3wx2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WX2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WX2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wx1|3wx1]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wx1|3wx1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wx2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wx2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Hakoshima, T | + | [[Category: Hakoshima, T]] |
| - | [[Category: Handa, H | + | [[Category: Handa, H]] |
| - | [[Category: Hirano, Y | + | [[Category: Hirano, Y]] |
| - | [[Category: Ito, T | + | [[Category: Ito, T]] |
| - | [[Category: Mori, T | + | [[Category: Mori, T]] |
| - | [[Category: Yamaguchi, Y | + | [[Category: Yamaguchi, Y]] |
[[Category: E3 ubiquitin ligase]] | [[Category: E3 ubiquitin ligase]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
Revision as of 10:19, 25 December 2014
Mouse Cereblon thalidomide binding domain, native
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