Filamin
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | * Filamin A | |
| - | [[3isw]] – hFLNA repeat 21+CFTR peptide – human<br /> | + | **[[3isw]] – hFLNA repeat 21+CFTR peptide – human<br /> |
| - | [[3rgh]] - hFLNA repeat 10<br /> | + | **[[3rgh]] - hFLNA repeat 10<br /> |
| - | [[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> | + | **[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> |
| - | [[3hoc]] – hFLNA ABD (mutant)<br /> | + | **[[3hoc]] – hFLNA ABD (mutant)<br /> |
| - | [[4m9p]] - hFLNA domains 3-5<br /> | + | **[[4m9p]] - hFLNA domains 3-5<br /> |
| - | [[2aav]] - hFLNA domain 17 – NMR<br /> | + | **[[2aav]] - hFLNA domain 17 – NMR<br /> |
| - | [[2bp3]] - hFLNA domain 17+GPIB peptide<br /> | + | **[[2bp3]] - hFLNA domain 17+GPIB peptide<br /> |
| - | [[2k7p]] – hFLNA domains 16-17<br /> | + | **[[2k7p]] – hFLNA domains 16-17<br /> |
| - | [[2k7q]] - hFLNA domains 18-19<br /> | + | **[[2k7q]] - hFLNA domains 18-19<br /> |
| - | [[2j3s]] - hFLNA domains 19-21<br /> | + | **[[2j3s]] - hFLNA domains 19-21<br /> |
| - | [[2w0p]] - hFLNA domain 21+migfilin peptide<br /> | + | **[[2w0p]] - hFLNA domain 21+migfilin peptide<br /> |
| - | [[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br /> | + | **[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br /> |
| - | [[2k3t]] - hFLNA domain 23 – NMR<br /> | + | **[[2k3t]] - hFLNA domain 23 – NMR<br /> |
| - | [[3cnk]] - hFLNA DD<br /> | + | **[[3cnk]] - hFLNA DD<br /> |
| - | + | * Filamin B | |
| - | [[2wa5]], [[3fer]], [[2eea]] - hFLNB ABD<br /> | + | **[[2wa5]], [[3fer]], [[2eea]] - hFLNB ABD<br /> |
| - | [[2wa6]], [[2wa7]], [[4b7l]] - hFLNB ABD (mutant)<br /> | + | **[[2wa6]], [[2wa7]], [[4b7l]] - hFLNB ABD (mutant)<br /> |
| - | [[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br /> | + | **[[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br /> |
| - | + | * Filamin C | |
| - | [[2k9u]] – hFLNC+migfilin peptide<br /> | + | **[[2k9u]] – hFLNC+migfilin peptide<br /> |
| - | [[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br /> | + | **[[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br /> |
| - | [[2nqc]] - hFLNC domain 21<br /> | + | **[[2nqc]] - hFLNC domain 21<br /> |
| - | [[2d7q]] - hFLNC domain 23 – NMR<br /> | + | **[[2d7q]] - hFLNC domain 23 – NMR<br /> |
| - | [[3v8o]] - hFLNC domains 4,5 <br /> | + | **[[3v8o]] - hFLNC domains 4,5 <br /> |
| - | [[4mgx]] - hFLNC domains 4,5 + platelet glycoprotein peptide<br /> | + | **[[4mgx]] - hFLNC domains 4,5 + platelet glycoprotein peptide<br /> |
| - | [[1v05]] - hFLNC DD<br /> | + | **[[1v05]] - hFLNC DD<br /> |
| - | + | * Other Filamins | |
| - | + | ||
| - | + | ||
| + | **[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | ||
| + | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:58, 25 November 2014
Image:3hop.png
Crystal structure of Human Filamin A complex with phosphate, 3hop
- Filamin A (FLNA) has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
- Filamin B (FLNB) is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.
- Filamin C (FLNC) is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.
For more details on filaminC see Group:MUZIC:FilaminC. The images at the left and at the right correspond to one representative filamin structure, i.e. the crystal structure of human filamin A (3hop), it forms a [1]. Two phosphate ions are rendered as space filling objects.
3D structures of filamin
Updated on 25-November-2014
References
- ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442
