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1kl8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kl8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus] and [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kl8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus] and [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KL8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1abt|1abt]], [[1idh|1idh]], [[2abx|2abx]], [[1i9b|1i9b]], [[1hc9|1hc9]], [[1jbd|1jbd]], [[1kc4|1kc4]], [[1kfh|1kfh]], [[1haj|1haj]], [[1bxp|1bxp]], [[1ikc|1ikc]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1abt|1abt]], [[1idh|1idh]], [[2abx|2abx]], [[1i9b|1i9b]], [[1hc9|1hc9]], [[1jbd|1jbd]], [[1kc4|1kc4]], [[1kfh|1kfh]], [[1haj|1haj]], [[1bxp|1bxp]], [[1ikc|1ikc]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kl8 RCSB], [http://www.ebi.ac.uk/pdbsum/1kl8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kl8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kl8 RCSB], [http://www.ebi.ac.uk/pdbsum/1kl8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXL1A_BUNMU NXL1A_BUNMU]] Binds with high affinity to muscular and neuronal (alpha-7, alpha-8, and alpha-9) nicotinic acetylcholine receptors. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM).<ref>PMID:9305882</ref> <ref>PMID:9840221</ref> [[http://www.uniprot.org/uniprot/ACHA7_CHICK ACHA7_CHICK]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bungarus multicinctus]] | [[Category: Bungarus multicinctus]] | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
| - | [[Category: Basus, V J | + | [[Category: Basus, V J]] |
| - | [[Category: Hawrot, E | + | [[Category: Hawrot, E]] |
| - | [[Category: Moise, L | + | [[Category: Moise, L]] |
| - | [[Category: Piserchio, A | + | [[Category: Piserchio, A]] |
[[Category: Alpha-bungarotoxin]] | [[Category: Alpha-bungarotoxin]] | ||
[[Category: Alpha-neurotoxin]] | [[Category: Alpha-neurotoxin]] | ||
Revision as of 13:29, 25 December 2014
NMR STRUCTURAL ANALYSIS OF THE COMPLEX FORMED BETWEEN ALPHA-BUNGAROTOXIN AND THE PRINCIPAL ALPHA-NEUROTOXIN BINDING SEQUENCE ON THE ALPHA7 SUBUNIT OF A NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
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