Subtilisin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== Native mature subtilisin ===
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* Native mature subtilisin
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[[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br />
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**[[2z2x]] – TkSub - ''Thermococcus kodakarensis''<br />
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[[1sca]], [[1scb]], [[1sbc]], [[3unx]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br />
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**[[1sca]], [[1scb]], [[1sbc]], [[3unx]] – BsSub - ''Bacillus subtilis'' (Subtilisin Carlsberg)<br />
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[[1pxq]] – BsSub - NMR<br />
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**[[1pxq]] – BsSub - NMR<br />
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[[1gns]], [[1sup]], [[1st2]], [[1s01]], [[1sbt]], [[2sbt]], [[2st1]] – BaSub - ''Bacillus amyloliquefaciens''<br />
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**[[1gns]], [[1sup]], [[1st2]], [[1s01]], [[1sbt]], [[2sbt]], [[2st1]] – BaSub - ''Bacillus amyloliquefaciens''<br />
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[[1iav]], [[1gci]], [[1jea]], [[1st3]] – BlSub - ''Bacillus lentus'' (Subtilisin Savinase)<br />
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**[[1iav]], [[1gci]], [[1jea]], [[1st3]] – BlSub - ''Bacillus lentus'' (Subtilisin Savinase)<br />
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[[1ea7]], [[3d43]], [[2ixt]] – spehricase – Sub from ''Bacillus sphaericus''<br />
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**[[1ea7]], [[3d43]], [[2ixt]] – spehricase – Sub from ''Bacillus sphaericus''<br />
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[[2gko]] – Sub – psychrophilic ''Bacillus subtilis''
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**[[2gko]] – Sub – psychrophilic ''Bacillus subtilis''
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=== Mutant mature subtilisin ===
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* Mutant mature subtilisin
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[[3f49]], [[3co0]], [[2zrq]], [[3vhq]] – TkSub (mutant) <br />
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**[[3f49]], [[3co0]], [[2zrq]], [[3vhq]] – TkSub (mutant) <br />
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[[1gnv]], [[1dui]], [[1sue]], [[1a2q]], [[1aqn]], [[1sua]], [[1au9]], [[1ak9]], [[1yja]], [[1yjb]], [[1yjc]], [[1sbh]], [[1sbi]], [[1sub]], [[1suc]], [[1sud]], [[1s02]] – BaSub (mutant)<br />
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**[[1gnv]], [[1dui]], [[1sue]], [[1a2q]], [[1aqn]], [[1sua]], [[1au9]], [[1ak9]], [[1yja]], [[1yjb]], [[1yjc]], [[1sbh]], [[1sbi]], [[1sub]], [[1suc]], [[1sud]], [[1s02]] – BaSub (mutant)<br />
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[[1ndu]], [[1q5p]], [[1c9j]], [[1c9m]], [[1c9n]] – BlSub (mutant)<br />
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**[[1ndu]], [[1q5p]], [[1c9j]], [[1c9m]], [[1c9n]] – BlSub (mutant)<br />
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[[2xrm]] - BcSub residues 19-321 - ''Bacillus clausii''<br />
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**[[2xrm]] - BcSub residues 19-321 - ''Bacillus clausii''<br />
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=== Unautoprocessed subtilisin (pro-Sub) ===
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* Unautoprocessed subtilisin (pro-Sub)
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[[2z2z]], [[2e1p]] – pro-TkSub <br />
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**[[2z2z]], [[2e1p]] – pro-TkSub <br />
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[[2zwo]], [[2zwp]], [[4jp8]] – pro-TKSub (mutant)<br />
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**[[2zwo]], [[2zwp]], [[4jp8]] – pro-TKSub (mutant)<br />
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[[2wv7]] – pro-BcSub <br />
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**[[2wv7]] – pro-BcSub <br />
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[[2wwt]], [[2x8j]] - pro-BcSub (mutant)<br />
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**[[2wwt]], [[2x8j]] - pro-BcSub (mutant)<br />
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[[3whi]] - pro-BcSub (mutant)<br />
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**[[3whi]] - pro-BcSub (mutant)<br />
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=== Mutant unautoprocessed subtilisin ===
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* Mutant unautoprocessed subtilisin
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[[2zwo]], [[2zwp]] – pro-TKSub
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**[[2zwo]], [[2zwp]] – pro-TKSub
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=== Mature subtilisin complexed with its propeptide ===
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* Mature subtilisin complexed with its propeptide
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[[3cnq]] – BaSub<br />
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**[[3cnq]] – BaSub<br />
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[[1spb]] – BaSub (mutant)<br />
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**[[1spb]] – BaSub (mutant)<br />
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[[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub<br />
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**[[3a3n]], [[3a3o]], [[3a3p]], [[2z56]], [[2z57]], [[2z58]], [[2z2y]], [[2z30]] – TkSub<br />
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[[3vv2]] – TkSub (mutant)<br />
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**[[3vv2]] – TkSub (mutant)<br />
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[[1scj]] – BsSub
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**[[1scj]] – BsSub
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=== Subtilisin complexed with polypeptide inhibitor ===
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* Subtilisin complexed with polypeptide inhibitor
