Cocaine esterase
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Cocaine esterase | |
| - | + | ||
| - | + | **[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | |
| + | **[[1l7r]], [[3pui]] - RhCocE (mutant) | ||
| - | [[1ju3]] – RhCocE + transition state inhibitor <br /> | + | *Cocaine esterase binary complex |
| - | [[1ju4]] – RhCocE + benzoic acid<br /> | + | |
| - | [[1l7q]] - RhCocE (mutant) + benzoic acid<br /> | + | **[[1ju3]] – RhCocE + transition state inhibitor <br /> |
| - | [[3ida]], [[3i2f]], [[3i2g]], [[3i2h]], [[3i2i]] - RhCocE (mutant) + DTT derivative<br /> | + | **[[1ju4]] – RhCocE + benzoic acid<br /> |
| - | [[3i2k]] - RhCocE + DTT derivative | + | **[[1l7q]] - RhCocE (mutant) + benzoic acid<br /> |
| + | **[[3ida]], [[3i2f]], [[3i2g]], [[3i2h]], [[3i2i]] - RhCocE (mutant) + DTT derivative<br /> | ||
| + | **[[3i2k]] - RhCocE + DTT derivative | ||
| + | }} | ||
| + | [[Category: Topic Page]] | ||
Revision as of 10:36, 20 November 2014
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 20-November-2014
