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Tryptophan synthase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===TrpS α subunit===
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*'''Tryptophan synthase α subunit'''
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[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
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**[[3vnd]] - TrpS α subunit – ''Shewanella frigidimarina''<br />
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[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br />
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**[[3tha]] - TrpS α subunit – ''Campylobacter jejuni''<br />
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[[3nav]] - TrpS α subunit – ''Vibrio cholerae''<br />
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**[[3nav]] - TrpS α subunit – ''Vibrio cholerae''<br />
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[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br />
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**[[1geq]] - PfTrpS α subunit - ''Pyrococcus furiosus''<br />
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[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br />
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**[[2dzp]], [[2dzs]], [[2dzt]], [[2dzu]], [[2dzv]], [[2dzw]], [[2dzx]], [[2e09]] - PfTrpS α subunit (mutant)<br />
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[[1rd5]] - TrpS α subunit – corn<br />
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**[[1rd5]] - TrpS α subunit – corn<br />
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[[1ujp]] - TtTrpS α subunit <br />
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**[[1ujp]] - TtTrpS α subunit <br />
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[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br />
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**[[1v7y]], [[1wq5]], [[1xc4]] - EcTrpS α subunit <br />
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[[1xcf]] - EcTrpS α subunit (mutant)<br />
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**[[1xcf]] - EcTrpS α subunit (mutant)<br />
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[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
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**[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br />
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''TrpS α binary complex''
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*Tryptophan synthase α binary complex
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[[1wxj]] - TtTrpS α subunit + indole propanol phosphate<br />
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**[[1wxj]] - TtTrpS α subunit + indole propanol phosphate<br />
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===TrpS β subunit===
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*'''Tryptophan synthase β subunit'''
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[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
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**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
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[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
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**[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
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[[2o2e]], [[2o2j]] - TrpS β subunit – ''Mycobacterium tuberculosis''<br />
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**[[2o2e]], [[2o2j]] - TrpS β subunit – ''Mycobacterium tuberculosis''<br />
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[[1v8z]] - PfTrpS β subunit <br />
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**[[1v8z]] - PfTrpS β subunit <br />
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[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
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**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
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''TrpS β binary complex''
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*Tryptophan synthase β binary complex
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[[2dh5]] - EcTrpS β subunit + PLP<br />
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**[[2dh5]] - EcTrpS β subunit + PLP<br />
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===TrpS α+β subunits===
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*'''Tryptophan synthase α+β subunits'''
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[[1wdw]] - PfTrpS α + β subunits <br />
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**[[1wdw]] - PfTrpS α + β subunits <br />
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''TrpS α+β binary complex''
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*Tryptophan synthase α+β binary complex
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[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
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**[[1ttp]], [[1ttq]], [[1bks]], [[2wsy]], [[1kfk]] - StTrpS α + β + PLP – ''Salmonella typhimurium''<br />
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[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
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**[[1a5a]], [[1k8x]] - StTrpS α (mutant) + β + PLP<br />
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[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br />
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**[[1k7x]], [[2j9z]] - StTrpS α + β (mutant) + PLP<br />
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[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br />
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**[[2tys]] - StTrpS α (mutant) + β (mutant) + Trp derivative<br />
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[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br />
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**[[1kfe]] - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate<br />
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[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br />
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**[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br />
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[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br />
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**[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br />
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[[3pr2]] - StTrpS α + β + inhibitor<br />
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**[[3pr2]] - StTrpS α + β + inhibitor<br />
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[[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - TrpS α + β + inhibitor – ''Salmonella enterica''<br />
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**[[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - TrpS α + β + inhibitor – ''Salmonella enterica''<br />
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''TrpS α+β ternary complex with PLP and inhibitor''
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*Tryptophan synthase α+β ternary complex with PLP and inhibitor
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[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]] - StTrpS α + β + inhibitor + PLP<br />
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**[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]] - StTrpS α + β + inhibitor + PLP<br />
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[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
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**[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br />
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''TrpS α+β ternary complex with PLP and IGP derivatives''
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*Tryptophan synthase α+β ternary complex with PLP and IGP derivatives
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[[1a5b]], [[1kfb]] - StTrpS α (mutant) + β + IGP + PLP<br />
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**[[1a5b]], [[1kfb]] - StTrpS α (mutant) + β + IGP + PLP<br />
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[[1k8z]] - StTrpS α + β (mutant) + IGP derivative + PLP<br />
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**[[1k8z]] - StTrpS α + β (mutant) + IGP derivative + PLP<br />
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[[1kfc]] - StTrpS α (mutant) + β + IGP derivative + PLP<br />
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**[[1kfc]] - StTrpS α (mutant) + β + IGP derivative + PLP<br />
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[[1k3u]], [[1k7e]], [[1k7f]] - StTrpS α + β + IGP derivative + PLP<br />
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**[[1k3u]], [[1k7e]], [[1k7f]] - StTrpS α + β + IGP derivative + PLP<br />
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[[1qoq]], [[2rh9]], [[2rhg]] - StTrpS α + β + IGP + PLP<br />
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**[[1qoq]], [[2rh9]], [[2rhg]] - StTrpS α + β + IGP + PLP<br />
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[[1qop]] - StTrpS α + β + IGP analog + PLP<br />
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**[[1qop]] - StTrpS α + β + IGP analog + PLP<br />
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[[2trs]], [[1beu]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
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**[[2trs]], [[1beu]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
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''TrpS α+β ternary complex with PLP and G3P derivatives''
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*Tryptophan synthase α+β ternary complex with PLP and G3P derivatives
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[[1wbj]] - StTrpS α + β + G3P + PLP<br />
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**[[1wbj]] - StTrpS α + β + G3P + PLP<br />
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[[2j9x]] - StTrpS α + β + G3P + acrylic acid derivative<br />
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**[[2j9x]] - StTrpS α + β + G3P + acrylic acid derivative<br />
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[[1k8y]] - StTrpS α + β (mutant) + G3P derivative + PLP<br />
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**[[1k8y]] - StTrpS α + β (mutant) + G3P derivative + PLP<br />
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[[1tjp]] - StTrpS α + β + G3P derivative + PLP<br />
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**[[1tjp]] - StTrpS α + β + G3P derivative + PLP<br />
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[[2tsy]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
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**[[2tsy]] - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
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[[1ubs]] - StTrpS α (mutant) + β (mutant) + serine + PLP<br />
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**[[1ubs]] - StTrpS α (mutant) + β (mutant) + serine + PLP<br />
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''TrpS α+β quaternary complex''
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*Tryptophan synthase α+β quaternary complex
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[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />
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[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
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**[[1a5s]] - StTrpS α + β + serine + inhibitor + PLP<br />
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**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:56, 15 December 2014

Template:STRUCTURE 1wbj

Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.

3D structures of tryptophan synthase

Updated on 15-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali

Retrieved from "http://52.214.119.220/wiki/index.php/Tryptophan_synthase"
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