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Plasmepsin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===HAP===
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*Histo-Aspartic Protease
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[[3fns]], [[3qvc]] – PfHAP - ''Plasmodium falciparum''<br />
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**[[3fns]], [[3qvc]] – PfHAP - ''Plasmodium falciparum''<br />
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[[3fnt]] – PfHAP + pepstatin<br />
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**[[3fnt]] – PfHAP + pepstatin<br />
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[[3fnu]], [[3qvi]] – PfHAP + inhibitor<br />
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**[[3fnu]], [[3qvi]] – PfHAP + inhibitor<br />
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===Plm I===
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*Plasmepsin I
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[[3qrv]] – PfPlm I residues 117-457<br />
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**[[3qrv]] – PfPlm I residues 117-457<br />
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[[3qs1]] - PfPlm I residues 117-457 + inhibitor
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**[[3qs1]] - PfPlm I residues 117-457 + inhibitor
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===Plm II===
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*Plasmepsin II
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[[1lf4]] – PfPlm II<br />
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**[[1lf4]] – PfPlm II<br />
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[[3f9q]] – PfPlm II (mutant)<br />
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**[[3f9q]] – PfPlm II (mutant)<br />
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[[2r9b]] – PfPlm II + peptide inhibitor<br />
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**[[2r9b]] – PfPlm II + peptide inhibitor<br />
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[[1w6h]], [[2bju]], [[1lf2]], [[1lf3]], [[1lee]], [[2igx]], [[2igy]] – PfPlm II + inhibitor<br />
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**[[1w6h]], [[2bju]], [[1lf2]], [[1lf3]], [[1lee]], [[2igx]], [[2igy]] – PfPlm II + inhibitor<br />
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[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br />
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**[[1w6i]], [[1xdh]], [[1xe5]], [[1xe6]], [[1me6]], [[1sme]] – PfPlm II + pepstatin derivative<br />
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[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br />
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**[[1m43]] - PfPlm II (mutant) + pepstatin derivative<br />
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===ProPlm II===
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*Proplasmepsin II
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[[1pfz]] - PfProPlm II<br />
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**[[1pfz]] - PfProPlm II<br />
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[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br />
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**[[1miq]] – PvProPlm II – ''Plasmodium vivax''<br />
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[[1qs8]] - PvPlm + pepstatin derivative<br />
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**[[1qs8]] - PvPlm + pepstatin derivative<br />
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===Plm IV===
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*Plasmepsin IV
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[[2anl]] – Plm IV + statine derivative – ''Plasmodium malariae''<br />
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[[1ls5]] - PfPlm IV + pepstatin derivative<br />
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**[[2anl]] – Plm IV + statine derivative – ''Plasmodium malariae''<br />
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**[[1ls5]] - PfPlm IV + pepstatin derivative<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:23, 3 December 2014

Template:STRUCTURE 3fns Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive.


3D structures of plasmepsin

Updated on 03-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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