Pantothenate synthetase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PS===
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*'''Pantothenate synthetase'''
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[[1iho]] – EcPS – ''Escherichia coli''<br />
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**[[1iho]] – EcPS – ''Escherichia coli''<br />
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[[1mop]], [[2a88]], [[3cov]] – MtPS (mutant) – ''Mycobacterium tuberculosis''<br />
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**[[1mop]], [[2a88]], [[3cov]] – MtPS (mutant) – ''Mycobacterium tuberculosis''<br />
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[[1ufv]] - TtPS (mutant) – ''Thermus thermophilus''<br />
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**[[1ufv]] - TtPS (mutant) – ''Thermus thermophilus''<br />
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[[1v8f]] - TtPS <br />
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**[[1v8f]] - TtPS <br />
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[[2ejc]] - PS – ''Thermotoga maritima''<br />
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**[[2ejc]] - PS – ''Thermotoga maritima''<br />
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[[3mue]] - PS – ''Salmonella typhimurium''<br />
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**[[3mue]] - PS – ''Salmonella typhimurium''<br />
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[[3mxt]] - CjPS – ''Campylobacter jejuni''<br />
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**[[3mxt]] - CjPS – ''Campylobacter jejuni''<br />
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[[3ag5]] - SaPS – ''Staphylococcus aureus''
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**[[3ag5]] - SaPS – ''Staphylococcus aureus''
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===PS binary complex with adenosine derivatives===
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*Pantothenate synthetase binary complex with adenosine derivatives
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[[1n2g]] - MtPS + AMPCPP <br />
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**[[1n2g]] - MtPS + AMPCPP <br />
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[[2a7x]] - MtPS (mutant) + AMP<br />
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**[[2a7x]] - MtPS (mutant) + AMP<br />
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[[3n8h]] - FtPS + AMP – ''Francisella tularensis''<br />
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**[[3n8h]] - FtPS + AMP – ''Francisella tularensis''<br />
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[[3q10]] - YpPS + AMP – ''Yersinia pestis''<br />
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**[[3q10]] - YpPS + AMP – ''Yersinia pestis''<br />
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[[3uk2]] - PS + AMP – ''Burkholderia thailandesis''<br />
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**[[3uk2]] - PS + AMP – ''Burkholderia thailandesis''<br />
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[[2a84]] - MtPS (mutant) + ATP<br />
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**[[2a84]] - MtPS (mutant) + ATP<br />
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[[2x3f]] - SaPS + ATP derivative<br />
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**[[2x3f]] - SaPS + ATP derivative<br />
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[[3inn]] - PS + ATP – ''Brucella melitensis''<br />
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**[[3inn]] - PS + ATP – ''Brucella melitensis''<br />
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[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative
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**[[3iob]], [[3ioc]], [[3iod]], [[3ioe]] - MtPS (mutant) + adenosine derivative
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===PS binary complex with pantoate derivatives===
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*Pantothenate synthetase binary complex with pantoate derivatives
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[[1n2i]] - MtPS (mutant) + pantoyl adenylate<br />
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**[[1n2i]] - MtPS (mutant) + pantoyl adenylate<br />
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[[1n2j]] - MtPS (mutant) + pantoate<br />
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**[[1n2j]] - MtPS (mutant) + pantoate<br />
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[[1n2o]] - MtPS (mutant) + β-alanine<br />
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**[[1n2o]] - MtPS (mutant) + β-alanine<br />
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[[3q12]] - YpPS + pantoate <br />
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**[[3q12]] - YpPS + pantoate <br />
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[[3ag6]] - SaPS + pantoyl adenylate<br />
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**[[3ag6]] - SaPS + pantoyl adenylate<br />
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[[3guz]] - EcPS (mutant) + pantoate
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**[[3guz]] - EcPS (mutant) + pantoate
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*Pantothenate synthetase binary complex with inhibitor
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===PS binary complex with inhibitor===
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**[[3cow]], [[3coy]], [[3coz]], [[3imc]], [[3ime]], [[3img]], [[3iub]], [[3iue]], [[3ivc]], [[3ivg]], [[3ivx]], [[3isj]], [[3le8]], [[4ddh]], [[4ddk]], [[4ddm]], [[4de5]], [[4ef6]], [[4efk]], [[4fzj]], [[4g5f]] - MtPS (mutant) + inhibitor
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[[3cow]], [[3coy]], [[3coz]], [[3imc]], [[3ime]], [[3img]], [[3iub]], [[3iue]], [[3ivc]], [[3ivg]], [[3ivx]], [[3isj]], [[3le8]], [[4ddh]], [[4ddk]], [[4ddm]], [[4de5]], [[4ef6]], [[4efk]], [[4fzj]], [[4g5f]] - MtPS (mutant) + inhibitor
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*Pantothenate synthetase ternary complex
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===PS ternary complex===
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[[2a86]] - MtPS (mutant) + β-alanine + AMP<br />
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[[4g5y]] - MtPS (mutant) + thiophene derivative + ATP<br />
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[[3uy4]] - CjPS + pantothenate + AMP<br />
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[[3qtt]] - FtPS + β-alanine + ATP derivative<br />
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[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP
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**[[2a86]] - MtPS (mutant) + β-alanine + AMP<br />
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**[[4g5y]] - MtPS (mutant) + thiophene derivative + ATP<br />
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**[[3uy4]] - CjPS + pantothenate + AMP<br />
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**[[3qtt]] - FtPS + β-alanine + ATP derivative<br />
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**[[1n2b]], [[1n2e]] – MtPS + pantoate + AMPCPP
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:46, 2 December 2014

Template:STRUCTURE 2a7x

Pantothenate synthetase (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate. Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target.

3D structures of pantothenate synthetase

Updated on 02-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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