase
-
[[1ckk]] – rCaMK CBD chain B+XlCaM<br />
+
-
[[1a06]] – rCaMK chain A<br />
+
-
=== CASK – membrane-associated CaMK ===
+
**[[1mxe]] – rCaMKI CBD+CaM – rat<br />
 +
**[[1ckk]] – rCaMK CBD chain B+XlCaM<br />
 +
**[[1a06]] – rCaMK chain A<br />
-
[[3mfr]] – hCASK CBD – human<br />
+
* CASK – membrane-associated CaMK
-
[[3mfs]] – hCASK+AMPPNP<br />
+
-
[[3mft]] – hCASK+Mn<br />
+
-
[[3c0g]] – hCASK kinase domain<br />
+
-
[[3c0h]] - hCASK kinase domain+AMPPNP<br />
+
-
[[3c0i]] - hCASK kinase domain+AMP<br />
+
-
[[3mfu]] - hCASK+AMPPNP+Mn<br />
+
-
=== DAPK – death-associated CaMK ===
+
**[[3mfr]] – hCASK CBD – human<br />
 +
**[[3mfs]] – hCASK+AMPPNP<br />
 +
**[[3mft]] – hCASK+Mn<br />
 +
**[[3c0g]] – hCASK kinase domain<br />
 +
**[[3c0h]] - hCASK kinase domain+AMPPNP<br />
 +
**[[3c0i]] - hCASK kinase domain+AMP<br />
 +
**[[3mfu]] - hCASK+AMPPNP+Mn<br />
-
[[2x0g]] – hDAPK RD+AD+CaM<br />
+
* DAPK – death-associated CaMK
-
[[2cke]] – hDAPK+inhibitor<br />
+
-
=== CaMKII – multifunctional CaM kinase ===
+
**[[2x0g]] – hDAPK RD+AD+CaM<br />
 +
**[[2cke]] – hDAPK+inhibitor<br />
-
[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br />
+
* CaMKII – multifunctional CaM kinase
-
[[2zv2]] – hCaMKII+STO-609<br />
+
-
[[2wel]] - hCaMKII δ chain D+CaM<br />
+
-
[[2w2c]] - hCaMKII δ chain ASD<br />
+
-
[[2vn9]] - hCaMKII δ chains A-B<br />
+
-
[[3bhh]] - hCaMKII β chains A-D<br />
+
-
[[2v7o]] - hCaMKII γ chain A<br />
+
-
[[2ux0]] - hCaMKII γ (mutant) chains A-F<br />
+
-
[[2jam]] - hCaMKI γ+peptides<br />
+
-
[[2jc6]] - hCaMKII δ chains A,C<br />
+
-
[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br />
+
-
[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br />
+
-
[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br />
+
-
[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
+
-
[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
+
-
=== CaMKIV ===
+
**[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br />
 +
**[[2zv2]] – hCaMKII+STO-609<br />
 +
**[[2wel]] - hCaMKII δ chain D+CaM<br />
 +
**[[2w2c]] - hCaMKII δ chain ASD<br />
 +
**[[2vn9]] - hCaMKII δ chains A-B<br />
 +
**[[3bhh]] - hCaMKII β chains A-D<br />
 +
**[[2v7o]] - hCaMKII γ chain A<br />
 +
**[[2ux0]] - hCaMKII γ (mutant) chains A-F<br />
 +
**[[2jam]] - hCaMKI γ+peptides<br />
 +
**[[2jc6]] - hCaMKII δ chains A,C<br />
 +
**[[1hkx]] - mCaMKII α chains A-N ASD - mouse<br />
 +
**[[3gp2]] – cCaMKII δ chain B+CaM – chicken<br />
 +
**[[3kk8]], [[3kk9]] – CeCaMKII – ''Caenorhabditis elegans''<br />
 +
**[[3kl8]] – CeCaMKII (mutant)+inhibitor<br />
 +
**[[3ksp]] – CaMKII ASD – ''Exiguobacterium sibiricum''<br />
-
[[2w4o]] – hCaMKIV+inhibitor<br />
+
* CaMKIV
 +
**[[2w4o]] – hCaMKIV+inhibitor<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:08, 19 November 2014

Template:STRUCTURE 3mfr

Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase (3mfr).

3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 19-November-2014

See also

Calcium-dependent protein kinase, a member of the CaM kinase family

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Calcium/Calmodulin-dependent_protein_kinase"
Personal tools