Kinesin

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Kinesin heavy chain (KIF)===
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*Kinesin heavy chain (KIF)
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[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
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**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
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[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
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**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
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[[2g1l]] - hKIF1C FHA domain<br />
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**[[2g1l]] - hKIF1C FHA domain<br />
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[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
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**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
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[[1goj]] – NcKIF MD<br />
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**[[1goj]] – NcKIF MD<br />
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[[3bfn]] – hKIF22 MD<br />
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**[[3bfn]] – hKIF22 MD<br />
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[[3b6u]], [[3b6v]] – hKIF3B MD<br />
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**[[3b6u]], [[3b6v]] – hKIF3B MD<br />
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[[2rep]] – hKIFC1 MD<br />
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**[[2rep]] – hKIFC1 MD<br />
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[[2eh0]] - hKIF1B FHA domain – NMR<br />
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**[[2eh0]] - hKIF1B FHA domain – NMR<br />
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[[2edu]] – hKIF22 C-terminal – NMR<br />
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**[[2edu]] – hKIF22 C-terminal – NMR<br />
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[[2v14]] – hKIF16B<br />
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**[[2v14]] – hKIF16B<br />
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[[2heh]] – hKIF2C<br />
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**[[2heh]] – hKIF2C<br />
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[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
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**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
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[[1bg2]] – hKIF MD<br />
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**[[1bg2]] – hKIF MD<br />
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[[3kin]], [[2kin]] – rKIF MD - rat<br />
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**[[3kin]], [[2kin]] – rKIF MD - rat<br />
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[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
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**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
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[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
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**[[2ncd]], [[1cz7]] – DmKIF MD non-claret disjuctional (NCD) dimer – ''Drosophila melanogaster'' <br />
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[[2y5w]], [[2y65]] - DmKIF MD<br />
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**[[2y5w]], [[2y65]] - DmKIF MD<br />
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''Kinesin heavy chain complex with nucleotide''
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*''Kinesin heavy chain complex with nucleotide''
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[[3gbj]] – hKIF13B MD+ADP – human<br />
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**[[3gbj]] – hKIF13B MD+ADP – human<br />
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[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
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**[[1vfv]], [[1vfw]] – mKIF1A MD+Mg-AMPPNP<br />
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[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
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**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
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[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
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**[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
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[[1v8j]] – mKIF2C MD+Mg-ADP<br />
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**[[1v8j]] – mKIF2C MD+Mg-ADP<br />
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[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
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**[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
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[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
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**[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
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[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br />
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**[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br />
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[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
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**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
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[[2cjo]] – hKIF13+inhibitor 30<br />
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**[[2cjo]] – hKIF13+inhibitor 30<br />
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[[2nr8]] – hKIF9+ADP<br />
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**[[2nr8]] – hKIF9+ADP<br />
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[[2h58]] – hKIFC3+ADP<br />
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**[[2h58]] – hKIFC3+ADP<br />
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[[2gry]] – hKIF2+ADP<br />
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**[[2gry]] – hKIF2+ADP<br />
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[[2hfx]] – pKIF1A head+AMPPNP – pig<br />
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**[[2hfx]] – pKIF1A head+AMPPNP – pig<br />
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[[2hxh]] - pKIF1A head+ADP<br />
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**[[2hxh]] - pKIF1A head+ADP<br />
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''Kinesin heavy chain complex with protein''
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*''Kinesin heavy chain complex with protein''
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[[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br />
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**[[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br />
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[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br />
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**[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br />
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[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br />
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**[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br />
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[[4hna]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
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**[[4hna]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
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[[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br />
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**[[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br />
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[[1mkj]] – hKIF MD+docked FNL<br />
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**[[1mkj]] – hKIF MD+docked FNL<br />
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[[1n6m]] – DmKIF MD+FNL<br />
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**[[1n6m]] – DmKIF MD+FNL<br />
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[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – EM
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**[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – EM
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===Kinesin light chain (KLC)===
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*Kinesin light chain (KLC)
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[[3edt]] – hKLC2<br />
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**[[3edt]] – hKLC2<br />
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[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
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**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
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[[3zfw]] - mKLC2 TPR domain + peptide<br />
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**[[3zfw]] - mKLC2 TPR domain + peptide<br />
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===Kinesin-5 motor domain===
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*Kinesin-5 motor domain
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[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
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**[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
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[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
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**[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
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[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
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**[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
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[[4bxn]] - hKIF11+inhibitor +ADP + Cd<br />
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**[[4bxn]] - hKIF11+inhibitor +ADP + Cd<br />
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[[3l9h]] - hKIF11+inhibitor +ADP <br />
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**[[3l9h]] - hKIF11+inhibitor +ADP <br />
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[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
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**[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
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[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
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**[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
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[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
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**[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
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[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
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**[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
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[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
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**[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
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[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
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**[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
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[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
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**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
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===Kinesin-14===
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*Kinesin-14
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[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br />
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**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br />
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[[3l1c]] – DmNCD (mutant)
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**[[3l1c]] – DmNCD (mutant)
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===KCBP===
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*KCBP
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[[3h4s]] – KCBP+ADP+Mg – ''Arabidopsis thaliana''<br />
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**[[3h4s]] – KCBP+ADP+Mg – ''Arabidopsis thaliana''<br />
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===NOD===
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*NOD
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[[3dc4]] – DmNOD catalytic core domain+ADP<br />
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[[3dcb]] - DmNOD catalytic core domain+AMPPNP<br />
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[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
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**[[3dc4]] – DmNOD catalytic core domain+ADP<br />
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**[[3dcb]] - DmNOD catalytic core domain+AMPPNP<br />
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**[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:38, 30 November 2014

Template:STRUCTURE 2zfi

3D Structure of Kinesin
The image is a Crystal Structure of the Kif1A Motor Domain Before Mg Release (2zfi)

Kinesin

Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called Kar3. Eg5 or KIF11 is a kinesin (Kinesin-5) which participates in mitosis. KCBP is a Kinesin-like Calmodulin Binding Protein. NOD is a Drosophila chromosome-associated kinesin.

3D Structures of Kinesin

Updated on 30-November-2014

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