1e96

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|PDB= 1e96 |SIZE=350|CAPTION= <scene name='initialview01'>1e96</scene>, resolution 2.4&Aring;
|PDB= 1e96 |SIZE=350|CAPTION= <scene name='initialview01'>1e96</scene>, resolution 2.4&Aring;
|SITE= <scene name='pdbsite=GTP:Gtp+Binding+Site+For+Chain+A+Residue+200'>GTP</scene>
|SITE= <scene name='pdbsite=GTP:Gtp+Binding+Site+For+Chain+A+Residue+200'>GTP</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: tpr motif]]
[[Category: tpr motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:51:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:37:28 2008''

Revision as of 09:37, 23 March 2008

Image:1e96.jpg


PDB ID 1e96

Drag the structure with the mouse to rotate
, resolution 2.4Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE RAC/P67PHOX COMPLEX


Contents

Overview

p67phox is an essential part of the NADPH oxidase, a multiprotein enzyme complex that produces superoxide ions in response to microbial infection. Binding of the small GTPase Rac to p67phox is a key step in the assembly of the active enzyme complex. The structure of Rac.GTP bound to the N-terminal TPR (tetratricopeptide repeat) domain of p67phox reveals a novel mode of Rho family/effector interaction and explains the basis of GTPase specificity. Complex formation is largely mediated by an insertion between two TPR motifs, suggesting an unsuspected versatility of TPR domains in target recognition and in their more general role as scaffolds for the assembly of multiprotein complexes.

Disease

Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[608515]

About this Structure

1E96 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the TPR domain of p67phox in complex with Rac.GTP., Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K, Mol Cell. 2000 Oct;6(4):899-907. PMID:11090627

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