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4c3z
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C3Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C3Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c3z RCSB], [http://www.ebi.ac.uk/pdbsum/4c3z PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c3z RCSB], [http://www.ebi.ac.uk/pdbsum/4c3z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MRP1_HUMAN MRP1_HUMAN]] Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.<ref>PMID:10064732</ref> <ref>PMID:11114332</ref> <ref>PMID:16230346</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: BaubichonCortay, H | + | [[Category: BaubichonCortay, H]] |
| - | [[Category: Chaptal, V | + | [[Category: Chaptal, V]] |
| - | [[Category: DiPietro, A | + | [[Category: DiPietro, A]] |
| - | [[Category: Falson, P | + | [[Category: Falson, P]] |
| - | [[Category: GueguenChaignon, V | + | [[Category: GueguenChaignon, V]] |
| - | [[Category: Magnard, S | + | [[Category: Magnard, S]] |
[[Category: Atp-binding cassette transporter]] | [[Category: Atp-binding cassette transporter]] | ||
[[Category: General-base mechanism]] | [[Category: General-base mechanism]] | ||
[[Category: Multidrug resistance protein 1]] | [[Category: Multidrug resistance protein 1]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 07:20, 24 December 2014
Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.
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