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1hv2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HV2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HV2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hv2 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hv2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref> [[http://www.uniprot.org/uniprot/VHL_MOUSE VHL_MOUSE]] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Botuyan, M V | + | [[Category: Botuyan, M V]] |
| - | [[Category: Case, D A | + | [[Category: Case, D A]] |
| - | [[Category: Chazin, W J | + | [[Category: Chazin, W J]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Koth, C M | + | [[Category: Koth, C M]] |
| - | [[Category: Mer, G | + | [[Category: Mer, G]] |
| - | [[Category: Yi, G S | + | [[Category: Yi, G S]] |
[[Category: Protein-peptide complex]] | [[Category: Protein-peptide complex]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 16:53, 25 December 2014
SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE
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