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Trypanothione reductase
From Proteopedia
(Difference between revisions)
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Trypanothione reductase | |
| - | [[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br /> | + | **[[2tpr]], [[1tyt]], [[1fea]], [[1feb]], [[1fec]] – CfTTR – ''Crithidia fasciculate''<br /> |
| - | [[1aog]], [[1nda]] – TcTTR – ''Trypanosoma cruzi''<br /> | + | **[[1aog]], [[1nda]] – TcTTR – ''Trypanosoma cruzi''<br /> |
| - | [[2jk6]] - LiTTR – ''Leishmania infantum''<br /> | + | **[[2jk6]] - LiTTR – ''Leishmania infantum''<br /> |
| - | [[2woi]] - TbTTR – ''Trypanosoma brucei'' | + | **[[2woi]] - TbTTR – ''Trypanosoma brucei'' |
| - | + | *Trypanothione reductase binary complex | |
| - | [[1bzl]] - TcTTR + TPT<BR /> | + | **[[1bzl]] - TcTTR + TPT<BR /> |
| - | [[1gxf]] - TcTTR + inhibitor<br /> | + | **[[1gxf]] - TcTTR + inhibitor<br /> |
| - | [[2wba]], [[2wov]] - TbTTR + NADPH <br /> | + | **[[2wba]], [[2wov]] - TbTTR + NADPH <br /> |
| - | [[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]] - TbTTR + inhibitor<br /> | + | **[[2wp5]], [[2wp6]], [[2wpc]], [[2wpe]], [[2wpf]], [[4nev]] - TbTTR + inhibitor<br /> |
| - | + | *Trypanothione reductase ternary complex | |
| - | [[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | + | **[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> |
| - | [[2yau]] - LiTTR + NADPH + inhibitor<br /> | + | **[[2yau]] - LiTTR + NADPH + inhibitor<br /> |
| - | [[2wow]] - TbTTR + NADPH + TPT<BR /> | + | **[[2wow]] - TbTTR + NADPH + TPT<BR /> |
| - | [[4adw]] - LiTTR + NADPH + TPT<br /> | + | **[[4adw]] - LiTTR + NADPH + TPT<br /> |
| - | [[4apn]] - LiTTR + NADPH + inhibitor<br | + | **[[4apn]] - LiTTR + NADPH + inhibitor<br /> |
| - | + | ||
| - | + | ||
| + | **[[1typ]] – CfTTR + NADP + TPT<BR /> | ||
| + | }} | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 12:06, 15 December 2014
Trypanothione reductase (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases caused by the parasites Trypanosoma and Leishmania.
3D structures of trypanothione reductase
Updated on 15-December-2014
