Proto-oncogene serine/threonine-protein kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Pim1===
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*Pim1
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[[1xqz]], [[1ywv]] – hPim1 – human <br />
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**[[1xqz]], [[1ywv]] – hPim1 – human <br />
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[[1yxs]] – hPim1 (mutant) <br />
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**[[1yxs]] – hPim1 (mutant) <br />
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[[1xr1]], [[1yxt]] – hPim1 + AMPPNP <br />
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**[[1xr1]], [[1yxt]] – hPim1 + AMPPNP <br />
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[[1yxu]] – hPim1 + AMP <br />
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**[[1yxu]] – hPim1 + AMP <br />
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[[1yxv]], [[3uix]] – hPim1 + quinoline derivative <br />
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**[[1yxv]], [[3uix]] – hPim1 + quinoline derivative <br />
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[[1yxx]] – hPim1 + indole derivative <br />
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**[[1yxx]] – hPim1 + indole derivative <br />
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[[3a99]] – hPim1 + phosphoaminophosphonic acid adenylate <br />
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**[[3a99]] – hPim1 + phosphoaminophosphonic acid adenylate <br />
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[[2bzj]], [[2bzh]], [[2bzi]], [[2oi4]], [[3bwf]] – hPim1 (mutant) + organometallic ligand <br />
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**[[2bzj]], [[2bzh]], [[2bzi]], [[2oi4]], [[3bwf]] – hPim1 (mutant) + organometallic ligand <br />
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[[1xws]], [[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[4dtk]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[4ll5]], [[4lm5]] – hPim1 + inhibitor <br />
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**[[1xws]], [[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[4dtk]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[4ll5]], [[4lm5]] – hPim1 + inhibitor <br />
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[[2j2i]] – hPim1 (mutant)+ inhibitor <br />
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**[[2j2i]] – hPim1 (mutant)+ inhibitor <br />
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===Pim1 complex with consensus peptide===
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*Pim1 complex with consensus peptide
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[[2c3i]], [[4gw8]] – hPim1 (mutant) + inhibitor + consensus peptide <br />
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**[[2c3i]], [[4gw8]] – hPim1 (mutant) + inhibitor + consensus peptide <br />
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[[2bzk]] – hPim1 (mutant)+ AMPPNP + consensus peptide <br />
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**[[2bzk]] – hPim1 (mutant)+ AMPPNP + consensus peptide <br />
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[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[3jpv]], [[3qf9]] – hPim1 + inhibitor + consensus peptide<br />
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**[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[3jpv]], [[3qf9]] – hPim1 + inhibitor + consensus peptide<br />
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[[3ma3]] – hPim1 + inhibitor + PSer + consensus peptide<br />
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**[[3ma3]] – hPim1 + inhibitor + PSer + consensus peptide<br />
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===Pim1 containing phosphorylated Ser 261===
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*Pim1 containing phosphorylated Ser 261
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[[1yhs]] – hPim1 + PSer + staurosporine <br />
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**[[1yhs]] – hPim1 + PSer + staurosporine <br />
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[[1yi3]], [[2bik]], [[2obj]], [[3bgp]], [[3bgq]], [[3bgz]], [[3dcv]], [[3f2a]], [[2xix]], [[2xiy]], [[2xiz]], [[2xj0]], [[2xj1]], [[2xj2]], [[3t9i]], [[4a7c]] – hPim1 + PSer + inhibitor <br />
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**[[1yi3]], [[2bik]], [[2obj]], [[3bgp]], [[3bgq]], [[3bgz]], [[3dcv]], [[3f2a]], [[2xix]], [[2xiy]], [[2xiz]], [[2xj0]], [[2xj1]], [[2xj2]], [[3t9i]], [[4a7c]] – hPim1 + PSer + inhibitor <br />
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[[1yi4]] – hPim1 + PSer + adenosine <br />
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**[[1yi4]] – hPim1 + PSer + adenosine <br />
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===Pim1 raf===
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See [[Serine/threonine protein kinase]]
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*Pim1 raf see [[Serine/threonine protein kinase]]
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:30, 4 December 2014

Template:STRUCTURE 3cy2

Proto-oncogene serine/threonine-protein kinase (Pim1) is implicated with a variety of cancers. Pim1 is involved in cell cycle progression, apoptosis, transcriptional activation and signaling pathways. Pim1 phosphorylates and inhibits proapoptotic proteins. Pim1 is phosphorylated on serine 261 (PSer). The consensus peptide (pimtide) ARKRRRHPSGPPTA binds strongly to Pim1.

3D Structures of pim-1

Updated on 04-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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