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4r3q

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'''Unreleased structure'''
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==Crystal structure of SYCE3==
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<StructureSection load='4r3q' size='340' side='right' caption='[[4r3q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r3q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R3Q FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r3q RCSB], [http://www.ebi.ac.uk/pdbsum/4r3q PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements.
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The entry 4r3q is ON HOLD
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Structural insight into the central element assembly of the synaptonemal complex.,Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919<ref>PMID:25394919</ref>
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Authors: Lu, J., Feng, J., Zhou, W., Yang, X., Shen, Y.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Crystal structure of SYCE3
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Feng, J]]
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[[Category: Lu, J]]
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[[Category: Shen, Y]]
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[[Category: Yang, X]]
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[[Category: Zhou, W]]
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[[Category: Cell cycle]]
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[[Category: Coiled-coil]]
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[[Category: Synaptonemal complex]]

Revision as of 07:59, 26 November 2014

Crystal structure of SYCE3

4r3q, resolution 1.90Å

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