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User:Avinash S. Punekar/Sandbox 1

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=== Overall structure ===
=== Overall structure ===
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The E. coli RlmJ structure consists of a <scene name='59/598869/Rlmj_helical_subdomain/1'>helical subdomain</scene> (HS, residues 47-98) inserted within the main <scene name='59/598869/Rlmj_mtase_domain/1'>methyltransferase domain</scene> (MTase, residues 1-46 and 99-280).
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The E. coli RlmJ structure consists of a <scene name='59/598869/Rlmj_helical_subdomain/1'>helical subdomain</scene> (HS, residues 47-98, colour: orange) inserted within the main <scene name='59/598869/Rlmj_mtase_domain/1'>methyltransferase domain</scene> (MTase, residues 1-46 and 99-280, colour: blue).

Revision as of 16:06, 7 September 2014

Introduction

Post-transcriptional modification of ribosomal RNA (rRNA) occurs in all living organisms. In bacteria, rRNA modifications are done by site-specific enzymes. One such rRNA modification enzyme is a S-adenosyl-L-methionine (SAM) dependent methyltransferase RlmJ. The biochemical experiments showed that the Escherichia coli RlmJ transfers a methyl group from SAM to the exocyclic nitrogen N6 of adenosine A2030 (m6A2030) in the 23S rRNA.

Methyltransferase RlmJ

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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Avinash S. Punekar

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