1i16
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1i16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I16 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1i16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I16 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i16 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i16 RCSB], [http://www.ebi.ac.uk/pdbsum/1i16 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i16 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1i16 RCSB], [http://www.ebi.ac.uk/pdbsum/1i16 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL16_HUMAN IL16_HUMAN]] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ambrosius, D | + | [[Category: Ambrosius, D]] |
| - | [[Category: Baier, M | + | [[Category: Baier, M]] |
| - | [[Category: Ciosto, C | + | [[Category: Ciosto, C]] |
| - | [[Category: Georgescu, J | + | [[Category: Georgescu, J]] |
| - | [[Category: Holak, T A | + | [[Category: Holak, T A]] |
| - | [[Category: Kurth, R | + | [[Category: Kurth, R]] |
| - | [[Category: Lang, K | + | [[Category: Lang, K]] |
| - | [[Category: Lanzendoerfer, M | + | [[Category: Lanzendoerfer, M]] |
| - | [[Category: Muehlhahn, P | + | [[Category: Muehlhahn, P]] |
| - | [[Category: Renner, C | + | [[Category: Renner, C]] |
| - | [[Category: Zweckstetter, M | + | [[Category: Zweckstetter, M]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Lymphocyte chemoattractant factor]] | [[Category: Lymphocyte chemoattractant factor]] | ||
[[Category: Pdz domain]] | [[Category: Pdz domain]] | ||
Revision as of 07:11, 25 December 2014
STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES
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