1jjh
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jjh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JJH FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jjh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JJH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1by9|1by9]], [[2bop|2bop]], [[1f9f|1f9f]], [[1jj4|1jj4]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1by9|1by9]], [[2bop|2bop]], [[1f9f|1f9f]], [[1jj4|1jj4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10559 Bovine papillomavirus type 1])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10559 Bovine papillomavirus type 1])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jjh RCSB], [http://www.ebi.ac.uk/pdbsum/1jjh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jjh RCSB], [http://www.ebi.ac.uk/pdbsum/1jjh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bovine papillomavirus type 1]] | [[Category: Bovine papillomavirus type 1]] | ||
| - | [[Category: Hegde, R S | + | [[Category: Hegde, R S]] |
| - | [[Category: Kim, S S | + | [[Category: Kim, S S]] |
| - | [[Category: Schapira, M | + | [[Category: Schapira, M]] |
| - | [[Category: Wang, A F | + | [[Category: Wang, A F]] |
[[Category: Bpv-1]] | [[Category: Bpv-1]] | ||
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Dna-binding domain]] | [[Category: Dna-binding domain]] | ||
[[Category: E2]] | [[Category: E2]] | ||
Revision as of 03:38, 25 December 2014
E2 DNA-binding Domain from Bovine Papillomavirus Type 1
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