Histone methyltransferase

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{{#tree:id=OrganizedByTopic|openlevels=0
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[[1nw3]] – hHMT DOT1L – human
+
*DOT1L histone methyltransferase
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[[2igq]] – hHMT-1 C terminal
+
**[[1nw3]] – hHMT DOT1L – human
-
===Histone-lysine N-methyltransferase===
+
*Euchromatic histone methyltransferase
-
[[2j8a]] – KHMT SET1 RRM domain – yeast
+
**[[2igq]] – hHMT-1 C terminal
-
[[3s8s]] – hKHMT SETD1A RRM domain<br />
+
*Histone-lysine N-methyltransferase
-
[[2r3a]] – hKHMT Suv39H2<br />
+
-
[[3rq4]] - hKHMT Suv420H2<br />
+
-
[[3s8p]] - hKHMT Suv420H1<br />
+
-
[[3mts]] - hKHMT Suv39H1 chromo domain<br />
+
-
[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
+
-
[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
+
-
[[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br />
+
-
[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br />
+
-
[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br />
+
-
[[3lqh]] - hKHMT Mll Phd bromodomain<br />
+
-
[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br />
+
-
[[3bo5]] – hKHMT Setmar methyltransferase domain <br />
+
-
[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
+
-
[[3dlm]] - hKHMT Setmdb1 Tudor domain <br />
+
-
[[3n71]] - hKHMT Smyd1<br />
+
-
[[3rsn]], [[3s32]] – hKHMT Ash2 N terminal<br />
+
-
[[3toj]] – hKHMT Ash2 Spry domain<br />
+
-
[[4ijd]] – hKHMT Prdm9<br />
+
-
[[4mi0]] – hKHMT Ezh2<br />
+
-
[[4mi5]] – hKHMT Ezh2 SET domain<br />
+
-
[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
+
-
[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
+
-
[[1u2z]] – yKHMT C terminal<br />
+
-
[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br />
+
-
[[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br />
+
-
===Histone-lysine N-methyltransferase binary complexes===
+
**[[2j8a]] – KHMT SET1 RRM domain – yeast
-
[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
+
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
-
[[4nw3]] – hKHMT Mll CxxC domain + DNA <br />
+
**[[2r3a]] – hKHMT Suv39H2<br />
-
[[4pzi]] – hKHMT CxxC domain + DNA <br />
+
**[[3rq4]] - hKHMT Suv420H2<br />
-
[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
+
**[[3s8p]] - hKHMT Suv420H1<br />
-
[[3qow]] – hKHMT + SAM <br />
+
**[[3mts]] - hKHMT Suv39H1 chromo domain<br />
-
[[4fmu]] – hKHMT SETD2 + inhibitor <br />
+
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
-
[[4h12]] – hKHMT SETD2 + SAH <br />
+
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
-
[[3smt]] – hKHMT SETD3 + SAM <br />
+
**[[2lv9]] - hKHMT Mll5 residues 109-188 - NMR<br />
-
[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br />
+
**[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br />
-
[[3qox]], [[3sx0]] – hKHMT + SAH <br />
+
**[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br />
-
[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
+
**[[3lqh]] - hKHMT Mll Phd bromodomain<br />
-
[[2w5y]] – hKHMT Hrx methyltransferase domain +_SAH <br />
+
**[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br />
-
[[3lqi]], [[3lqj]] - hKHMT Mll Phd bromodomain + H3 peptide<br />
+
**[[3bo5]] – hKHMT Setmar methyltransferase domain <br />
-
[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br />
+
**[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
-
[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br />
+
**[[3dlm]] - hKHMT Setmdb1 Tudor domain <br />
-
[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
+
**[[3n71]] - hKHMT Smyd1<br />
-
[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
+
**[[3rsn]], [[3s32]] – hKHMT Ash2 N terminal<br />
-
[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
+
**[[3toj]] – hKHMT Ash2 Spry domain<br />
-
[[3rib]] – hKHMT Smyd2 + SAH<br />
+
**[[4ijd]] – hKHMT Prdm9<br />
-
[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
+
**[[4mi0]] – hKHMT Ezh2<br />
-
[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
+
**[[4mi5]] – hKHMT Ezh2 SET domain<br />
-
[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
+
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
-
[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
+
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
-
[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
+
**[[1u2z]] – yKHMT C terminal<br />
-
[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
+
**[[2l7p]] – AtKHMT Ashh2 CW domain – ''Arabidopsis thaliana'' - NMR<br />
-
[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
+
**[[2lxe]] – AtKHMT Suvr4 SET31 - NMR<br />
-
===Histone-lysine N-methyltransferase ternary complex===
+
*Histone-lysine N-methyltransferase binary complexes
-
[[2w5z]] – hKHMT Hrx methyltransferase domain +_SAH + histone peptide<br />
+
**[[2kkf]] – hKHMT Hrx CxxC domain +_DNA – NMR<br />
-
[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
+
**[[4nw3]] – hKHMT Mll CxxC domain + DNA <br />
-
[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
+
**[[4pzi]] – hKHMT CxxC domain + DNA <br />
-
[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br />
+
**[[3q0b]], [[3q0c]], [[3q0d]], [[3q0f]] – hKHMT SRA domain +_DNA <br />
-
[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
+
**[[3qow]] – hKHMT + SAM <br />
-
[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br />
