Phosphoglycerate dehydrogenase

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==3D structures of phosphoglycerate dehydrogenase==
==3D structures of phosphoglycerate dehydrogenase==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===PDGH===
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*'''Phosphoglycerate dehydrogenase'''
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[[1ygy]], [[3dc2]] – MtPGDH – ''Mycobacterium tuberculosis''<br />
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**[[1ygy]], [[3dc2]] – MtPGDH – ''Mycobacterium tuberculosis''<br />
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[[3evt]] - PGDH – ''Lactobacillus plantarum''<br />
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**[[3evt]] - PGDH – ''Lactobacillus plantarum''<br />
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[[3gg9]] - PGDH – ''Ralstonia solanacearum''<br />
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**[[3gg9]] - PGDH – ''Ralstonia solanacearum''<br />
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[[3k5p]] - PGDH (mutant) – ''Brucella melitensis''
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**[[3k5p]] - PGDH (mutant) – ''Brucella melitensis''
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===PGDH binary complex===
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*Phosphoglycerate dehydrogenase binary complex
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[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br />
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**[[1sc6]], [[2p9c]], [[2p9e]], [[2p9g]] - EcPGDH (mutant) + NAD – ''Escherichia coli''<br />
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[[1yba]] - EcPGDH + NAD<br />
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**[[1yba]] - EcPGDH + NAD<br />
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[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br />
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**[[1wwk]] - PGDH + NAD – ''Pyrococcus horikoshii''<br />
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[[2g76]] - PGDH + NAD – human<br />
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**[[2g76]] - PGDH + NAD – human<br />
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[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br />
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**[[2ekl]] - PGDH + NAD – ''Sulfolobus tokodaii''<br />
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[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate
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**[[3ddn]] - MtPGDH + hydroxypyruvic acid phosphate
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===PGDH ternary complex===
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*Phosphoglycerate dehydrogenase ternary complex
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[[1psd]] - EcPGDH + serine + NAD <br />
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[[2pa3]] - EcPGDH (mutant) + serine + NAD
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**[[1psd]] - EcPGDH + serine + NAD <br />
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**[[2pa3]] - EcPGDH (mutant) + serine + NAD
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:55, 3 December 2014

Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76

Drag the structure with the mouse to rotate

Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

3D structures of phosphoglycerate dehydrogenase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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