1e5p
From Proteopedia
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|PDB= 1e5p |SIZE=350|CAPTION= <scene name='initialview01'>1e5p</scene>, resolution 1.63Å | |PDB= 1e5p |SIZE=350|CAPTION= <scene name='initialview01'>1e5p</scene>, resolution 1.63Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MESOCRICETUS AURATUS APHRODISIN GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Mesocricetus auratus]) | |GENE= MESOCRICETUS AURATUS APHRODISIN GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Mesocricetus auratus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e5p OCA], [http://www.ebi.ac.uk/pdbsum/1e5p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e5p RCSB]</span> | ||
}} | }} | ||
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[[Category: pheromone]] | [[Category: pheromone]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:55:41 2008'' |
Revision as of 16:55, 30 March 2008
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| , resolution 1.63Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | MESOCRICETUS AURATUS APHRODISIN GENE (Mesocricetus auratus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF APHRODISIN, A SEX PHEROMONE FROM FEMALE HAMSTER
Overview
We have solved the crystal structure of aphrodisin, a pheromonal protein inducing a copulatory behaviour in male hamster, using MAD methods with selenium, at 1.63 A resolution. The monomeric protein belongs to the lipocalin family, and possesses a disulfide bridge in a loop between strands 2 and 3. This disulfide bridge is characteristic of a family of lipocalins mainly identified in rodents, and is analogous to the fifth disulfide bridge of the long neurotoxins, such as alpha cobratoxin. An elongated electron density was found inside the buried cavity, which might represent a serendipitous ligand of unknown origin. The analysis of the water accessible surfaces of the side-chains bordering the cavity indicates that Phe76 may be the door for the natural ligand to access the cavity. This residue defines the entry of the cavity as belonging to the consensus for lipocalins. The face bearing Phe76 might also serve for the interaction with the receptor.
About this Structure
1E5P is a Single protein structure of sequence from Mesocricetus auratus. Full crystallographic information is available from OCA.
Reference
Crystal structure of aphrodisin, a sex pheromone from female hamster., Vincent F, Lobel D, Brown K, Spinelli S, Grote P, Breer H, Cambillau C, Tegoni M, J Mol Biol. 2001 Jan 19;305(3):459-69. PMID:11152604
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