S-adenosylhomocysteine hydrolase

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'''S-adenosylhomocysteine hydrolase''' (AHCH) converts S-adenosylhomocysteine (AdoHcy) to L-homocysteine and adenosine. AHCH uses NAD+ as cofactor. AHCH is an essential enzyme in processes like transmethylation, trans-sulfuration and purine metabolism.
'''S-adenosylhomocysteine hydrolase''' (AHCH) converts S-adenosylhomocysteine (AdoHcy) to L-homocysteine and adenosine. AHCH uses NAD+ as cofactor. AHCH is an essential enzyme in processes like transmethylation, trans-sulfuration and purine metabolism.
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</StructureSection>
==3D structures of S-adenosylhomocysteine hydrolase==
==3D structures of S-adenosylhomocysteine hydrolase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1ky4]] – rAHCH + NAD - rat<BR />
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*S-adenosylhomocysteine hydrolase
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[[1ky5]] – rAHCH (mutant) + NAD <BR />
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[[1b3r]] – rAHCH catalytic domain + NAD <BR />
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[[1a7a]] – hAHCH + NAD – human<BR />
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[[3d64]] – BpAHCH + NAD – ''Burkholderia pseudmallei''<BR />
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===AHCH complex with adenosine derivatives===
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**[[1ky4]] – rAHCH + NAD - rat<BR />
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**[[1ky5]] – rAHCH (mutant) + NAD <BR />
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**[[1b3r]] – rAHCH catalytic domain + NAD <BR />
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**[[1a7a]] – hAHCH + NAD – human<BR />
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**[[3d64]] – BpAHCH + NAD – ''Burkholderia pseudmallei''<BR />
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[[1d4f]], [[1xwf]] – rAHCH (mutant) + NAD + adenosine<BR />
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*S-adenosylhomocysteine hydrolase complex with adenosine derivatives
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[[1k0u]], [[2h5l]] – rAHCH + NAD + adenosine analog<BR />
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[[1li4]], [[3nj4]] – hAHCH + NAD + adenosine derivative<BR />
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**[[1d4f]], [[1xwf]] – rAHCH (mutant) + NAD + adenosine<BR />
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[[1v8b]] – AHCH + NAD + adenosine – ''Plasmodium falciparum''<BR />
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**[[1k0u]], [[2h5l]] – rAHCH + NAD + adenosine analog<BR />
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[[3dhy]], [[2ziz]], [[2zj0]], [[2zj1]] – MtAHCH + NAD + adenosine derivative – ''Mycobacterium tuberculosis''<BR />
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**[[1li4]], [[3nj4]] – hAHCH + NAD + adenosine derivative<BR />
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[[3ce6]] – MtAHCH + NAD + adenosine<BR />
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**[[1v8b]] – AHCH + NAD + adenosine – ''Plasmodium falciparum''<BR />
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[[3glq]] – BpAHCH + NAD + adenosine derivative <BR />
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**[[3dhy]], [[2ziz]], [[2zj0]], [[2zj1]] – MtAHCH + NAD + adenosine derivative – ''Mycobacterium tuberculosis''<BR />
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[[3n58]] – AHCH + NAD + adenosine – ''Brucella melitensis''<BR />
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**[[3ce6]] – MtAHCH + NAD + adenosine<BR />
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[[3ond]] – lAHCH + NAD + adenosine – lupin<BR />
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**[[3glq]] – BpAHCH + NAD + adenosine derivative <BR />
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[[3one]] – lAHCH + NAD + adenine <BR />
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**[[3n58]] – AHCH + NAD + adenosine – ''Brucella melitensis''<BR />
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[[3onf]] – lAHCH + NAD + adenosine derivative <BR />
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**[[3ond]] – lAHCH + NAD + adenosine – lupin<BR />
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**[[3one]] – lAHCH + NAD + adenine <BR />
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**[[3onf]] – lAHCH + NAD + adenosine derivative <BR />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:02, 9 December 2014

Structure of S-adenosylhomocysteine hydrolase dimer complex with NAD (PDB entry 3d64)

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3D structures of S-adenosylhomocysteine hydrolase

Updated on 09-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Karsten Theis, Joel L. Sussman

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