+
**[[4fmu]] – hKHMT SETD2 + inhibitor <br />
-
[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
+
**[[4h12]] – hKHMT SETD2 + SAH <br />
-
[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
+
**[[3smt]] – hKHMT SETD3 + SAM <br />
-
[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
+
**[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br />
-
[[2f69]], [[3m53]] - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide<br />
+
**[[3qox]], [[3sx0]] – hKHMT + SAH <br />
-
[[3m54]], [[3m55]], [[3m56]], [[3m57]], [[3m58]], [[3m59]], [[3m5a]] - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide<br />
+
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
-
[[3cbm]] - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide<br />
+
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br />
-
[[4e47]], [[4jds]], [[4jlg]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br />
+
**[[3lqi]], [[3lqj]] - hKHMT Mll Phd bromodomain + H3 peptide<br />
-
[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br />
+
**[[3f2k]] – hKHMT Setmar SET domain + LYFA peptide<br />
-
[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
+
**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br />
-
[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
+
**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
-
[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br />
+
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
-
[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
+
**[[3lqi]], [[3lqj]] - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide<br />
-
[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
+
**[[3rib]] – hKHMT Smyd2 + SAH<br />
-
[[1zkk]] - hKHMT + SAH + H4 peptide <br />
+
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
-
[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
+
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
-
[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
+
**[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
-
[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
+
**[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
-
[[2g46]] – PvKHMT + SAH + H3 peptide<br />
+
**[[3cbp]] - hKHMT SET7/9 SET domain + sinefungin<br />
-
[[4au7]] - mKHMT + SAH + H4 peptide - mouse<br />
+
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
 +
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
-
===Histone-arginine N-methyltransferase (Carm1)===
+
*Histone-lysine N-methyltransferase ternary complex
-
[[2v74]], [[2v7e]] – mRHMT catalytic domain <br />
+
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
-
[[2obq]] – rRHMT N terminal - rat <br />
+
**[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
-
[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br />
+
**[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
-
[[3b3f]] – rRHMT catalytic domain + SAH<br />
+
**[[3f9w]], [[3f9x]], [[3f9y]], [[3f9z]] - hKHMT SETD8 SET domain + SAH + H4 peptide<br />
-
[[2y1w]], [[2y1x]] – hRHMT catalytic domain + sinefungin + indole inhibitor<br />
+
**[[4ij8]] - hKHMT SETD8 + SAM + H3 peptide<br />
-
[[4ikp]] – hRHMT catalytic domain + purine derivative<br />
+
**[[4j7i]], [[4j83]], [[4j8o]], [[4j7f]] - hKHMT SETD7 + SAH + TFIID peptide<br />
 +
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
 +
**[[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + SAH + H3 peptide<br />
 +
**[[1xqh]] - hKHMT SET7/9 SET domain + SAH + p53 peptide<br />
 +
**[[2f69]], [[3m53]] - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide<br />
 +
**[[3m54]], [[3m55]], [[3m56]], [[3m57]], [[3m58]], [[3m59]], [[3m5a]] - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide<br />
 +
**[[3cbm]] - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide<br />
 +
**[[4e47]], [[4jds]], [[4jlg]] - hKHMT SET7/9 SET domain + SAM + inhibitor<br />
 +
**[[3cbo]] - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide<br />
 +
**[[3os5]] - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide<br />
 +
**[[3qxy]], [[3rc0]] - hKHMT SETD6 SET domain + p65 peptide + SAM<br />
 +
**[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor<br />
 +
**[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide<br />
 +
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
 +
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
 +
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
 +
**[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
 +
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
 +
**[[2g46]] – PvKHMT + SAH + H3 peptide<br />
 +
**[[4au7]] - mKHMT + SAH + H4 peptide - mouse<br />
 +
*Histone-arginine N-methyltransferase (Carm1)
 +
 +
**[[2v74]], [[2v7e]] – mRHMT catalytic domain <br />
 +
**[[2obq]] – rRHMT N terminal - rat <br />
 +
**[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br />
 +
**[[3b3f]] – rRHMT catalytic domain + SAH<br />
 +
**[[2y1w]], [[2y1x]] – hRHMT catalytic domain + sinefungin + indole inhibitor<br />
 +
**[[4ikp]] – hRHMT catalytic domain + purine derivative<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:09, 27 November 2014

Template:STRUCTURE 3s7j

Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain.

3D Structures of histone methyltransferase

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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