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1izh
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZH FirstGlance]. <br> | <table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IZH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1izi|1izi]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1izi|1izi]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izh RCSB], [http://www.ebi.ac.uk/pdbsum/1izh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1izh RCSB], [http://www.ebi.ac.uk/pdbsum/1izh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
| - | [[Category: Hilgenfeld, R | + | [[Category: Hilgenfeld, R]] |
| - | [[Category: Klimkait, T | + | [[Category: Klimkait, T]] |
| - | [[Category: Konvalinka, J | + | [[Category: Konvalinka, J]] |
| - | [[Category: Kraeusslich, H G | + | [[Category: Kraeusslich, H G]] |
| - | [[Category: Lepsik, M | + | [[Category: Lepsik, M]] |
| - | [[Category: Machala, L | + | [[Category: Machala, L]] |
| - | [[Category: Mesters, J R | + | [[Category: Mesters, J R]] |
| - | [[Category: Mlcochova, P | + | [[Category: Mlcochova, P]] |
| - | [[Category: Prejdova, J | + | [[Category: Prejdova, J]] |
| - | [[Category: Skalicka, K | + | [[Category: Skalicka, K]] |
| - | [[Category: Soucek, M | + | [[Category: Soucek, M]] |
| - | [[Category: Sponarova, J | + | [[Category: Sponarova, J]] |
| - | [[Category: Stankova, M | + | [[Category: Stankova, M]] |
| - | [[Category: Strisovsky, K | + | [[Category: Strisovsky, K]] |
| - | [[Category: Svec, M | + | [[Category: Svec, M]] |
| - | [[Category: Uhlikova, T | + | [[Category: Uhlikova, T]] |
| - | [[Category: Vondrasek, J | + | [[Category: Vondrasek, J]] |
| - | [[Category: Weber, J | + | [[Category: Weber, J]] |
[[Category: Hiv-1 proteinase]] | [[Category: Hiv-1 proteinase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Potent inhibitor]] | [[Category: Potent inhibitor]] | ||
[[Category: Subsite binding]] | [[Category: Subsite binding]] | ||
Revision as of 12:26, 2 January 2015
Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
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Categories: HIV-1 retropepsin | Human immunodeficiency virus 1 | Hilgenfeld, R | Klimkait, T | Konvalinka, J | Kraeusslich, H G | Lepsik, M | Machala, L | Mesters, J R | Mlcochova, P | Prejdova, J | Skalicka, K | Soucek, M | Sponarova, J | Stankova, M | Strisovsky, K | Svec, M | Uhlikova, T | Vondrasek, J | Weber, J | Hiv-1 proteinase | Hydrolase | Potent inhibitor | Subsite binding