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[[1y1k]], [[1y33]], [[1y34]], [[1y3b]], [[1y3c]], [[1y3d]], [[1y3f]], [[1y48]], [[1y4a]], [[1y4d]], [[1tm3]], [[1tm4]],
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**[[1y1k]], [[1y33]], [[1y34]], [[1y3b]], [[1y3c]], [[1y3d]], [[1y3f]], [[1y48]], [[1y4a]], [[1y4d]], [[1tm3]], [[1tm4]],
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[[1tm1]], [[1lw6]] – BaSub+ chymotripsin inhibitor 2<br />
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**[[1tm1]], [[1lw6]] – BaSub+ chymotripsin inhibitor 2<br />
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[[1tm5]], [[1tm7]], [[1tmg]], [[1to1]], [[1to2]] - BaSub+ chymotrypsin inhibitor 2 (mutant)<br />
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**[[1tm5]], [[1tm7]], [[1tmg]], [[1to1]], [[1to2]] - BaSub+ chymotrypsin inhibitor 2 (mutant)<br />
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[[3sic]], [[5sic]], [[2sic]] – BaSub+Streptomyces inhibitor SSI<br />
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**[[3sic]], [[5sic]], [[2sic]] – BaSub+Streptomyces inhibitor SSI<br />
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[[1yu6]] – BsSub+ovomucoid <br />
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**[[1yu6]] – BsSub+ovomucoid <br />
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[[1v5i]] – BaSubb+POIA1 peptide <br />
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**[[1v5i]] – BaSubb+POIA1 peptide <br />
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[[1tk2]], [[1ndq]] – BlSub+gramicidin S <br />
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**[[1tk2]], [[1ndq]] – BlSub+gramicidin S <br />
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[[1r0r]] – BsSub+ovomucoid<br />
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**[[1r0r]] – BsSub+ovomucoid<br />
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[[1oyv]] – BsSub+tomato inhibitor II<br />
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**[[1oyv]] – BsSub+tomato inhibitor II<br />
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[[1sbn]], [[1sib]], [[2sec]], [[1sni]], [[1cse]] – BsSub+Elgin C<br />
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**[[1sbn]], [[1sib]], [[2sec]], [[1sni]], [[1cse]] – BsSub+Elgin C<br />
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[[2sni]] - BaSub+Elgin C2 <br />
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**[[2sni]] - BaSub+Elgin C2 <br />
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[[1mee]] - BpSub+Elgin C – ''Bacillus pumilus''
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**[[1mee]] - BpSub+Elgin C – ''Bacillus pumilus''
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=== Subtilisin complexed with inhibitor ===
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* Subtilisin complexed with inhibitor
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[[3bgo]] – BaSub+azide <br />
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**[[3bgo]] – BaSub+azide <br />
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[[1c3l]] – BsSub+Xe<br />
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**[[1c3l]] – BsSub+Xe<br />
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[[1be8]] – BsSub+cinnamoyl<br />
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**[[1be8]] – BsSub+cinnamoyl<br />
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[[1be6]] - BsSub+cinnamoyl+acetonitrile<br />
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**[[1be6]] - BsSub+cinnamoyl+acetonitrile<br />
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[[1bfk]], [[1scd]] – BsSub+acetonitrile<br />
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**[[1bfk]], [[1scd]] – BsSub+acetonitrile<br />
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[[1bfu]], [[1af4]] – BsSub+dioxane<br />
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**[[1bfu]], [[1af4]] – BsSub+dioxane<br />
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[[1av7]], [[1avt]], [[3vsb]], [[1vsb]] – BsSub+boronic acid derivatives <br />
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**[[1av7]], [[1avt]], [[3vsb]], [[1vsb]] – BsSub+boronic acid derivatives <br />
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[[1scn]] – BsSub+carbamate derivative <br />
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**[[1scn]] – BsSub+carbamate derivative <br />
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[[1bh6]] – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – ''Bacillus licheniformis''<br />
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**[[1bh6]] – Sub DY+benzyloxycarbonyl-ala-pro-phe-chloromethyl ketone – ''Bacillus licheniformis''<br />
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[[2wuv]], [[2wuw]] – BlSub fragment+acetonitrile
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**[[2wuv]], [[2wuw]] – BlSub fragment+acetonitrile
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===Selenosubtilisin===
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*Selenosubtilisin
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[[1ubn]] – BaSel-Sub<br />
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**[[1ubn]] – BaSel-Sub<br />
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[[1sel]] – BsSel-Sub
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**[[1sel]] – BsSel-Sub
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===Savinase===
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*Savinase
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[[3bx1]], [[1svn]], [[4cfy]], [[4cfz]], [[4cg0]] – Sav – ''Bacillus lentus''
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**[[3bx1]], [[1svn]], [[4cfy]], [[4cfz]], [[4cg0]] – Sav – ''Bacillus lentus''
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:21, 10 December 2014

Template:STRUCTURE 2z2x

Subtilisin is a serine protease. It is widely used commercially in detergents. A 77 amino acid propeptide is cleaved from the N-terminus of pro-Sub to create the mature active enzyme. See detalis in User:Tommie Hata/Introduction to Protein Engineering-Subtilisin.

3D Structures of Subtilisin

Updated on 10-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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