Plasmepsin
From Proteopedia
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==3D structures of plasmepsin== | ==3D structures of plasmepsin== | ||
| - | Updated | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
===HAP=== | ===HAP=== | ||
| - | [[3fns]] – PfHAP - ''Plasmodium falciparum''<br /> | + | [[3fns]], [[3qvc]] – PfHAP - ''Plasmodium falciparum''<br /> |
| - | [[3fnt]] – PfHAP + | + | [[3fnt]] – PfHAP + pepstatin<br /> |
| - | [[3fnu]] – PfHAP + | + | [[3fnu]], [[3qvi]] – PfHAP + inhibitor<br /> |
===Plm I=== | ===Plm I=== | ||
Revision as of 08:56, 2 September 2014
Template:STRUCTURE 3fns Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive.
Contents |
3D structures of plasmepsin
Updated on 02-September-2014
HAP
3fns, 3qvc – PfHAP - Plasmodium falciparum
3fnt – PfHAP + pepstatin
3fnu, 3qvi – PfHAP + inhibitor
Plm I
3qrv – PfPlm I residues 117-457
3qs1 - PfPlm I residues 117-457 + inhibitor
Plm II
1lf4 – PfPlm II
3f9q – PfPlm II (mutant)
2r9b – PfPlm II + peptide inhibitor
1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy – PfPlm II + inhibitor
1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative
1m43 - PfPlm II (mutant) + pepstatin derivative
ProPlm II
1pfz - PfProPlm II
1miq – PvProPlm II – Plasmodium vivax
1qs8 - PvPlm + pepstatin derivative
Plm IV
2anl – Plm IV + statine derivative – Plasmodium malariae
1ls5 - PfPlm IV + pepstatin derivative
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
